New series of 3-pyridyl-1,3-thiazoles: In vitro and in vivo anti-Trypanosomatidae profile, in vitro and in silico mechanism of action approach.

Autor: Gouveia de Melo Silva V; Laboratory of Planning in Medicinal Chemistry, Department of Pharmaceutical Sciences, Center for Health Sciences, Federal University of Pernambuco, 50740-535, Recife, PE, Brazil., Manoel da Silva Sousa L; Laboratory of Planning in Medicinal Chemistry, Department of Pharmaceutical Sciences, Center for Health Sciences, Federal University of Pernambuco, 50740-535, Recife, PE, Brazil., Fernandes Junior EL; Laboratory of Planning in Medicinal Chemistry, Department of Pharmaceutical Sciences, Center for Health Sciences, Federal University of Pernambuco, 50740-535, Recife, PE, Brazil., Brondani GL; Laboratory of Planning in Medicinal Chemistry, Department of Pharmaceutical Sciences, Center for Health Sciences, Federal University of Pernambuco, 50740-535, Recife, PE, Brazil., Maria de Albuquerque Oliveira I; Laboratory of Planning in Medicinal Chemistry, Department of Pharmaceutical Sciences, Center for Health Sciences, Federal University of Pernambuco, 50740-535, Recife, PE, Brazil., Galindo Bedor DC; Pharmaceutical and Cosmetic Development Center, Department of Pharmaceutical Sciences, Center for Health Sciences, Federal University of Pernambuco, 50740-535, Recife, PE, Brazil., Pereira Lopes IB; Pharmaceutical and Cosmetic Development Center, Department of Pharmaceutical Sciences, Center for Health Sciences, Federal University of Pernambuco, 50740-535, Recife, PE, Brazil., Brayner FA; Laboratory of Immunopathology and Molecular Biology, Department of Immunology, Aggeu Magalhães Institute, Fundação Oswaldo Cruz, 50670-420, Recife, PE, Brazil; Instituto Keizo Asami (iLIKA), Campus UFPE, 50670-901, Recife, PE, Brazil., Alves LC; Laboratory of Immunopathology and Molecular Biology, Department of Immunology, Aggeu Magalhães Institute, Fundação Oswaldo Cruz, 50670-420, Recife, PE, Brazil; Instituto Keizo Asami (iLIKA), Campus UFPE, 50670-901, Recife, PE, Brazil., Kaique de Andrade Cavalcante M; Laboratory of Parasitology, Academic Center of Vitória (CAV), Federal University of Pernambuco, Vitória de Santo Antão, 55608-680, PE, Brazil., Santana de Souza Oliveira D; Laboratory of Immunopathology and Molecular Biology, Department of Immunology, Aggeu Magalhães Institute, Fundação Oswaldo Cruz, 50670-420, Recife, PE, Brazil., Accioly Brelaz-de-Castro MC; Laboratory of Immunopathology and Molecular Biology, Department of Immunology, Aggeu Magalhães Institute, Fundação Oswaldo Cruz, 50670-420, Recife, PE, Brazil; Laboratory of Parasitology, Academic Center of Vitória (CAV), Federal University of Pernambuco, Vitória de Santo Antão, 55608-680, PE, Brazil., Sales Junior PA; Laboratory of Immunopathology and Molecular Biology, Department of Immunology, Aggeu Magalhães Institute, Fundação Oswaldo Cruz, 50670-420, Recife, PE, Brazil., Alves Pereira VR; Laboratory of Immunopathology and Molecular Biology, Department of Immunology, Aggeu Magalhães Institute, Fundação Oswaldo Cruz, 50670-420, Recife, PE, Brazil., Lima Leite AC; Laboratory of Planning in Medicinal Chemistry, Department of Pharmaceutical Sciences, Center for Health Sciences, Federal University of Pernambuco, 50740-535, Recife, PE, Brazil. Electronic address: ana.lleite@ufpe.br.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2024 Dec 20; Vol. 284, pp. 117191. Date of Electronic Publication: 2024 Dec 20.