Identification of Flavonoids as Inhibitors of Plasmodium falciparum Enoyl-ACP Reductase by Hierarchical Virtual Screening

Autor: Larissa de Mattos Oliveira, Diego Mota da Costa, Aníbal de Freitas Santos Jr., Dayse A. A. Silva, Manoelito C. dos Santos Jr., Clayton Q. Alves, Hugo Neves Brandão

Publikováno v: Journal of the Brazilian Chemical Society v.31 n.12 2020
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ
Journal of the Brazilian Chemical Society, Volume: 31, Issue: 12, Pages: 2544-2552, Published: 14 DEC 2020

Malaria, a parasitic infection caused by Plasmodium falciparum, is a serious global public health problem. The enzyme enoyl-acyl carrier protein (ACP) reductase present in a limiting step in the biosynthesis of fatty acids type II was used to search

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0fbb67f40b33bac70c0b6ff143a6c3a
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020001202544

Homology modelling of pyrophosphosrylase, enzyme involved in chitin pathway of Moniliophthora perniciosa

Autor: Sandra Aparecida de Assis, Manoelito C. dos Santos Jr., Aristóteles Góes-Neto, Alex Gutterres Taranto

Publikováno v: International Journal of Bioinformatics Research and Applications. 5:133

Moniliophthora perniciosa (Sthael) (Singer) Phillips-Mora is the causal agent of witches' broom disease, which can infect Theobroma cacao decreasing the production of cocoa about 60%. M. perniciosa has a set of potential enzymes that can be useful ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::268fafaccb81dd25d60135f1c6b758cf
https://doi.org/10.1504/ijbra.2009.024033