Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Mannen MISHIMA"'
2
Studies on the Metabolic Fate of Flecainide Acetate. (1). Blood Levels, Distribution, Metabolism and Excretion in Rats after Repeated Intravenous Administration
Autor: Atsushi Takao, Atsuhiro Inaba, Masataka Ueda, Hiromi Moriki, Mannen Mishima, Teruaki Yuzuriha, Manami Taguchi, Keiko Kamiya, Hironobu Kiriya
Publikováno v: Drug Metabolism and Pharmacokinetics. 14:201-213
Blood and plasma concentration-time profile, distribution, metabolism, excretion of radioactivity after a single intravenous administration of 14C-Flecainide acetate at a dose of 2 mg/kg to dogs, and in vitro and in vivo plasma protein binding were s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::abc2f47da7694c6d6aced91156598207
https://doi.org/10.2133/dmpk.14.201
Zobrazit plný text záznamu
3
Identification of the metabolites of a new oxazolidinone MAO-A inhibitor in rat
Autor: Teruaki Yuzuriha, Toru Horie, T Kozaki, Mannen Mishima, M Kakiki, T Naitoh
Publikováno v: Xenobiotica. 27:1071-1089
1. Six metabolites present in rat urine after the oral administration of E2011 ((5R)-3-[2-((1S)-3-cyano-1-hydroxypropyl)benzothiazol-6-yl]-5-meth oxymethyl-2- oxazolidinone) were isolated with an Amberlite XAD-4 column and hplc, and termed HPM-1, HPM
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3e7d4309fb787563464daa2a97053b
https://doi.org/10.1080/004982597240037
Zobrazit plný text záznamu
4
Studies on the Metabolic Fate of Modified Recombinant Tissu-Type Plasminogen Activator (E6010) (3): Feto-Placental Transfer and Excretion into Milk in Rats after a Single Intravenous Administration of l25I-E6010
Autor: Teruaki Yuzuriha, Tomomi Ando, Yoshiko Kagei, Mannen Mishima, Hitoshi Mizuo
Publikováno v: Drug Metabolism and Pharmacokinetics. 11:599-606
The feto-placental transfer of 125I-E6010 and the excretion into milk were studied in pregnant and lactating rats after a single intravenous administration of 0.4 mg/kg of 125I-E6010. 1. At 15 min after a single intravenous administration of 125I-E60
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e00017986603b6b349f275d591d6166e
https://doi.org/10.2133/dmpk.11.599
Zobrazit plný text záznamu
5
Studies on the Metabolic Fate of Modified Recombinant Tissu-Type Plasminogen Activator (E6010) (2): Blood or Plasma Concentration, Distribution, Metabolism and Excretion in Rats after Repeated Intravenous Administration of 125I-E6010
Autor: Masataka Ueda, Hitoshi Mizuo, Kiyomi Kikuchi, Teruaki Yuzuriha, Mannen Mishima
Publikováno v: Drug Metabolism and Pharmacokinetics. 11:585-598
Blood or plasma concentration, distribution, metabolism and excretion of E6010 were studied in male rats during and after repeated daily intravenous administration of 0.4 mg/kg of 125I-E6010 for 10 days. 1. At 5 min after the repeated intravenous adm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c797a425c87e639a0f1c1924aa84058d
https://doi.org/10.2133/dmpk.11.585
Zobrazit plný text záznamu
7
Synthesis of 14C or 3H-labelled indometacin farnesil (E-0710)
Autor: Mannen Mishima, Chihiro Yamato, Shinya Abe, Isao Yamatsu, Seiichi Kobayashi
Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 29:619-624
A 14C or 3H-labelled, 7:3 (2E:2Z) isomeric mixture of 6E-3, 7, 11-trimethyl-2, 6, 10-dodecatrienyl-1-(p-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate (indometacin farnesil; IMF), a prodrug of indomethacin, was synthesized in order to study th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba141a59180336321b253ce63a1e0531
https://doi.org/10.1002/jlcr.2580290602
Zobrazit plný text záznamu
8
Studies on the Metabolic Fate of Indometacin Farnesil. (IV): Anti-inflamatory Action and Distribution into Inflamed Site in Dogs
Autor: Hitoshi Mizuo, Seiichi Kobayashi, Teruaki Yuzuriha, Tadashi Sato, Mannen Mishima, Shinya Abe, Kenji Matsui
Publikováno v: Drug Metabolism and Pharmacokinetics. 6:615-626
An analgesic efficacy of IMF and the metabolism were examined after oral administration of 14C-labelled indometacin farnesil (IMF) in the dog arthritis model, and were compared with those of indomethacin (IND). 1. IMF have shown the analgesic effect
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::102c1b67109899ee3be4260be61335e4
https://doi.org/10.2133/dmpk.6.615
Zobrazit plný text záznamu
9
Synthesis of 14C-labelled 6-hydroxy-5,7-dimethyl-2-(methylamino)-4-(3-pyridylmethyl)benzothiazole dihydrochloride (14C-E3040 dihydrochloride)
Autor: Numata Hirotoshi, Osamu Takenaka, Shigeki Hibi, Mannen Mishima, Yasushi Okamoto
Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 36:445-447
14 C-Labelled 6-hydroxy-5,7-dimethyl-2-(methylamino)-4-(3-pyridylmethyl)-benzothiazole dihydrochloride ( 14 C-E3040 dihydrochloride), required for a study of the pharmacokinetic profile of E3040, a novel dual inhibitor of 5-lipoxygenase and thromboxa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8cf9987e8ba6f9d591244370d50424c7
https://doi.org/10.1002/jlcr.2580360507
Zobrazit plný text záznamu
10
Absorption, distribution, metabolism and excretion of a new, 14C-labelled oxazolidinone MAO-A inhibitor in rat and dog
Autor: Mannen Mishima, T Naitoh, Toru Horie, M Kakiki, S Kawaguchi, K Kagei, Teruaki Yuzuriha, T Andoh, Kenji Matsui
Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 27(10)
1. After oral administration of 14C-labelled (5R)-3-[2-((1S)-3-cyano-1-hydroxypropyl)benzothiazol-6-yl]-5-metho xymethyl -2-oxazolidinone (E2011) at a dose of 1 mg/kg, the blood level of radioactivity reached a maximum concentration (Cmax) of 0.545 m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6606881bd5d7b64d1cbb0d343e5c5e8c
https://pubmed.ncbi.nlm.nih.gov/9364742
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje