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Akademický článek

Soluble CD25 imposes a low-zone IL-2 signaling environment that favors competitive outgrowth of antigen-experienced CD25 ^high regulatory and memory T cells.

Autor: Nickle RA; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, USA. Electronic address: rebecca.nickle@biolegend.com., DeOca KB; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, USA. Electronic address: kayla.b.deoca@gmail.com., Garcia BL; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, USA. Electronic address: garciabr18@ecu.edu., Mannie MD; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, USA. Electronic address: manniem@ecu.edu.

Publikováno v: Cellular immunology [Cell Immunol] 2023 Feb; Vol. 384, pp. 104664. Date of Electronic Publication: 2023 Jan 05.

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Akademický článek

Hypoxia-inducible factor-1 drives divergent immunomodulatory functions in the pathogenesis of autoimmune diseases.

Autor: Islam SMT; Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA., Won J; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA., Khan M; Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA., Mannie MD; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, USA., Singh I; Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.; Ralph H. Johnson VA Medical Center, Charleston, SC, USA.

Publikováno v: Immunology [Immunology] 2021 Sep; Vol. 164 (1), pp. 31-42. Date of Electronic Publication: 2021 Apr 27.

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Akademický článek

Nature's carriers: leveraging extracellular vesicles for targeted drug delivery.

Autor: Chen, Qi¹ (AUTHOR) cq-chem@zju.edu.cn, Zheng, Yuyi² (AUTHOR), Jiang, Xuhong³ (AUTHOR), Wang, Yi^2,4 (AUTHOR), Chen, Zhong^2,3 (AUTHOR), Wu, Di² (AUTHOR) wudichem@zju.edu.cn

Publikováno v: Drug Delivery. Dec2024, Vol. 31 Issue 1, p1-16. 16p.

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Akademický článek

Low-Zone IL-2 Signaling: Fusion Proteins Containing Linked CD25 and IL-2 Domains Sustain Tolerogenic Vaccination in vivo and Promote Dominance of FOXP3 ⁺ Tregs in vitro .

Autor: DeOca KB; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, United States., Moorman CD; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, United States., Garcia BL; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, United States., Mannie MD; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2020 Sep 23; Vol. 11, pp. 541619. Date of Electronic Publication: 2020 Sep 23 (Print Publication: 2020).

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Akademický článek

Tolerogenic vaccines: Targeting the antigenic and cytokine niches of FOXP3 ⁺ regulatory T cells.

Autor: Mannie MD; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, United States. Electronic address: manniem@ecu.edu., DeOca KB; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, United States., Bastian AG; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, United States., Moorman CD; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, United States.

Publikováno v: Cellular immunology [Cell Immunol] 2020 Sep; Vol. 355, pp. 104173. Date of Electronic Publication: 2020 Jul 15.

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Akademický článek

A GM-CSF-neuroantigen tolerogenic vaccine elicits inefficient antigen recognition events below the CD40L triggering threshold to expand CD4 ⁺ CD25 ⁺ FOXP3 ⁺ Tregs that inhibit experimental autoimmune encephalomyelitis (EAE).

Autor: Moorman CD; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA., Bastian AG; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA., DeOca KB; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA., Mannie MD; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA. manniem@ecu.edu.

Publikováno v: Journal of neuroinflammation [J Neuroinflammation] 2020 Jun 10; Vol. 17 (1), pp. 180. Date of Electronic Publication: 2020 Jun 10.

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Akademický článek

A GMCSF-Neuroantigen Tolerogenic Vaccine Elicits Systemic Lymphocytosis of CD4 ⁺ CD25 ^high FOXP3 ⁺ Regulatory T Cells in Myelin-Specific TCR Transgenic Mice Contingent Upon Low-Efficiency T Cell Antigen Receptor Recognition.

Autor: Moorman CD; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, United States., Curtis AD 2nd; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, United States., Bastian AG; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, United States., Elliott SE; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, United States., Mannie MD; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2019 Jan 10; Vol. 9, pp. 3119. Date of Electronic Publication: 2019 Jan 10 (Print Publication: 2018).

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Akademický článek

Partial CD25 Antagonism Enables Dominance of Antigen-Inducible CD25 ^high FOXP3 ⁺ Regulatory T Cells As a Basis for a Regulatory T Cell-Based Adoptive Immunotherapy.

Autor: Wilkinson DS; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, United States., Ghosh D; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, United States., Nickle RA; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, United States., Moorman CD; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, United States., Mannie MD; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2017 Dec 14; Vol. 8, pp. 1782. Date of Electronic Publication: 2017 Dec 14 (Print Publication: 2017).

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