Benefits and obstacles to cell therapy in neonates: The INCuBAToR (Innovative Neonatal Cellular Therapy for Bronchopulmonary Dysplasia: Accelerating Translation of Research)

Autor: Bernard Thébaud, Manoj Lalu, Laurent Renesme, Sasha vanKatwyk, Justin Presseau, Kednapa Thavorn, Kelly D. Cobey, Brian Hutton, David Moher, Roger F. Soll, Dean Fergusson

Publikováno v: Stem Cells Translational Medicine, Vol 10, Iss 7, Pp 968-975 (2021)

Abstract Cell‐based therapies hold promise to substantially curb complications from extreme preterm birth, the main cause of death in children below the age of 5 years. Exciting preclinical studies in experimental neonatal lung injury have provided

Externí odkaz: https://doaj.org/article/2791354e597442ad92ae5be3758ae715

Mesenchymal stromal cell‐derived extracellular vesicles for regenerative therapy and immune modulation: Progress and challenges toward clinical application

Autor: David Allan, Alvin Tieu, Manoj Lalu, Dylan Burger

Publikováno v: Stem Cells Translational Medicine, Vol 9, Iss 1, Pp 39-46 (2020)

Abstract Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) have emerged as a promising form of regenerative therapy and immune modulation. Fundamental advances in our understanding of MSCs and EVs have allowed these fields to

Externí odkaz: https://doaj.org/article/ccbf2ae44dc54b2d9b24bbf11980b87a

Defining predatory journals and responding to the threat they pose: a modified Delphi consensus process

Autor: Agnes Grudniewicz, Kelly D Cobey, Manoj Lalu, Samantha Cukier, Gregory L Bryson

Publikováno v: BMJ Open, Vol 10, Iss 2 (2020)

ObjectiveTo conduct a Delphi survey informing a consensus definition of predatory journals and publishers.DesignThis is a modified three-round Delphi survey delivered online for the first two rounds and in-person for the third round. Questions encomp

Externí odkaz: https://doaj.org/article/aefed735f059492e9764943febcabfd0

Systematic reviews and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: mortality, morbidity, and organ failure

Autor: Alexander I.R. Jackson, Oliver Boney, Rupert M. Pearse, Andrea Kurz, D. James Cooper, Wilton A. van Klei, Luca Cabrini, Timothy E. Miller, S. Ramani Moonesinghe, Paul S. Myles, Michael P.W. Grocott, Paul Myles, T.J. Gan, Phil Peyton, Dan Sessler, Martin Tramèr, Alan Cyna, Gildasio S. De Oliveira, Christopher Wu, Mark Jensen, Henrik Kehlet, Mari Botti, Guy Haller, Mike Grocott, Tim Cook, Lee Fleisher, Mark Neuman, David Story, Russell Gruen, Sam Bampoe, Lis Evered, David Scott, Brendan Silbert, Diederik van Dijk, Cor Kalkman, Matthew Chan, Hilary Grocott, Rod Eckenhoff, Lars Rasmussen, Lars Eriksson, Scott Beattie, Duminda Wijeysundera, Giovanni Landoni, Kate Leslie, Bruce Biccard, Simon Howell, Peter Nagele, Toby Richards, Andre Lamy, Manoj Lalu, Rupert Pearse, Monty Mythen, Jaume Canet, Ann Moller, Tony Gin, Marcus Schultz, Paolo Pelosi, Marcelo Gabreu, Emmanuel Futier, Ben Creagh-Brown, Tom Abbot, Andy Klein, Tomas Corcoran, D. Jamie Cooper, Stefan Dieleman, Elisabeth Diouf, David McIlroy, Rinaldo Bellomo, Andrew Shaw, John Prowle, Keyvan Karkouti, Josh Billings, David Mazer, Mohindas Jayarajah, Michael Murphy, Justyna Bartoszko, Rob Sneyd, Steve Morris, Ron George, Ramani Moonesinghe, Mark Shulman, Meghan Lane-Fall, Ulrica Nilsson, Nathalie Stevenson, Wilton van Klei, Tim Miller, Sandy Jackson, Donal Buggy, Tim Short, Bernhard Riedel, Vijay Gottumukkala, Nathan Pace, Bilal Alkhaffaf, Mark Johnson

Publikováno v: British journal of anaesthesia, 130(4), 404-411. Oxford University Press
The StEP-COMPACGroup 2023, ' Systematic reviews and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative : mortality, morbidity, and organ failure ', British Journal of Anaesthesia, vol. 130, no. 4, pp. 404-411 . https://doi.org/10.1016/j.bja.2022.12.012

Background: Mortality, morbidity, and organ failure are important and common serious harms after surgery. However, there are many candidate measures to describe these outcome domains. Definitions of these measures are highly variable, and validity is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c12cfbdacde370b1003dfde0dc401766
https://pure.amc.nl/en/publications/systematic-reviews-and-consensus-definitions-for-the-standardised-endpoints-in-perioperative-medicine-step-initiative(48cb1751-2f3f-47b7-b21a-1b40127c190b).html

A systematic assessment of preclinical multilaboratory studies and a comparison to single laboratory studies

Autor: Manoj Lalu

Publikováno v: eLife. 12

Background:Multicentric approaches are widely used in clinical trials to assess the generalizability of findings, however, they are novel in laboratory-based experimentation. It is unclear how multilaboratory studies may differ in conduct and results

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be6bdf6dd25d56c950ac15d6a0fe0727
https://doi.org/10.7554/elife.76300