Small-Molecule Disruptors of the Interaction between Calcium- and Integrin-Binding Protein 1 and Integrin α IIb β 3 as Novel Antiplatelet Agents.

Autor: Golla K; Cardeza Center for Hemostasis, Thrombosis, and Vascular Biology, Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, United States., Yasgar A; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Manjuprasanna VN; Cardeza Center for Hemostasis, Thrombosis, and Vascular Biology, Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, United States., Naik MU; Cardeza Center for Hemostasis, Thrombosis, and Vascular Biology, Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, United States., Baljinnyam B; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Zakharov AV; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Jain S; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Rai G; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Jadhav A; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Simeonov A; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Naik UP; Cardeza Center for Hemostasis, Thrombosis, and Vascular Biology, Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, United States.

Publikováno v: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2024 May 29; Vol. 7 (7), pp. 1971-1982. Date of Electronic Publication: 2024 May 29 (Print Publication: 2024).

Inhibition of sPLA 2 enzyme activity by cell-permeable antioxidant EUK-8 and downregulation of p38, Akt, and p65 signals induced by sPLA 2 in inflammatory mouse paw edema model.

Autor: Jayachandra K; Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysuru, Karnataka, India., Gowda MDM; Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysuru, Karnataka, India., Rudresha GV; Evolutionary Venomics Lab, Centre for Ecological Sciences, Indian Institute of Science, Bengaluru, Karnataka, India., Manjuprasanna VN; Department of Hematology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Urs AP; Comprehensive Cancer Centre, The Ohio State University, Columbus, Ohio, USA., Nandana MB; Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysuru, Karnataka, India., Bharatha M; Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysuru, Karnataka, India., Jameel NM; Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysuru, Karnataka, India., Vishwanath BS; Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysuru, Karnataka, India.

Publikováno v: Journal of cellular biochemistry [J Cell Biochem] 2023 Feb; Vol. 124 (2), pp. 294-307. Date of Electronic Publication: 2022 Dec 31.

Drupin, a thrombin-like protease prompts platelet activation and aggregation through protease-activated receptors.

Autor: Manjuprasanna VN; Department of Studies in Biochemistry, University of Mysore, Manasagangothri, Mysuru, Karnataka, India., Urs AP; Department of Studies in Biochemistry, University of Mysore, Manasagangothri, Mysuru, Karnataka, India., Rudresha GV; Department of Studies in Biochemistry, University of Mysore, Manasagangothri, Mysuru, Karnataka, India., Milan Gowda MD; Department of Studies in Biochemistry, University of Mysore, Manasagangothri, Mysuru, Karnataka, India., Jayachandra K; Department of Studies in Biochemistry, University of Mysore, Manasagangothri, Mysuru, Karnataka, India., Hiremath V; Vijayashree Diagnostics, Specialized Coagulation Lab, Bengaluru, Karnataka, India., Rajaiah R; Department of Studies in Molecular Biology, University of Mysore, Manasagangothri, Mysuru, Karnataka, India., Vishwanath BS; Department of Studies in Biochemistry, University of Mysore, Manasagangothri, Mysuru, Karnataka, India.; Department of Studies in Molecular Biology, University of Mysore, Manasagangothri, Mysuru, Karnataka, India.

Publikováno v: Journal of cellular biochemistry [J Cell Biochem] 2021 Aug; Vol. 122 (8), pp. 870-881. Date of Electronic Publication: 2021 Mar 21.

Echis carinatus snake venom metalloprotease-induced toxicities in mice: Therapeutic intervention by a repurposed drug, Tetraethyl thiuram disulfide (Disulfiram).

Autor: Rudresha GV; Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysore, Karnataka, India., Urs AP; The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States of America., Manjuprasanna VN; Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysore, Karnataka, India., Milan Gowda MD; Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysore, Karnataka, India., Jayachandra K; Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysore, Karnataka, India., Rajaiah R; Department of Studies in Molecular Biology, University of Mysore, Manasagangotri, Mysore, Karnataka, India., Vishwanath BS; Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysore, Karnataka, India.; Department of Studies in Molecular Biology, University of Mysore, Manasagangotri, Mysore, Karnataka, India.

Publikováno v: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2021 Feb 02; Vol. 15 (2), pp. e0008596. Date of Electronic Publication: 2021 Feb 02 (Print Publication: 2021).

Serine protease from Tricosanthus tricuspidata accelerates healing of Echis carinatus venom-induced necrotic wound.

Autor: Rudresha GV; Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysore, Karnataka, India., Manjuprasanna VN; Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysore, Karnataka, India., Urs AP; Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysore, Karnataka, India., Choudhury M; Bioinformatics infrastructure facility, Gauhati University, Guwahati, Assam, India., Rajaiah R; Department of Studies in Molecular Biology, University of Mysore, Manasagangotri, Mysore, Karnataka, India. Electronic address: rajesh.r@biochemistry.uni-mysore.ac.in., Vishwanath BS; Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysore, Karnataka, India; Department of Studies in Molecular Biology, University of Mysore, Manasagangotri, Mysore, Karnataka, India. Electronic address: vishmy@biochemistry.uni-mysore.ac.in.

Publikováno v: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2020 Aug; Vol. 183, pp. 1-10. Date of Electronic Publication: 2020 May 21.