Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Manoj, Bajpai"'
Autor:
Ann J. Barbier, Steven B Sands, Lilian Y Li, Anthony Ndifor, Chandra R. Shah, Kirsten L. Morton, Michael A. Letavic, Timothy W. Lovenberg, Anne Bonneville, Heather McAllister, Neelakandha S. Mani, Ian Fraser, Kiev S. Ly, Richard Apodaca, Nicholas I. Carruthers, Manoj Bajpai, Swanson Devin M, Michelle Kramer, Christine Dugovic, Sandra S Snook, Chennagiri R. Pandit, Jonathan Shelton, Wei Xiao, Leah Aluisio, Pascal Bonaventure, Brian Lord, S Diane Nepomuceno
Publikováno v:
ACS Medicinal Chemistry Letters. 6:450-454
The preclinical characterization of novel phenyl(piperazin-1-yl)methanones that are histamine H3 receptor antagonists is described. The compounds described are high affinity histamine H3 antagonists. Optimization of the physical properties of these h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb111c3b07b944a678c3abee290cc57f
https://doi.org/10.1021/ml5005156
https://doi.org/10.1021/ml5005156
Autor:
Bruce Y. Tung, Brian Phillips, Joel Esmay, Manoj Bajpai, Danny D. Shen, Adam E. Levy, Victor Chi, Rodney J. Y. Ho, Kenneth E. Thummel, Kris V. Kowdley, Miklos Bodor, Lisa A. McConnachie
Publikováno v:
Clinical Pharmacology & Therapeutics. 75:282-297
Objective The goal of this study was to develop and validate a cytochrome P450 (CYP) 2D6 probe substrate with improved sensitivity to elucidate the relationship of CYP2D6 ribonucleic acid transcript levels, genotype, and enzyme activity in human live
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::840517c6fa71b3dbdab1191793e01016
https://doi.org/10.1016/j.clpt.2003.12.003
https://doi.org/10.1016/j.clpt.2003.12.003
Publikováno v:
Drug Metabolism and Disposition. 31:1103-1107
Genotyping of the highly polymorphic cytochrome p450 2D6 (CYP2D6) permits a gross classification of individual phenotype (viz. ultra-rapid, extensive, and poor metabolizers). It does not, however, provide a precise prediction of CYP2D6 activity, part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75489ed8760fec0407f08382bc54d7a
https://doi.org/10.1124/dmd.31.9.1103
https://doi.org/10.1124/dmd.31.9.1103
Publikováno v:
Epilepsy Research. 35:253-255
CYP2C9 is mainly responsible for the metabolic clearance of phenytoin and (S)-warfarin. We have shown previously that mutations in the CYP2C9 gene are associated with diminished metabolism of (S)-warfarin, and so we have now studied the metabolism of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be3041442b0618fabc28c3cde1ee5b5
https://doi.org/10.1016/s0920-1211(99)00017-0
https://doi.org/10.1016/s0920-1211(99)00017-0
Autor:
Lisa, McConnachie, Miklos, Bodor, Kris, Kowdley, Adam, Levy, Bruce, Tung, Kenneth, Thummel, Brian, Phillips, Manoj, Bajpai, Victor, Chi, Joel D, Esmay, Danny D, Shen, Rodney J Y, Ho
Publikováno v:
Clinical pharmacology and therapeutics. 75(4)
The goal of this study was to develop and validate a cytochrome P450 (CYP) 2D6 probe substrate with improved sensitivity to elucidate the relationship of CYP2D6 ribonucleic acid transcript levels, genotype, and enzyme activity in human liver biopsy s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc509154b1cc108273cb17823ce3c907
https://pubmed.ncbi.nlm.nih.gov/15060507
https://pubmed.ncbi.nlm.nih.gov/15060507
Autor:
Manoj Bajpai, Joel Esmay
Publikováno v:
Drug metabolism reviews. 34(4)
In vitro drug metabolism studies play a dual role along the path from drug discovery to preclinical development. By analyzing the objectives of each type of study the question of whether to apply good laboratory practices (GLP) requirements is clarif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3a8953cb059dffa4bced92b6ea69fc
https://pubmed.ncbi.nlm.nih.gov/12487146
https://pubmed.ncbi.nlm.nih.gov/12487146
Autor:
Gregory D. Bennett, Bogdan J. Wlodarczyk, Manoj Bajpai, Richard H. Finnell, René H. Levy, Gary G. Mather
Publikováno v:
Reproductive toxicology (Elmsford, N.Y.). 13(2)
Purpose: Previous studies have suggested that polytherapy by design may aid in the management of human pregnancies complicated by epilepsy. However, mechanistic parallels must be drawn between the models of teratogenesis and human pregnancies, and do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad15eebce6cb116c209d7808dc0e094
https://pubmed.ncbi.nlm.nih.gov/10213515
https://pubmed.ncbi.nlm.nih.gov/10213515
Autor:
Richard H. Finnell, René H. Levy, Benny M. Amore, John T. Slattery, Manoj Bajpai, Gregory D. Bennett
Publikováno v:
Teratology. 52(6)
A model using SWV mice was developed to investigate the mechanistic basis of carbamazepine (CBZ)-related fetotoxicity. Drug administration was initiated prior to conception and continued until day 18 of gestation. The incidence of malformation was 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3e458fc46a9a55a82452b7e34fd96f
https://pubmed.ncbi.nlm.nih.gov/8711619
https://pubmed.ncbi.nlm.nih.gov/8711619
Publikováno v:
Drug Metabolism and Disposition; September 2003, Vol. 31 Issue: 9 p1103-7, 5p