Expression of membrane Hsp90 is a molecular signature of T cell activation

Autor: Scott A. Scarneo, Aaron P. Smith, Jacob Favret, Robert O’Connell, Joy Pickeral, Kelly W. Yang, Guido Ferrari, David R. Loiselle, Philip F. Hughes, Manjusha M. Kulkarni, Madhusudhana Gargesha, Bryan Scott, Debashish Roy, Barton F. Haynes, Jesse J. Kwiek, Timothy A. J. Haystead

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Abstract Heat shock protein 90 (Hsp90) maintains cellular proteostasis during stress and has been under investigation as a therapeutic target in cancer for over two decades. We and others have identified a membrane expressed form of Hsp90 (mHsp90) th

Externí odkaz: https://doaj.org/article/7498fd35bf0d43599a354d885b957978

Cellular fatty acid synthase is required for late stages of HIV-1 replication

Autor: Manjusha M. Kulkarni, Annette N. Ratcliff, Menakshi Bhat, Yazan Alwarawrah, Philip Hughes, Jesus Arcos, David Loiselle, Jordi B. Torrelles, Nicholas T. Funderburg, Timothy A. Haystead, Jesse J. Kwiek

Publikováno v: Retrovirology, Vol 14, Iss 1, Pp 1-12 (2017)

Abstract Background Like all viruses, HIV-1 relies on host systems to replicate. The human purinome consists of approximately two thousand proteins that bind and use purines such as ATP, NADH, and NADPH. By virtue of their purine binding pockets, pur

Externí odkaz: https://doaj.org/article/198c703fa7b643ab9fcf74aba658487f

In Vitro Exposure of Leukocytes to HIV Preexposure Prophylaxis Decreases Mitochondrial Function and Alters Gene Expression Profiles.

Autor: Bowman ER; The Ohio State University, Columbus, Ohio, USA Emily.Bowman@osumc.edu., Cameron C; Case Western Reserve University, Cleveland, Ohio, USA., Richardson B; Case Western Reserve University, Cleveland, Ohio, USA., Kulkarni M; The Ohio State University, Columbus, Ohio, USA., Gabriel J; The Ohio State University, Columbus, Ohio, USA., Kettelhut A; The Ohio State University, Columbus, Ohio, USA., Hornsby L; The Ohio State University, Columbus, Ohio, USA., Kwiek JJ; The Ohio State University, Columbus, Ohio, USA., Turner AN; The Ohio State University, Columbus, Ohio, USA., Malvestutto C; The Ohio State University, Columbus, Ohio, USA., Bazan J; The Ohio State University, Columbus, Ohio, USA., Koletar SL; The Ohio State University, Columbus, Ohio, USA., Doblecki-Lewis S; University of Miami, Miami, Florida, USA., Lederman MM; Case Western Reserve University, Cleveland, Ohio, USA., Cameron M; Case Western Reserve University, Cleveland, Ohio, USA., Klatt NR; Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA., Lake JE; The University of Texas Health Science Center, Houston, Texas, USA., Funderburg NT; The Ohio State University, Columbus, Ohio, USA.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2020 Dec 16; Vol. 65 (1). Date of Electronic Publication: 2020 Dec 16 (Print Publication: 2020).

Macrophage maturation from blood monocytes is altered in people with HIV, and is linked to serum lipid profiles and activation indices: A model for studying atherogenic mechanisms.

Autor: Bowman ER; School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, Ohio State University, Columbus, Ohio, United States of America., Cameron CM; Department of Nutrition, Case Western Reserve University, Cleveland, Ohio, United States of America., Richardson B; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America., Kulkarni M; School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, Ohio State University, Columbus, Ohio, United States of America., Gabriel J; School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, Ohio State University, Columbus, Ohio, United States of America., Cichon MJ; Department of Food Science & Technology and the Nutrient & Phytochemical Shared Resource, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America., Riedl KM; Department of Food Science & Technology and the Nutrient & Phytochemical Shared Resource, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America., Mustafa Y; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America., Cartwright M; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America., Snyder B; School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, Ohio State University, Columbus, Ohio, United States of America., Raman SV; Department of Internal Medicine, Division of Cardiovascular Medicine, Ohio State University, Columbus, Ohio, United States of America., Zidar DA; Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States of America., Koletar SL; Department of Medicine, Division of Infectious Diseases, Ohio State University, Columbus, Ohio, United States of America., Playford MP; Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States of America., Mehta NN; Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States of America., Sieg SF; Department of Medicine, Division of Infectious Diseases and HIV Medicine, Case Western Reserve University/University Hospitals of Cleveland, Cleveland, Ohio, United States of America., Freeman ML; Department of Medicine, Division of Infectious Diseases and HIV Medicine, Case Western Reserve University/University Hospitals of Cleveland, Cleveland, Ohio, United States of America., Lederman MM; Department of Medicine, Division of Infectious Diseases and HIV Medicine, Case Western Reserve University/University Hospitals of Cleveland, Cleveland, Ohio, United States of America., Cameron MJ; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America., Funderburg NT; School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, Ohio State University, Columbus, Ohio, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2020 Oct 01; Vol. 16 (10), pp. e1008869. Date of Electronic Publication: 2020 Oct 01 (Print Publication: 2020).

Altered Intestinal Permeability and Fungal Translocation in Ugandan Children With Human Immunodeficiency Virus.

Autor: Dirajlal-Fargo S; University Hospitals Cleveland Medical Center, Columbus.; Rainbow Babies and Children's Hospital, Columbus.; Case Western Reserve University, Columbus., El-Kamari V; Case Western Reserve University, Columbus., Weiner L; Rainbow Babies and Children's Hospital, Columbus., Shan L; Case Western Reserve University, Columbus., Sattar A; Case Western Reserve University, Columbus., Kulkarni M; Ohio State University School of Health and Rehabilitation Sciences, Columbus., Funderburg N; Ohio State University School of Health and Rehabilitation Sciences, Columbus., Nazzinda R; Joint Clinical Research Centre, Kampala, Uganda., Karungi C; Joint Clinical Research Centre, Kampala, Uganda., Kityo C; Joint Clinical Research Centre, Kampala, Uganda., Musiime V; Joint Clinical Research Centre, Kampala, Uganda.; Department of Paediatrics and Child Health, Makerere University, Kampala, Uganda., McComsey GA; University Hospitals Cleveland Medical Center, Columbus.; Rainbow Babies and Children's Hospital, Columbus.; Case Western Reserve University, Columbus.

Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2020 May 23; Vol. 70 (11), pp. 2413-2422.