Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Manmohan Reddy Leleti"'
Autor:
Dillon H. Miles, Ada Chen, Manmohan Reddy Leleti, Divyank Soni, Stephen W Young, Artur K. Mailyan, Kenneth V. Lawson, Stefan G Shaqfeh, Ehesan U. Sharif, Jenna L. Jeffrey, Jesus Banuelos, Xuelei Yan, Samuel L Drew, Kimberline Gerrick, Nigel Walker, Puja Dhanota, Lixia Jin, Jay P. Powers, Elaine Ginn, Guillaume Mata, Kent Wong, Hema Singh, Jeremy Fournier, Joel W. Beatty, Ulrike Schindler, Amber Pham, Matthew J. Walters, Jie Chen, Cesar Meleza, Xiaoning Zhao, Nell Narasappa
Publikováno v:
Journal of Medicinal Chemistry. 65:1418-1444
Phosphoinositide-3-kinase γ (PI3Kγ) is highly expressed in immune cells and promotes the production and migration of inflammatory mediators. The inhibition of PI3Kγ has been shown to repolarize the tumor immune microenvironment to a more inflammat
Autor:
Dillon H. Miles, Nigel Walker, Manmohan Reddy Leleti, Xiaoning Zhao, Eric T. Newcomb, Kenneth V. Lawson, Jaroslaw Kalisiak, Erick Allen Lindsey, Lixia Jin, Ada Chen, Laurent Debien, Guifen Xu, Ehesan U. Sharif, Norbert Sträter, Brandon Reid Rosen, Stephen W Young, Emma Scaletti, Jay P. Powers
Publikováno v:
Journal of Medicinal Chemistry. 64:845-860
Solid tumors are often associated with high levels of extracellular ATP. Ectonucleotidases catalyze the sequential hydrolysis of ATP to adenosine, which potently suppresses T-cell and NK-cell functions via the adenosine receptors (A2a and A2b). The e
Autor:
Manmohan Reddy Leleti, Jeremy Fournier, Steven D. Jacob, Eric F. Connor, Grange Rebecca Louise, Kenneth V. Lawson, Anh Tran, Jaroslaw Kalisiak, Jay P. Powers, Xuelei Yan
Publikováno v:
Organic Process Research & Development. 25:157-162
AB680 is a highly potent CD73 small molecule inhibitor discovered and developed by Arcus Biosciences, currently in clinical trials for the treatment of pancreatic cancer. Here, we report the develo...
Autor:
Dillon H. Miles, Ada Chen, Manmohan Reddy Leleti, Divyank Soni, Stephen W Young, Artur K. Mailyan, Kenneth V. Lawson, Stefan G Shaqfeh, Ehesan U. Sharif, Pei-Yu Chen, Jenna L. Jeffrey, Jesus Banuelos, Xuelei Yan, Samuel L Drew, Nigel Walker, Puja Dhanota, Lixia Jin, Jay P. Powers, Elaine Ginn, Guillaume Mata, Kent Wong, Jeremy Fournier, Joel W. Beatty, Rhiannon Thomas-Tran, Ulrike Schindler, Amber Pham, Matthew J. Walters, Jie Chen, Cesar Meleza, Xiaoning Zhao
Publikováno v:
Journal of Medicinal Chemistry. 63:11235-11257
The selective inhibition of the lipid signaling enzyme PI3Kγ constitutes an opportunity to mediate immunosuppression and inflammation within the tumor microenvironment but is difficult to achieve due to the high sequence homology across the class I
Autor:
Brandon Reid Rosen, Manmohan Reddy Leleti, Ada Chen, Sharon Zhao, Jenna L. Jeffrey, Norbert Sträter, Eric T. Newcomb, Jay P. Powers, Kenneth V. Lawson, Lijuan Fu, Dillon H. Miles, Uli Schindler, Wade Berry, Stephen W Young, Tim Park, Emma Scaletti, Lixia Jin, Joanne B.L. Tan, Ehesan U. Sharif, Laurent Debien, Erick Allen Lindsey, Jaroslaw Kalisiak, Susanne Moschütz, Matthew J. Walters, Guifen Xu, Nigel Walker
Publikováno v:
Journal of Medicinal Chemistry. 63:11448-11468
Extracellular adenosine (ADO), present in high concentrations in the tumor microenvironment (TME), suppresses immune function via inhibition of T cell and NK cell activation. Intratumoral generation of ADO depends on the sequential catabolism of ATP
Autor:
Jenna L. Jeffrey, Laurent Debien, Dillon H. Miles, Manmohan Reddy Leleti, Brandon Reid Rosen, Jay P. Powers, Ehesan U. Sharif
Publikováno v:
Organic Process Research & Development. 24:1254-1261
AB928 is a potent and selective dual antagonist of the A2a and A2b receptors, which is currently in clinical trials. Here, we report the development of two scalable and practical syntheses of AB928...
Autor:
Stephen W Young, Debashis Mandal, Sharon Zhao, Susanne Moschütz, Ada Chen, Elaine Ginn, Lixia Jin, Samuel L Drew, Nigel Walker, Erick Allen Lindsey, Jay P. Powers, Kenneth V. Lawson, Xuelei Yan, Anh Tran, Rhiannon Thomas-Tran, Amber Pham, Manmohan Reddy Leleti, Jenna L. Jeffrey, Steven D. Jacob, Norbert Sträter, Joel W. Beatty, Jeremy Fournier, Laurent Debien
Publikováno v:
Journal of Medicinal Chemistry. 63:3935-3955
CD73 is an extracellular mediator of purinergic signaling. When upregulated in the tumor microenvironment, CD73 has been implicated in the inhibition of immune function through overproduction of adenosine. Traditional efforts to inhibit CD73 have inv
Autor:
Jean Chan, Lixia Jin, Kelsey Sivick Gauthier, Stephen W Young, Matthew J. Walters, Balint Gal, Anh Tran, Kenneth V. Lawson, Elaine Ginn, Manmohan Reddy Leleti, Jennie Au, Soonweng Cho, Dana Piovesan, Xiaoning Zhao, Akshata Udyavar, Jay P. Powers, Ada Chen, Cesar Meleza, Brandon Reid Rosen, Samuel L Drew
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background The microenvironment of solid tumors is hypoxic and requires induction of genes associated with metabolism, growth, proliferation, and angiogenesis for cancer cells to survive and metastasize. The master transcriptional regulators of hypox
Autor:
Stephen W. Young, Guillaume Mata, Joel W. Beatty, Matthew J. Walters, Kelsey Sivick Gauthier, Jeremy Fournier, Jennifer Au, Jay P. Powers, Dana Piovesan, Artur K. Mailyan, Kenneth V. Lawson, Manmohan Reddy Leleti, Elaine Ginn, Jarek Kalisiak, Xuelei Yan, Balint Gal, Zhang Wang, Lixia Jin, Samuel L Drew, Cesar Meleza
Publikováno v:
Cancer Research. 81:1206-1206
A hypoxic environment is a common characteristic of solid tumors. Cancer cells adapt to hypoxia and become more aggressive by up-regulation of genes associated with metabolism, growth, proliferation, angiogenesis, and erythropoiesis. Hypoxia-inducibl
Autor:
D. Miles, C.N. Foley, Jay P. Powers, Matthew J. Walters, R. Grange, Manmohan Reddy Leleti, Y. Chen, X. Zhao, Lixia Jin, Steve Young, S.L. Paprcka
Publikováno v:
European Journal of Cancer. 138:S38-S39