Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Manoj Chiney"'
Autor:
Bindu Murthy, Qihong Zhao, Takafumi Ide, Manoj Chiney, Huynh Yen Thanh Bach, Vineet Goti, Coburn Hobar, Urvi Aras
Publikováno v:
Lupus Science and Medicine, Vol 10, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/dd0bbd07c41a406194c485d98d89d279
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 1, Pp 395-404 (2021)
Clinical and Translational Science
Clinical and Translational Science
Antibody drug conjugates (ADCs) provide targeted delivery of cytotoxic agents directly inside tumor cells. However, many ADCs targeting solid tumors have exhibited limited clinical efficacy, in part, due to insufficient penetration within tumors. To
Autor:
Jianqing Li, Daniel Smith, John S. Tokarski, Lihong Cheng, John E. Macor, Javed Khan, Adriana Zupa-Fernandez, Anil Thankappan, Chunjian Liu, Charu Chaudhry, David S. Weinstein, Percy H. Carter, Kathleen M. Gillooly, Kim W. McIntyre, Yifan Zhang, Anjaneya Chimalakonda, Joann Strnad, James Lin, James R. Burke, David J. Shuster, Manoj Chiney, Paul A. Elzinga, Max Ruzanov, Louis J. Lombardo, Charles M. Langevine
Publikováno v:
Journal of Medicinal Chemistry. 64:677-694
A search for structurally diversified Tyk2 JH2 ligands from 6 (BMS-986165), a pyridazine carboxamide-derived Tyk2 JH2 ligand as a clinical Tyk2 inhibitor currently in late development for the treatment of psoriasis, began with a survey of six-membere
Publikováno v:
Clinical Pharmacokinetics
Introduction Elagolix is approved for the management of moderate-to-severe pain associated with endometriosis. The aim of this analysis was to develop a physiologically based pharmacokinetic (PBPK) model that describes the enzyme-transporter interpla
Autor:
Yanlei Zhang, Jeffrey Tredup, Mertzman Michael E, Nelly Aranibar, Kim W. McIntyre, Kathleen M. Gillooly, Jodi K. Muckelbauer, James R. Burke, Lihong Cheng, Joann Strnad, Celia D’Arienzo, Dawn Mulligan, Stephen T. Wrobleski, Charu Chaudhry, Adriana Zupa-Fernandez, Percy H. Carter, Dianlin Xie, Manoj Chiney, Elizabeth M. Heimrich, Moslin Ryan M, Christine Huang, Xiaoxia Yang, Shuqun Lin, David S. Weinstein, Tokarski John S, Chiehying Chang, Louis J. Lombardo, Huadong Sun, Steven H. Spergel
Publikováno v:
Journal of Medicinal Chemistry. 62:8953-8972
As a member of the Janus (JAK) family of nonreceptor tyrosine kinases, TYK2 plays an important role in mediating the signaling of pro-inflammatory cytokines including IL-12, IL-23, and type 1 interferons. The nicotinamide 4, identified by a SPA-based
Publikováno v:
Xenobiotica. 48:904-910
1. Venetoclax is a novel, small molecule B-cell lymphoma-2 (BCL-2) inhibitor that has demonstrated clinical efficacy in a variety of haematological malignancies. Since venetoclax is an inhibitor of P glycoprotein (P-gp) transporter, a study was condu
Autor:
Max Ruzanov, David J. Shuster, Manoj Chiney, Kim W. McIntyre, James R. Burke, Celia D’Arienzo, Nelly Aranibar, Elizabeth M. Heimrich, Louis J. Lombardo, Dianlin Xie, Moslin Ryan M, Joann Strnad, Anjaneya Chimalakonda, Lihong Cheng, James Kempson, Adriana Zupa-Fernandez, Javed Khan, Charu Chaudhry, Huadong Sun, Shuqun Lin, Percy H. Carter, Steven H. Spergel, Christine Huang, Dawn Mulligan, Stephen T. Wrobleski, Kathleen M. Gillooly, Yanlei Zhang, Jeffrey Tredup, David S. Weinstein, Tokarski John S, William J. Pitts, Xiaoxia Yang
Publikováno v:
Journal of medicinal chemistry. 62(20)
Small molecule JAK inhibitors have emerged as a major therapeutic advancement in treating autoimmune diseases. The discovery of isoform selective JAK inhibitors that traditionally target the catalytically active site of this kinase family has been a
Autor:
Ryan, Moslin, Yanlei, Zhang, Stephen T, Wrobleski, Shuqun, Lin, Michael, Mertzman, Steven, Spergel, John S, Tokarski, Joann, Strnad, Kathleen, Gillooly, Kim W, McIntyre, Adriana, Zupa-Fernandez, Lihong, Cheng, Huadong, Sun, Charu, Chaudhry, Christine, Huang, Celia, D'Arienzo, Elizabeth, Heimrich, Xiaoxia, Yang, Jodi K, Muckelbauer, ChiehYing, Chang, Jeffrey, Tredup, Dawn, Mulligan, Dianlin, Xie, Nelly, Aranibar, Manoj, Chiney, James R, Burke, Louis, Lombardo, Percy H, Carter, David S, Weinstein
Publikováno v:
Journal of medicinal chemistry. 62(20)
As a member of the Janus (JAK) family of nonreceptor tyrosine kinases, TYK2 plays an important role in mediating the signaling of pro-inflammatory cytokines including IL-12, IL-23, and type 1 interferons. The nicotinamide
Autor:
Y.-W. Chang, Victor Moreno, Mark J. Ratain, Emiliano Calvo, Patricia LoRusso, Monica Motwani, Sudhir Penugonda, M.J.A. de Jonge, Drew W. Rasco, Adam M. Petrich, Manoj Chiney
Publikováno v:
Annals of Oncology. 30:v169-v170
Background ABBV-621, a tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor agonist, induces cell death in tumor cells by activation of death receptor 4 and 5. Maximum tolerated dose was not reached in dose escalation (Ratain et a
Autor:
Mark J. Ratain, Emiliano Calvo, Martin Dunbar, Drew W. Rasco, Maja J.A. de Jonge, Adam M. Petrich, Patricia LoRusso, Manoj Chiney, Toshihiko Doi, Jaimee Glasgow, Monica Motwani
Publikováno v:
Journal of Clinical Oncology. 37:3013-3013
3013 Background: ABBV-621 is a potent tumor-necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor agonist fusion protein that induces apoptotic cell death, particularly in DR4/5 expressing tumor models. Methods: Patients (pts) with previ