Zobrazeno 1 - 10
of 270
pro vyhledávání: '"Manlio Palumbo"'
Publikováno v:
ARKIVOC, Vol 2004, Iss 5, Pp 204-218 (2004)
Externí odkaz:
https://doaj.org/article/0ed6353e8cb84d809351025d9599f5e4
Autor:
Silvia Da Ros, Eleonora Zorzan, Mery Giantin, Lara Zorro Shahidian, Manlio Palumbo, Mauro Dacasto, Claudia Sissi
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103876 (2014)
Downregulation of gene expression by induction of non-canonical DNA structures at promotorial level is a novel attractive anticancer strategy. In human, two guanine-rich sequences (h_kit1 and h_kit2) were identified in the promotorial region of oncog
Externí odkaz:
https://doaj.org/article/c047fd252dd2497d96aa64573b5c85dc
Autor:
Giovanna Sattin, Anna Artese, Matteo Nadai, Giosuè Costa, Lucia Parrotta, Stefano Alcaro, Manlio Palumbo, Sara N Richter
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84113 (2013)
Telomeres are guanine-rich sequences that protect the ends of chromosomes. These regions can fold into G-quadruplex structures and their stabilization by G-quadruplex ligands has been employed as an anticancer strategy. Genetic analysis in human telo
Externí odkaz:
https://doaj.org/article/0aa5f76182e54237b1cbacc3382d07da
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58529 (2013)
The physiological role(s) played by G-quadruplexes renders these 'non-canonical' DNA secondary structures interesting new targets for therapeutic intervention. In particular, the search for ligands for selective recognition and stabilization of G-qua
Externí odkaz:
https://doaj.org/article/cdb5d662e5814e3ba7389f1523df69bd
Autor:
Rosalba Perrone, Matteo Nadai, Jerrod A Poe, Ilaria Frasson, Manlio Palumbo, Giorgio Palù, Thomas E Smithgall, Sara N Richter
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e73121 (2013)
G-quadruplexes are tetraplex structures of nucleic acids that can form in G-rich sequences. Their presence and functional role have been established in telomeres, oncogene promoters and coding regions of the human chromosome. In particular, they have
Externí odkaz:
https://doaj.org/article/24f856fea414412cadb23b059038d14d
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52994 (2012)
Non-canonical DNA structures have been postulated to mediate protein-nucleic acid interactions and to function as intermediates in the generation of frame-shift mutations when errors in DNA replication occur, which result in a variety of diseases and
Externí odkaz:
https://doaj.org/article/7fae12d419404a33899bce607f06a450
Autor:
Manlio Palumbo, Claudia Sissi
Publikováno v:
Nucleic Acids in Medicinal Chemistry and Chemical Biology. :483-510
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a0fc043ad135da24fb0fee5d697d0d3
https://doi.org/10.1002/9781119692799.ch14
https://doi.org/10.1002/9781119692799.ch14
Autor:
Manlio Palumbo, Claudia Sissi
Publikováno v:
Handbook of Chemical Biology of Nucleic Acids ISBN: 9789811613135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e80c434d279730806a9f3c27835d4c93
https://doi.org/10.1007/978-981-16-1313-5_39-1
https://doi.org/10.1007/978-981-16-1313-5_39-1
Autor:
Manlio Palumbo, Claudia Sissi
Publikováno v:
International Journal of Molecular Sciences. 23:11984
Winning the war against cancer represents a major goal currently [...]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::863a2527204dd0d294a5a95aa338ee0f
https://doi.org/10.3390/ijms231911984
https://doi.org/10.3390/ijms231911984
Autor:
Manlio, Palumbo, Claudia, Sissi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 69:128787
This paper deals with a critical examination on the possibility of quantitatively predicting the in vivo activity of new chemical entities (NCEs) by making use of in silico and in vitro data including three-dimensional structure of drug-target comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f16cdfddf4e035054ba6433adf4e03c
https://doi.org/10.1016/j.bmcl.2022.128787
https://doi.org/10.1016/j.bmcl.2022.128787