Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Manlio Bolla"'
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35196 (2012)
Nonsteroidal anti-inflammatory drugs are among the most commonly used prescription and over-the-counter medications, but they often produce significant gastrointestinal ulceration and bleeding, particularly in elderly patients and patients with certa
Externí odkaz:
https://doaj.org/article/47cd3880c38646378f5f637668b5f5dc
Autor:
Saske Hoving, Sylvia Heeneman, Marion J J Gijbels, Johannes A M te Poele, Manlio Bolla, Jeffrey F C Pol, Michelle Y Simons, Nicola S Russell, Mat J Daemen, Fiona A Stewart
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12874 (2010)
BACKGROUND: We previously showed that irradiation to the carotid arteries of ApoE(-/-) mice accelerated the development of macrophage-rich, inflammatory atherosclerotic lesions, prone to intra-plaque hemorrhage. In this study we investigated the pote
Externí odkaz:
https://doaj.org/article/e8822741e0044f10a63b5ad47abd9469
Autor:
Anna Tesei, Francesco Fabbri, Marco Rosetti, Rosella Silvestrini, Carlo Leonetti, Wainer Zoli, Dino Amadori, Manlio Bolla
Publikováno v:
Nitric Oxide. 19:225-236
Non-steroidal anti-inflammatory drugs (NSAIDs) have repeatedly shown to be effective in tumor prevention, but important side-effects limit their wide clinical use. Nitric oxide-releasing derivatives (NO-NSAIDs) are a promising class of compounds synt
Autor:
Manlio Bolla, Ennio Ongini
Publikováno v:
Drug Discovery Today: Therapeutic Strategies. 3:395-400
Concerns have been raised regarding cardiovascular safety of anti-inflammatory agents, both selective cyclooxygenase (COX-2) inhibitors and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs). We describe the emerging new class of COX-inhibiti
Autor:
Dino Amadori, Wainer Zoli, Carlo Leonetti, Marco Rosetti, Manlio Bolla, Anna Tesei, Gabriella Zupi, Francesco Fabbri, Laura Medri, Lorenzo Cecconetto, Marco Scarsella, Paola Ulivi
Publikováno v:
Molecular Cancer Therapeutics. 5:919-926
We previously showed that NCX 4040 inhibits in vitro and in vivo tumor growth and induces apoptosis in human colon cancer cell lines. On the basis of these results, NCX 4040 antitumor activity in combination with 5-fluorouracil (5-FU) or oxaliplatin
Publikováno v:
European Journal of Clinical Pharmacology. 62:145-154
In more than a century of use, the benefits of aspirin have been exploited in different therapeutic areas, from inflammation to cardiovascular disease for which it is an approved treatment for acute coronary heart disease and a recommended treatment
Autor:
Marco Rosetti, Sara Bravaccini, Francesco Fabbri, Ivan Vannini, Manlio Bolla, Anna Tesei, Wainer Zoli, Giovanni Brigliadori, Dino Amadori, Paola Ulivi
Publikováno v:
Apoptosis. 10:1095-1103
Nitric oxide-releasing non steroidal anti-inflammatory drugs (NO-NSAIDs) are a promising class of compounds that cause cell cycle perturbations and induce apoptosis in cell lines from different tumors. We investigated the activity of a recently devel
Publikováno v:
Current Topics in Medicinal Chemistry. 5:707-720
Organic nitrates, such as nitroglycerin, have been used in clinical practice for more than one century for the treatment of angina, even before the identification of Nitric Oxide (NO) as the so-called Endothelium Derived Relaxing Factor (EDRF). Recen
Autor:
Sandra Huguenin, Jean-Pierre Riffaud, Marie-Claude Jaurand, Jocelyne Fleury-Feith, Manlio Bolla, Dominique K. Chopin, Francis Vacherot
Publikováno v:
Cancer Letters. 218:163-170
Our work aimed at identifying the antitumoral potential of new nitric oxide (NO)-releasing non-steroidal anti-inflammatory drug (NSAID) derivatives on human prostate and bladder carcinoma cell lines. Among all molecules tested, two sulindac derivativ
Autor:
Sylviane Levy-Toledano, Bernard I. Levy, Laurent Loufrani, Manlio Bolla, Aida Habib, Dong You, Daniel Henrion
Publikováno v:
Hypertension. 43:1264-1269
The influence of cyclooxygenase pathway activation following thromboxane-endoperoxide (TP) receptor stimulation was studied in rat mesenteric resistance arteries (n=6 to 10 per group). We studied isolated, perfused, and pressurized mesenteric resista