Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Manny M Semonis"'
Autor:
Damien M Rasmussen, Manny M Semonis, Joseph T Greene, Joseph M Muretta, Andrew R Thompson, Silvia Toledo Ramos, David D Thomas, William CK Pomerantz, Tanya S Freedman, Nicholas M Levinson
Publikováno v:
eLife, Vol 13 (2024)
The type II class of RAF inhibitors currently in clinical trials paradoxically activate BRAF at subsaturating concentrations. Activation is mediated by induction of BRAF dimers, but why activation rather than inhibition occurs remains unclear. Using
Externí odkaz:
https://doaj.org/article/908aea3f4eb7430b8ef82e94417a536d
Autor:
Damien M. Rasmussen, Manny M. Semonis, Joseph M. Muretta, Andrew R. Thompson, David D. Thomas, William C.K. Pomerantz, Nicholas M. Levinson
Publikováno v:
bioRxiv
Both first-generation αC-out and newer αC-in RAF inhibitors paradoxically activate BRAF kinase at subsaturating concentrations. Paradoxical activation by αC-in inhibitors is linked to the formation of BRAF dimers, but why activation rather than in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be22b6affe409fae8cfbcfc0f229d60
https://doi.org/10.1101/2023.04.18.536450
https://doi.org/10.1101/2023.04.18.536450
Autor:
Rahul Banerjee, Manny M. Semonis, John D. Lipscomb, William C. K. Pomerantz, Jason C. Jones, Ke Shi, Hideki Aihara
Publikováno v:
Biochemistry
Soluble methane monooxygenase (sMMO) is a multicomponent metalloenzyme capable of catalyzing the fissure of the C-H bond of methane and the insertion of one atom of oxygen from O2 to yield methanol. Efficient multiple-turnover catalysis occurs only i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f6c94f5c59c6c75af80957585d369a8
https://doi.org/10.1021/acs.biochem.1c00293
https://doi.org/10.1021/acs.biochem.1c00293
Autor:
Rasmussen, Damien M., Semonis, Manny M., Greene, Joseph T., Muretta, Joseph M., Thompson, Andrew R., Ramos, Silvia Toledo, Thomas, David D., Pomerantz, William C. K., Freedman, Tanya S., Levinson, Nicholas M.
Publikováno v:
eLife; 5/14/2024, p1-22, 22p