Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mann-Yan Kuo"'
Publikováno v:
Molecular Cancer Therapeutics. 18:C046-C046
The hedgehog (Hh) pathway is a critical embryonic signaling cascade regulating cell growth, proliferation and differentiation. Hh signaling is significantly less active in adult tissues, where its primary role appears to be the maintenance of stem ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6542575ebac34504676c8b1d6d7bf126
https://doi.org/10.1158/1535-7163.targ-19-c046
https://doi.org/10.1158/1535-7163.targ-19-c046
Autor:
Mann-Yan Kuo, Shao-Zheng Peng, Sian-Yi Ciou, Ju-Ying Yang, Yen-Hsi Liu, Chu-Bin Liao, Hung-Jyun Huang, Shih Chieh Yen
Publikováno v:
Cancer Research. 78:2809-2809
The oncogenic mutations of BRAF which occur most frequently in V600E, leading to constitutive activation of the MAPK signaling pathway, are common in a variety of human cancers. Recently, drugs targeting RAF kinase have been approved as an effective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f50edc8e4a3c598acebe3a8f074af72e
https://doi.org/10.1158/1538-7445.am2018-2809
https://doi.org/10.1158/1538-7445.am2018-2809
Autor:
Yu-Wen Tseng, Yann-Yu Lu, Mann-Yan Kuo, Chu-Bin Liao, Shian-Yi Chiou, Chia Wei Liu, Ying-Shuan Lee, Her Sheng Lin, Shao-Zheng Pen, Win Yin Wei
Publikováno v:
Cancer Research. 77:134-134
The Hedgehog (Hh) signaling pathway is a critical regulator of embryonic patterning, and aberrant Hh pathway activation has been implicated in a diverse spectrum of cancers. Therefore, components of the Shh pathway (such as Shh, SMO, and GLI1/2) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fb69950bd82bcd2bf8c8a8a6745e183
https://doi.org/10.1158/1538-7445.am2017-134
https://doi.org/10.1158/1538-7445.am2017-134
Autor:
Mann-Yan Kuo, Richard C. Larock
Publikováno v:
ChemInform. 22
The palladium-catalyzed coupling of allylic alcohols and o -iodoaniline provides a convenient, one-step synthesis of quinolines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b431be45c00d27b0d427a3d31dd0968
https://doi.org/10.1002/chin.199150153
https://doi.org/10.1002/chin.199150153
Autor:
Richard C. Larock, Mann-Yan Kuo
Publikováno v:
Tetrahedron Letters. 32:569-572
The palladium-catalyzed coupling of allylic alcohols and o -iodoaniline provides a convenient, one-step synthesis of quinolines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d399f58ae074dfc3698eeef297455fa8
https://doi.org/10.1016/s0040-4039(00)74829-5
https://doi.org/10.1016/s0040-4039(00)74829-5
Autor:
Ying-Shuan E. Lee, Pan-Chyr Yang, Yen His Liu, Y.-Y. Lu, Chih-Hsin Yang, Shian-Yi Chiou, Yu-Wen Tseng, Yu Jie Lin, Li Jung Chen, Mann-Yan Kuo, Yi-Ting Huang
Publikováno v:
Molecular Cancer Therapeutics. 12:C270-C270
The mammalian target of rapamycin (mTOR) is a highly conserved Ser/Thr protein kinase and a central controller of cell growth, proliferation, and survival. Studies have linked the hyperactive PI3K-AKT-mTOR signaling pathway in a variety of human canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1554b39e540b1717a93fa4d1f1ee39ae
https://doi.org/10.1158/1535-7163.targ-13-c270
https://doi.org/10.1158/1535-7163.targ-13-c270
Autor:
Mann-Yan Kuo, Kwang-Ting Liu
Publikováno v:
Tetrahedron. 44:3523-3530
Solvolysis of 2-aryl-3,3-dimethyl-2-butyl p -nitrobenzoates (4a-4d) and the 1,1,1-trideuterio derivatives (5a, 5b, 5c) in HFIP exhibited a high kinetic isotope effect, k(CH3)/k(CD3) = 1.90 at 60°C for the deactivating substrates 4c vs 5c. This effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7cc4e8cf45722b8e12cc69db45ec7fa
https://doi.org/10.1016/s0040-4020(01)85982-2
https://doi.org/10.1016/s0040-4020(01)85982-2
Autor:
Mann-Yan Kuo, Kwang-Ting Liu
Publikováno v:
Tetrahedron Letters. 26:355-358
In the titled system the remarkably high tosylate/bromide solvolysis rate ratio of 1.56 × 106 : 1 indicates a highly strained ground state, and the reverse order of reactivity for substrate having 1-(4-trifluoromethyl)phenyl vs. that having 1-(3-tri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c18c78d4ab26dea01154f64593c8f405
https://doi.org/10.1016/s0040-4039(01)80816-9
https://doi.org/10.1016/s0040-4039(01)80816-9
Publikováno v:
Journal of the American Chemical Society. 104:211-215
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be946cba1fb784e966fc5a3a6fc496e5
https://doi.org/10.1021/ja00365a038
https://doi.org/10.1021/ja00365a038
Publikováno v:
Journal of Physical Organic Chemistry. 1:241-245
The rates of solvolysis of I-aryl-l-phenyl-2,2-dimethylpropyl(l) p-nitrobenzoates and of aryldiphenylmethyl-p-nitrobenzoates (2) were measured in 80% acetone. An inverse order of reactivity, kp-~&,.~~, > I was observed for 1 but not for 2. The X-ray
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d800d99aa5d3c5f587786914eec968e
https://doi.org/10.1002/poc.610010407
https://doi.org/10.1002/poc.610010407