Výsledky vyhledávání - "Manlio Alessi"

Tetraethylphosphorodiamidate-Directed Metalation Group: Directed Ortho and Remote Metalation, Cross Coupling, and Remote Phospha Anionic Fries Rearrangement Reactions

Autor: Tom Blackburn, Manlio Alessi, Hannah Sawinski, Jignesh J. Patel, Victor Snieckus

Publikováno v: Organic Letters. 22:3860-3864

The linked directed ortho and remote metalation (DoM and DreM) and cross-coupling reactions of aryl phosphorodiamidates (Ar-OP(O)(NEt2)2) is reported. The o-iodo and o-boronato aryl tetraethylphosp...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd3e7f5c26154fddb79a264e0249c6f9
https://doi.org/10.1021/acs.orglett.0c01123

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The Tetraethylphosphorodiamidate (OP(O)(NEt2)2) Directed Metalation Group (DMG). Directed ortho and Lateral Metalation and the Phospha Anionic Fries Rearrangement

Autor: Kristina Zumbansen, Jignesh J. Patel, Manlio Alessi, Victor Snieckus

Publikováno v: Organic Letters. 22:2147-2151

We report on the tetraethylphosphorodiamidate (−OP(O)(NEt2)2) group as an effective directed metalation group (DMG). Lithiation-electrophile quench of 1 provides a general synthesis of ortho-substi...

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https://doi.org/10.1021/acs.orglett.0c00094

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On the Mechanism of the Directed ortho and Remote Metalation Reactions of N,N-Dialkylbiphenyl 2-carboxamides

Autor: Victor Snieckus, Anne-Sophie Castanet, David Tilly, Manlio Alessi, Bao-ping Zhao, Jian-min Fu, Jacques Mortier

Publikováno v: Organic Letters
Organic Letters, American Chemical Society, 2010, 12 (1), pp.68-71. ⟨10.1021/ol902268h⟩

A study concerning the mechanism of the LDA-mediated ortho and remote metalation of N,N-dialkyl-2-biphenyl carboxamides (e.g., 4a) is reported. On the basis of site-selective lithiation/electrophile quench experiments, including deuteration, the LDA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e79077a5d89c632c7c6ff9d28578217d
https://doi.org/10.1021/ol902268h

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Directed ortho Metalation−Boronation and Suzuki−Miyaura Cross Coupling of Pyridine Derivatives: A One-Pot Protocol to Substituted Azabiaryls

Autor: Andrew L. Larkin, Sunny Lai, Kevin Ogilvie, Manlio Alessi, Laine Green, Victor Snieckus, Simón E. López

Publikováno v: The Journal of Organic Chemistry. 72:1588-1594

A general method for the synthesis of azabiaryls 19a-t by a one-pot procedure involving a Directed ortho metalation (DoM)-boronation-Suzuki-Miyaura cross coupling sequence is described. Aside from the three isomeric pyridyl carboxamides 15a-c, chloro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5244d620d6949521f1eee32690da6182
https://doi.org/10.1021/jo0620359

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Susceptibility to Aflatoxin B1-Induced Carcinogenesis Correlates with Tissue-Specific Differences in DNA Repair Activity in Mouse and in Rat

Autor: Manlio Alessi, Thomas E. Massey, Scott Davey, Leanne L. Bedard

Publikováno v: Cancer Research. 65:1265-1270

To investigate the mechanisms responsible for species- and tissue-specific differences in susceptibility to aflatoxin B1 (AFB1)–induced carcinogenesis, DNA repair activities of nuclear extracts from whole mouse lung and liver and rat liver were com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e46313f80bb7d7be8b3bd7e20e44180
https://doi.org/10.1158/0008-5472.can-04-3373

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The Contrasting Kinetics of Peroxidation of Vitamin E-Containing Phospholipid Unilamellar Vesicles and Human Low-Density Lipoprotein1

Autor: Thomas Paul, Manlio Alessi, K. U. Ingold, J. C. Scaiano

Publikováno v: Journal of the American Chemical Society. 124:6957-6965

It is well established that α-tocopherol, TocH, is an outstanding lipid-soluble, peroxyl radical trapping antioxidant in homogeneous systems. It is also well established that TocH functions as a prooxidant in human low-density lipoprotein, LDL, subj

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https://doi.org/10.1021/ja0127178

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ChemInform Abstract: Stereoselective Synthesis of Isoxazole and Pyrazole Annulated Sultams via Intramolecular 1,3-Dipolar Cycloaddition Reactions

Autor: Giovanni Romeo, Manlio Alessi, Venerando Pistarà, Roberto Romeo, Antonino Corsaro, Anna Piperno, Giuseppe Gumina, Ugo Chiacchio, Antonio Rescifina

Publikováno v: ChemInform. 29

Functionalized isothiazoloisoxazole-4,4-dioxide, pyrazoloisothiazole-1,1-dioxide, [1,2]thiazinoisoxazole-4,4-dioxide and benzo[1,2]thiazinoisoxazole-4,4-dioxide systems have been obtained by intramolecular 1,3-dipolar cycloaddition, starting from sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::edb75f1879646b9a75c581f8a4a0f86a
https://doi.org/10.1002/chin.199807150

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Directed ortho-Metalation—Boronation and Suzuki—Miyaura Cross-Coupling of Pyridine Derivatives: A One-Pot Protocol to Substituted Azabiaryls

Autor: Manlio Alessi, Laine Green, Victor Snieckus, Sunny Lai, Simón E. López, Kevin Ogilvie, Andrew L. Larkin

Publikováno v: ChemInform. 38

A general method for the synthesis of azabiaryls 19a−t by a one-pot procedure involving a Directed ortho metalation (DoM)−boronation−Suzuki−Miyaura cross coupling sequence is described. Aside from the three isomeric pyridyl carboxamides 15a�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df3c16e78f3c3d7852d43b9420e79b44
https://doi.org/10.1002/chin.200728135

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