Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Manoj Amrutkar"'
Autor:
Yuchuan Li, Manoj Amrutkar, Anette Vefferstad Finstadsveen, Knut Tomas Dalen, Caroline S. Verbeke, Ivar P. Gladhaug
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-20 (2023)
Abstract Background Despite therapeutic advances, the prognosis of pancreatic ductal adenocarcinoma (PDAC) remains extremely poor. Metabolic reprogramming is increasingly recognized as a key contributor to tumor progression and therapy resistance in
Externí odkaz:
https://doaj.org/article/74434962bd09482d846da247de4e9099
Autor:
Manoj Amrutkar, Kjersti Berg, Aina Balto, Miguel G. Skilbrei, Anette V. Finstadsveen, Monica Aasrum, Ivar P. Gladhaug, Caroline S. Verbeke
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-17 (2023)
Abstract Background Profound resistance to chemotherapy remains a major challenge in achieving better clinical outcomes for patients with pancreatic ductal adenocarcinoma (PDAC). Recent studies indicate that gemcitabine (GEM) resistance is promoted b
Externí odkaz:
https://doaj.org/article/0a8551fe28fd4ded98dac870dafde5e6
Autor:
Manoj Amrutkar, Caroline S. Verbeke, Anette Vefferstad Finstadsveen, Linda Dorg, Knut Jørgen Labori, Ivar P. Gladhaug
Publikováno v:
Molecular Oncology, Vol 17, Iss 1, Pp 59-81 (2023)
The modest clinical benefits of neoadjuvant chemotherapy (NAT) in pancreatic ductal adenocarcinoma (PDAC) are associated with a lack of robust data on treatment‐induced changes in the tumor. To this end, comparative proteomic profiling of tumor tis
Externí odkaz:
https://doaj.org/article/fe5b77bf594f407d93f1ecf9688ee52d
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-16 (2019)
Abstract Background Gemcitabine remains a cornerstone in chemotherapy of pancreatic ductal adenocarcinoma (PDAC) despite suboptimal clinical effects that are partly due to the development of chemoresistance. Pancreatic stellate cells (PSCs) of the tu
Externí odkaz:
https://doaj.org/article/c056b0f49e6d4e2ba4b1c4847316ec3b
Autor:
Emmelie Cansby, Esther Nuñez-Durán, Elin Magnusson, Manoj Amrutkar, Sheri L. Booten, Nagaraj M. Kulkarni, L. Thomas Svensson, Jan Borén, Hanns-Ulrich Marschall, Mariam Aghajan, Margit Mahlapuu
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 3, Pp 597-618 (2019)
Background & Aims: Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are emerging as leading causes of liver disease worldwide. Currently, no specific pharmacologic therapy is available for NAFLD/NASH, which has been re
Externí odkaz:
https://doaj.org/article/9be6ef8a91c74cad8b389b66aebc0dd6
Autor:
Manoj Amrutkar, Emma Kristine Larsen, Monica Aasrum, Anette Vefferstad Finstadsveen, Per Arne Andresen, Caroline S. Verbeke, Ivar P. Gladhaug
Publikováno v:
Cells, Vol 9, Iss 1, p 227 (2020)
Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extremely poor prognosis, and its treatment remains a challenge. As the existing in vitro experimental models offer only a limited resemblance to human PDAC, there is a strong need for ad
Externí odkaz:
https://doaj.org/article/e017ea439478445bb8d912819d80296a
Autor:
Daniela Lenggenhager, Manoj Amrutkar, Petra Sántha, Monica Aasrum, Johannes-Matthias Löhr, Ivar P. Gladhaug, Caroline S. Verbeke
Publikováno v:
Cells, Vol 8, Iss 1, p 23 (2019)
Activated pancreatic stellate cells (PSCs) play a central role in the tumor stroma of pancreatic ductal adenocarcinoma (PDAC). Given the limited availability of patient-derived PSCs from PDAC, immortalized PSC cell lines of murine and human origin ha
Externí odkaz:
https://doaj.org/article/77432b1f851149b38e86f50682b82d4f
Autor:
Carina Sihlbom, Marcus Ståhlman, Margit Mahlapuu, Annika Nerstedt, Emmelie Cansby, Jan Borén, Hanns-Ulrich Marschall, Nagaraj M. Kulkarni, Elin Magnusson, Yeshwant Kurhe, Manoj Amrutkar, Matthias Blüher
Publikováno v:
The FASEB Journal. 33:9974-9989
Ectopic lipid storage in the liver is considered the main risk factor for nonalcoholic steatohepatitis (NASH). Understanding the molecular networks controlling hepatocellular lipid deposition is therefore essential for developing new strategies to ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3c87591f464adbc20146d73c269e0d
https://doi.org/10.1096/fj.201900356rr
https://doi.org/10.1096/fj.201900356rr
Autor:
Margit Mahlapuu, Manoj Amrutkar, Emmelie Cansby, Mara Caputo, Sima Kumari, Eli Scandalis, Mariam Aghajan, Yeshwant Kurhe, Jan Borén, Hanns-Ulrich Marschall, Sheri L. Booten, Marcus Ståhlman
Publikováno v:
The FASEB Journal. 35
Nonalcoholic fatty liver disease (NAFLD) is emerging as a leading cause of chronic liver disease worldwide. Despite intensive nonclinical and clinical research in this field, no specific pharmacological therapy is currently approved to treat NAFLD, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca90371804919679a5879d4d8b4c22a1
https://doi.org/10.1096/fj.202002671rr
https://doi.org/10.1096/fj.202002671rr
Autor:
Linda T. Dorg, Ivar P. Gladhaug, Kristin Tøndel, Manoj Amrutkar, Petra Sántha, Daniela Lenggenhager, Caroline S. Verbeke, Anette Vefferstad Finstadsveen
Publikováno v:
Cancers, Vol 13, Iss 895, p 895 (2021)
Cancers
Volume 13
Issue 4
13:895
Cancers
Volume 13
Issue 4
13:895
Inter- and intratumor heterogeneity is an important cause of treatment failure. In human pancreatic cancer (PC), heterogeneity has been investigated almost exclusively at the genomic and transcriptional level. Morphological heterogeneity, though prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88833b0a34a8d2ff2b0f73843d5b4e59
https://pubmed.ncbi.nlm.nih.gov/33672734
https://pubmed.ncbi.nlm.nih.gov/33672734