Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Manoj Chandran"'
Benzothiazinone-piperazine derivatives as efficient Mycobacterium tuberculosis DNA gyrase inhibitors
Autor:
Manoj Chandran, Janupally Renuka, Jonnalagadda Padma Sridevi, Ganesh S Pedgaonkar, Vanaparthi Asmitha, Perumal Yogeeswari, Dharmarajan Sriram
Publikováno v:
International Journal of Mycobacteriology, Vol 4, Iss 2, Pp 104-115 (2015)
Background and objectives: Bacterial DNA topoisomerases are unique in maintaining the DNA topology for cell viability. Mycobacterium tuberculosis (MTB) DNA gyrase, a sole type II topoisomerase has a larger scope as a target for developing novel thera
Externí odkaz:
https://doaj.org/article/75ea5bd0e2334e23a8d2f38b31482be6
Autor:
R. Kaushal, Tarun Kumar, Avnindra Singh, J. M. S. Tomar, H. Mehta, Manoj Chandran, S. T. S. Lepcha, J. Durai
Publikováno v:
Current Science. 121:1238
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::748768f636c48732983dfed41411ed08
https://doi.org/10.18520/cs/v121/i9/1238-1240
https://doi.org/10.18520/cs/v121/i9/1238-1240
Benzothiazinone-piperazine derivatives as efficient Mycobacterium tuberculosis DNA gyrase inhibitors
Autor:
Ganesh S. Pedgaonkar, Perumal Yogeeswari, Dharmarajan Sriram, Janupally Renuka, Vanaparthi Asmitha, Jonnalagadda Padma Sridevi, Manoj Chandran
Publikováno v:
International Journal of Mycobacteriology, Vol 4, Iss 2, Pp 104-115 (2015)
Background and objectives Bacterial DNA topoisomerases are unique in maintaining the DNA topology for cell viability. Mycobacterium tuberculosis (MTB) DNA gyrase, a sole type II topoisomerase has a larger scope as a target for developing novel therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3676e826a2d95cf374e2de8900340f2d
Autor:
Yogeeswari Perumal, Brindha Devi Parthiban, Shailendra K. Saxena, Sriram Dharmarajan, Padma Sridevi Jonnalagadda, Rudraraju Reshma Srilakshmi, Manoj Chandran, Renu Yadav
Publikováno v:
Chemical biologydrug design. 87(2)
Lysine ɛ-aminotransferase (LAT) is a protein involved in lysine catabolism, and it plays a significant role during the persistent/latent phase of Mycobacterium tuberculosis (MTB), as observed by its up-regulation by ~40-fold during this stage. We ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f9ae5f4a484be5b4c77a487409f5a3
https://pubmed.ncbi.nlm.nih.gov/26348876
https://pubmed.ncbi.nlm.nih.gov/26348876
Autor:
Mallika Alvala, Pulla Venkat Koushik, Perumal Yogeeswari, Manoj Chandran, Variam Ullas Jeankumar, Ganesh Samala, Elena G. Salina, Dharmarajan Sriram
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(24)
Twenty eight 5-nitrothiazole derivatives were synthesized and evaluated for in vitro activities against Mycobacterium tuberculosis (MTB), cytotoxicity against HEK 293T. Among the compounds, 5-nitro-N-(5-nitrothiazol-2-yl)furan-2-carboxamide (20) was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f164a44e8b16aeb0ad3b4a3cb00277
https://pubmed.ncbi.nlm.nih.gov/23137434
https://pubmed.ncbi.nlm.nih.gov/23137434