A Targeted, Bioinert LC-MS/MS Method for Sensitive, Comprehensive Analysis of Signaling Lipids.

Autor: Rubenzucker S; Department of Analytical Chemistry, University of Vienna, 1090 Vienna, Austria.; Vienna Doctoral School in Chemistry, University of Vienna, 1090 Vienna, Austria., Manke MC; DFG Heisenberg Group Cardiovascular Thromboinflammation and Translational Thrombocardiology, University of Tübingen, 72076 Tübingen, Germany.; Department of Cardiology and Angiology, University of Tübingen, 72076 Tübingen, Germany., Lehmann R; Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine, University Hospital Tübingen, 72076 Tübingen, Germany., Assinger A; Department of Vascular Biology and Thrombosis Research, Centre of Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria., Borst O; DFG Heisenberg Group Cardiovascular Thromboinflammation and Translational Thrombocardiology, University of Tübingen, 72076 Tübingen, Germany.; Department of Cardiology and Angiology, University of Tübingen, 72076 Tübingen, Germany., Ahrends R; Department of Analytical Chemistry, University of Vienna, 1090 Vienna, Austria.

Publikováno v: Analytical chemistry [Anal Chem] 2024 Jun 11; Vol. 96 (23), pp. 9643-9652. Date of Electronic Publication: 2024 May 25.

Critical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation.

Autor: de Jonckheere B; Institute of Analytical Chemistry, University of Vienna, Austria.; Vienna Doctoral School in Chemistry, University of Vienna, Austria., Kollotzek F; DFG Heisenberg Group Cardiovascular Thromboinflammation and Translational Thrombocardiology, University of Tübingen, Germany.; Department of Cardiology and Angiology, University of Tübingen, Germany., Münzer P; DFG Heisenberg Group Cardiovascular Thromboinflammation and Translational Thrombocardiology, University of Tübingen, Germany.; Department of Cardiology and Angiology, University of Tübingen, Germany., Göb V; Institute for Experimental Biomedicine, University Hospital Würzburg, Germany.; Rudolf Virchow Center for Integrative and Translational Bioimaging, Würzburg, Germany., Fischer M; DFG Heisenberg Group Cardiovascular Thromboinflammation and Translational Thrombocardiology, University of Tübingen, Germany.; Department of Cardiology and Angiology, University of Tübingen, Germany., Mott K; Institute for Experimental Biomedicine, University Hospital Würzburg, Germany., Coman C; Institute of Analytical Chemistry, University of Vienna, Austria., Troppmair NN; Institute of Analytical Chemistry, University of Vienna, Austria.; Vienna Doctoral School in Chemistry, University of Vienna, Austria., Manke MC; DFG Heisenberg Group Cardiovascular Thromboinflammation and Translational Thrombocardiology, University of Tübingen, Germany.; Department of Cardiology and Angiology, University of Tübingen, Germany., Zdanyte M; DFG Heisenberg Group Cardiovascular Thromboinflammation and Translational Thrombocardiology, University of Tübingen, Germany.; Department of Cardiology and Angiology, University of Tübingen, Germany., Harm T; Department of Cardiology and Angiology, University of Tübingen, Germany., Sigle M; Department of Cardiology and Angiology, University of Tübingen, Germany., Kopczynski D; Institute of Analytical Chemistry, University of Vienna, Austria., Bileck A; Institute of Analytical Chemistry, University of Vienna, Austria.; Joint Metabolome Facility, University of Vienna and Medical University of Vienna, Austria., Gerner C; Institute of Analytical Chemistry, University of Vienna, Austria.; Joint Metabolome Facility, University of Vienna and Medical University of Vienna, Austria., Hoffmann N; Forschungszentrum Jülich GmbH, Institute for Bio- and Geosciences (IBG-5) Jülich, Germany.; Institute of Analytical Chemistry, University of Vienna, Austria., Heinzmann D; Department of Cardiology and Angiology, University of Tübingen, Germany., Assinger A; Institute of Physiology, Centre of Physiology and Pharmacology, Medical University of Vienna, Austria., Gawaz M; Department of Cardiology and Angiology, University of Tübingen, Germany., Stegner D; Institute for Experimental Biomedicine, University Hospital Würzburg, Germany.; Rudolf Virchow Center for Integrative and Translational Bioimaging, Würzburg, Germany., Schulze H; Institute for Experimental Biomedicine, University Hospital Würzburg, Germany., Borst O; DFG Heisenberg Group Cardiovascular Thromboinflammation and Translational Thrombocardiology, University of Tübingen, Germany.; Department of Cardiology and Angiology, University of Tübingen, Germany., Ahrends R; Institute of Analytical Chemistry, University of Vienna, Austria.

Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2023 Sep; Vol. 2, pp. 835-852. Date of Electronic Publication: 2023 Aug 31.

Platelet-Derived MicroRNAs Regulate Cardiac Remodeling After Myocardial Ischemia.

Autor: Schütte JP; DFG Heisenberg Research Group Thrombocardiology and Cardiovascular Thrombo-Inflammation (J.P.S., M.-C.M., P.M., F.K., M.Z., O.B.), University Hospital of Tübingen, Germany.; Department of Cardiology, Angiology and Cardiovascular Medicine (J.P.S., M.-C.M., P.M., V.D., F.K., M.Z., K.A.L.M., M.G., O.B.), University Hospital of Tübingen, Germany., Manke MC; DFG Heisenberg Research Group Thrombocardiology and Cardiovascular Thrombo-Inflammation (J.P.S., M.-C.M., P.M., F.K., M.Z., O.B.), University Hospital of Tübingen, Germany.; Department of Cardiology, Angiology and Cardiovascular Medicine (J.P.S., M.-C.M., P.M., V.D., F.K., M.Z., K.A.L.M., M.G., O.B.), University Hospital of Tübingen, Germany., Hemmen K; Rudolf Virchow Center for Translation and Integrative Bioimaging (K.H., J.P., B.N., K.G.H.), University of Würzburg, Germany., Münzer P; DFG Heisenberg Research Group Thrombocardiology and Cardiovascular Thrombo-Inflammation (J.P.S., M.-C.M., P.M., F.K., M.Z., O.B.), University Hospital of Tübingen, Germany.; Department of Cardiology, Angiology and Cardiovascular Medicine (J.P.S., M.-C.M., P.M., V.D., F.K., M.Z., K.A.L.M., M.G., O.B.), University Hospital of Tübingen, Germany., Schörg BF; Department of Preclinical Imaging and Radiopharmacy, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation (B.F.S., S.H.L.H., B.P.), University of Tübingen, Germany., Ramos GC; Department of Internal Medicine I (G.C.R.), University Hospital of Würzburg, Germany.; Comprehensive Heart Failure Center (G.C.R.), University Hospital of Würzburg, Germany., Pogoda M; Institute of Medical Genetics and Applied Genomics (M.P., Y.S., N.C.), University of Tübingen, Germany.; NGS Competence Center Tübingen, Germany (M.P., N.C.)., Dicenta V; Department of Cardiology, Angiology and Cardiovascular Medicine (J.P.S., M.-C.M., P.M., V.D., F.K., M.Z., K.A.L.M., M.G., O.B.), University Hospital of Tübingen, Germany., Hoffmann SHL; Department of Preclinical Imaging and Radiopharmacy, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation (B.F.S., S.H.L.H., B.P.), University of Tübingen, Germany., Pinnecker J; Rudolf Virchow Center for Translation and Integrative Bioimaging (K.H., J.P., B.N., K.G.H.), University of Würzburg, Germany., Kollotzek F; DFG Heisenberg Research Group Thrombocardiology and Cardiovascular Thrombo-Inflammation (J.P.S., M.-C.M., P.M., F.K., M.Z., O.B.), University Hospital of Tübingen, Germany.; Department of Cardiology, Angiology and Cardiovascular Medicine (J.P.S., M.-C.M., P.M., V.D., F.K., M.Z., K.A.L.M., M.G., O.B.), University Hospital of Tübingen, Germany., Zdanyte M; DFG Heisenberg Research Group Thrombocardiology and Cardiovascular Thrombo-Inflammation (J.P.S., M.-C.M., P.M., F.K., M.Z., O.B.), University Hospital of Tübingen, Germany.; Department of Cardiology, Angiology and Cardiovascular Medicine (J.P.S., M.-C.M., P.M., V.D., F.K., M.Z., K.A.L.M., M.G., O.B.), University Hospital of Tübingen, Germany., Mueller KAL; Department of Cardiology, Angiology and Cardiovascular Medicine (J.P.S., M.-C.M., P.M., V.D., F.K., M.Z., K.A.L.M., M.G., O.B.), University Hospital of Tübingen, Germany., Singh Y; Institute of Medical Genetics and Applied Genomics (M.P., Y.S., N.C.), University of Tübingen, Germany.; Institute of Physiology (Y.S., F.L.), University of Tübingen, Germany., Mack AF; Institute of Clinical Anatomy and Cell Analysis (A.F.M.), University of Tübingen, Germany., Pichler B; Department of Preclinical Imaging and Radiopharmacy, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation (B.F.S., S.H.L.H., B.P.), University of Tübingen, Germany., Lang F; Institute of Physiology (Y.S., F.L.), University of Tübingen, Germany., Nieswandt B; Rudolf Virchow Center for Translation and Integrative Bioimaging (K.H., J.P., B.N., K.G.H.), University of Würzburg, Germany.; Institute of Experimental Biomedicine I (B.N.), University of Würzburg, Germany., Gawaz M; Department of Cardiology, Angiology and Cardiovascular Medicine (J.P.S., M.-C.M., P.M., V.D., F.K., M.Z., K.A.L.M., M.G., O.B.), University Hospital of Tübingen, Germany., Heinze KG; Rudolf Virchow Center for Translation and Integrative Bioimaging (K.H., J.P., B.N., K.G.H.), University of Würzburg, Germany., Casadei N; Institute of Medical Genetics and Applied Genomics (M.P., Y.S., N.C.), University of Tübingen, Germany.; NGS Competence Center Tübingen, Germany (M.P., N.C.)., Borst O; DFG Heisenberg Research Group Thrombocardiology and Cardiovascular Thrombo-Inflammation (J.P.S., M.-C.M., P.M., F.K., M.Z., O.B.), University Hospital of Tübingen, Germany.; Department of Cardiology, Angiology and Cardiovascular Medicine (J.P.S., M.-C.M., P.M., V.D., F.K., M.Z., K.A.L.M., M.G., O.B.), University Hospital of Tübingen, Germany.

Publikováno v: Circulation research [Circ Res] 2023 Mar 31; Vol. 132 (7), pp. e96-e113. Date of Electronic Publication: 2023 Mar 09.

ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury.

Autor: Rohlfing AK; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany., Kolb K; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany., Sigle M; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany., Ziegler M; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany., Bild A; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany., Münzer P; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany., Sudmann J; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany., Dicenta V; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany., Harm T; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany., Manke MC; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany.; DFG Heisenberg Group Thrombocardiology, University of Tübingen, Tübingen, Germany., Geue S; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany., Kremser M; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany., Chatterjee M; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany., Liang C; Department of Bioinformatics, Biocenter, University of Würzburg, Würzburg, Germany., von Eysmondt H; Institute of Applied Physics, University of Tübingen, Tübingen, Germany., Dandekar T; Department of Bioinformatics, Biocenter, University of Würzburg, Würzburg, Germany., Heinzmann D; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany., Günter M; Department of Dendritic Cells in Infection and Cancer, German Cancer Research Centre, Heidelberg, Germany., von Ungern-Sternberg S; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany., Büttcher M; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany., Castor T; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany., Mencl S; Department of Neurology, University Hospital Essen, Essen, Germany., Langhauser F; Department of Neurology, University Hospital Essen, Essen, Germany., Sies K; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Dermatology, University of Heidelberg, Heidelberg, Germany., Ashour D; Immunocardiology Lab, University Hospital Würzburg, Comprehensive Heart Failure Center (CHFC), Würzburg, Germany., Beker MC; Department of Physiology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey., Lämmerhofer M; University of Tübingen, Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-)Analysis, Tübingen, Germany., Autenrieth SE; Department of Dendritic Cells in Infection and Cancer, German Cancer Research Centre, Heidelberg, Germany., Schäffer TE; Institute of Applied Physics, University of Tübingen, Tübingen, Germany., Laufer S; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, University of Tübingen, Tübingen, Germany., Szklanna P; Conway-SPHERE Research Group, Conway Institute, University College Dublin, Dublin, Ireland., Maguire P; Conway-SPHERE Research Group, Conway Institute, University College Dublin, Dublin, Ireland., Heikenwalder M; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Müller KAL; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany., Hermann DM; Vascular Neurology, Dementia and Ageing Research, Department of Neurology, Essen, Germany., Kilic E; Department of Physiology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey., Stumm R; Institute of Pharmacology and Toxicology, Jena University Hospital, Jena, Germany., Ramos G; Immunocardiology Lab, University Hospital Würzburg, Comprehensive Heart Failure Center (CHFC), Würzburg, Germany., Kleinschnitz C; Department of Neurology, University Hospital Essen, Essen, Germany., Borst O; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany.; DFG Heisenberg Group Thrombocardiology, University of Tübingen, Tübingen, Germany., Langer HF; University Hospital, Medical Clinic II, University Heart Center, Lübeck, Germany.; DZHK (German Research Centre for Cardiovascular Research), Partner Site Hamburg/Lübeck/Kiel, Lübeck, Germany., Rath D; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany., Gawaz M; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany. meinrad.gawaz@med.uni-tuebingen.de.

Publikováno v: Nature communications [Nat Commun] 2022 Apr 05; Vol. 13 (1), pp. 1823. Date of Electronic Publication: 2022 Apr 05.

ANXA7 Regulates Platelet Lipid Metabolism and Ca ²⁺ Release in Arterial Thrombosis.

Autor: Manke MC; Department of Cardiology, Angiology and Cardiovascular Medicine (M.-C.M., S.G., F.K., P.M., B.W., D.R., M.G., O.B.), University of Tübingen, Germany.; DFG Heisenberg Group Thrombocardiology (M.-C.M., F.K., P.M., O.B.)., Geue S; Department of Cardiology, Angiology and Cardiovascular Medicine (M.-C.M., S.G., F.K., P.M., B.W., D.R., M.G., O.B.), University of Tübingen, Germany., Coman C; Department of Analytical Chemistry, University of Vienna, Austria (C.C., R.A.)., Peng B; Division of Rheumatology, Department of Medicine Solna, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden (B.P.).; Leibniz-Institut für Analytische Wissenschaften - ISAS, Dortmund, Germany (B.P., A.S., R.A.)., Kollotzek F; Department of Cardiology, Angiology and Cardiovascular Medicine (M.-C.M., S.G., F.K., P.M., B.W., D.R., M.G., O.B.), University of Tübingen, Germany.; DFG Heisenberg Group Thrombocardiology (M.-C.M., F.K., P.M., O.B.)., Münzer P; Department of Cardiology, Angiology and Cardiovascular Medicine (M.-C.M., S.G., F.K., P.M., B.W., D.R., M.G., O.B.), University of Tübingen, Germany.; DFG Heisenberg Group Thrombocardiology (M.-C.M., F.K., P.M., O.B.)., Walker B; Department of Cardiology, Angiology and Cardiovascular Medicine (M.-C.M., S.G., F.K., P.M., B.W., D.R., M.G., O.B.), University of Tübingen, Germany., Huber SM; Department of Radiation Oncology (S.M.H.), University of Tübingen, Germany., Rath D; Department of Cardiology, Angiology and Cardiovascular Medicine (M.-C.M., S.G., F.K., P.M., B.W., D.R., M.G., O.B.), University of Tübingen, Germany., Sickmann A; Leibniz-Institut für Analytische Wissenschaften - ISAS, Dortmund, Germany (B.P., A.S., R.A.)., Stegner D; Institute of Experimental Biomedicine, University Hospital and Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Germany (D.S., B.N.)., Duerschmied D; Heart Center, Faculty of Medicine, University of Freiburg, Germany (D.D.)., Lang F; Department of Physiology (F.L.), University of Tübingen, Germany., Nieswandt B; Institute of Experimental Biomedicine, University Hospital and Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Germany (D.S., B.N.)., Gawaz M; Department of Cardiology, Angiology and Cardiovascular Medicine (M.-C.M., S.G., F.K., P.M., B.W., D.R., M.G., O.B.), University of Tübingen, Germany., Ahrends R; Department of Analytical Chemistry, University of Vienna, Austria (C.C., R.A.).; Leibniz-Institut für Analytische Wissenschaften - ISAS, Dortmund, Germany (B.P., A.S., R.A.)., Borst O; Department of Cardiology, Angiology and Cardiovascular Medicine (M.-C.M., S.G., F.K., P.M., B.W., D.R., M.G., O.B.), University of Tübingen, Germany.; DFG Heisenberg Group Thrombocardiology (M.-C.M., F.K., P.M., O.B.).

Publikováno v: Circulation research [Circ Res] 2021 Aug 06; Vol. 129 (4), pp. 494-507. Date of Electronic Publication: 2021 Jun 28.