Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Manjunath K. Ramarao"'
Autor:
Megan A. Foley, M. Sherry Ku, Cheryl Nickerson-Nutter, Lihren Chen, Weiheng Wang, Manjunath K. Ramarao, Marina W.H. Shen, Debra G. Goodwin, Katherine L. Lee, Tam Steve Yik-Kai, Jaechul Shim, Mark L. Behnke, SooPeang Khor, John C. McKew, Xin Xu, Steven J. Kirincich, Frank Lovering, Frances Donahue, James D. Clark
Publikováno v:
Journal of Medicinal Chemistry. 50:1380-1400
The synthesis and structure-activity relationship of a series of indole inhibitors of cytosolic phospholipase A2alpha (cPLA2alpha, type IVA phospholipase) are described. Inhibitors of cPLA2alpha are predicted to be efficacious in treating asthma as w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4f309b58c1ad34e2e7e4cbf67afce20
https://doi.org/10.1021/jm061131z
https://doi.org/10.1021/jm061131z
Autor:
Kathryn E. Rogers, Jun Xu, Manjunath K. Ramarao, Girija Krishnamurthy, Fernando Ramirez, Adam M. Gilbert, Gary Kalgaonkar, Wade Edris, Yuren Wang, Nina Kadakia, Philip G. Jones
Publikováno v:
SLAS Discovery. 11:519-527
Fatty acid amide hydrolase (FAAH) is a membrane-associated enzyme that catalyzes the hydrolysis of several endogenous bioactive lipids, including anandamide (AEA), N-palmitoylethanolamine (PEA), oleamide, and N-oleoylethanolamine (OEA). These fatty a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430e6b33efa90aa3319854517aaa27c4
https://doi.org/10.1177/1087057106288188
https://doi.org/10.1177/1087057106288188
Autor:
Albert J. Uveges, Kathryn E. Rogers, Yuren Wang, Philip G. Jones, Manjunath K. Ramarao, Jun Xu
Publikováno v:
Analytical Biochemistry. 354:35-42
A binding assay for human fatty acid amide hydrolase (FAAH) using the scintillation proximity assay (SPA) technology is described. This SPA uses the specific interactions of [3H]R(+)-methanandamide (MAEA) and FAAH expressing microsomes to evaluate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::513f5905d6f4c160b6a6d09c108b058f
https://doi.org/10.1016/j.ab.2006.04.005
https://doi.org/10.1016/j.ab.2006.04.005
Autor:
Elizabeth Murphy, Manjunath K. Ramarao, Ning Pan, Nelson Huang, Kristen N. Bushell, Yuren Wang, James D. Clark, Marina W.H. Shen, Cara M. M. Williams
Publikováno v:
Analytical Biochemistry. 343:143-151
A novel fluorescent assay to continuously monitor fatty acid amide hydrolase (FAAH) activity that is simple, sensitive, and amenable to high-throughput screening (HTS) of compound libraries is described in this article. Stable Chinese hamster ovary (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7c1c4c2da8872b959a038e18b5042a
https://doi.org/10.1016/j.ab.2005.04.032
https://doi.org/10.1016/j.ab.2005.04.032
Autor:
Xiangjie Sun, Yuan Cheng, Li Xue, Manjunath K. Ramarao, Mei Wu, Alip Borthakur, Stuart F. Schlossman, K. V S Prasad, Fei Chu, Pramod Pandey
Publikováno v:
Proceedings of the National Academy of Sciences. 99:6925-6930
We previously cloned Siva-1 by using the cytoplasmic tail of CD27, a member of the tumor necrosis factor receptor family, as the bait in the yeast two-hybrid system. The Siva gene is organized into four exons that code for the predominant full-length
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e25e23a7ee9b8bb69f734f1277d7ecf1
https://doi.org/10.1073/pnas.102182299
https://doi.org/10.1073/pnas.102182299
Publikováno v:
Proceedings of the National Academy of Sciences. 95:4007-4012
Rapsyn, a peripheral membrane protein of skeletal muscle, clusters nicotinic acetylcholine receptors (nAChRs) at high density in the postsynaptic membrane. The mechanism of nAChR clustering by rapsyn was analyzed by expressing nAChRs in HEK293T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5019d79a598f10f047d73da41d7ae7c6
https://doi.org/10.1073/pnas.95.7.4007
https://doi.org/10.1073/pnas.95.7.4007
Publikováno v:
Journal of Biological Chemistry. 270:1873-1880
A hybrid cytochrome P450, C2MstC1, with 306 N-terminal amino acids derived from cytochrome P450 2C2 sequence and 184 C-terminal amino acids from cytochrome P450 2C1 acquires a novel progesterone 21-hydroxylase activity which is absent in the parent e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862b20299d6e5e06ed27606dea54b317
https://doi.org/10.1074/jbc.270.4.1873
https://doi.org/10.1074/jbc.270.4.1873
Autor:
Yajuan Zhao, Elizabeth Murphy, Katherine L. Lee, Marina W.H. Shen, Weili Duan, Paresh Thakker, James D. Clark, Manjunath K. Ramarao, John C. McKew, Mark Behnke
Publikováno v:
Analytical biochemistry. 383(2)
Cytosolic phospholipase A(2) alpha (cPLA(2)alpha, type IVA phospholipase) acts at the membrane surface to release free arachidonic acid, which is metabolized into inflammatory mediators, including leukotrienes and prostaglandins. Thus, specific cPLA(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1322161aad3fa1b5dc100610f1b4017b
https://pubmed.ncbi.nlm.nih.gov/18801329
https://pubmed.ncbi.nlm.nih.gov/18801329
Autor:
Manus Ipek, Cheryl L. Nickerson-Nutter, Marina W.H. Shen, Elizabeth A. Murphy, Martin Hegen, Cara Williams, Kun Wu, James C. Keith, Baihua Hu, Steven J. Kirincich, Paresh Thakker, Ronald S Michalak, Katherine L. Lee, John C. McKew, James D. Clark, Leo Albert, Steve Tam, Lihren Chen, Manjunath K. Ramarao, Yonghan Hu, Debra G. Goodwin, Xin Xu, Sum Fuk-Wah, Mark L. Behnke, Frances Donahue, Megan A. Foley, M. Sherry Ku, Jennifer Thomason, William M. Abraham, Lane Wooder
Publikováno v:
Journal of medicinal chemistry. 51(12)
The optimization of a class of indole cPLA 2 alpha inhibitors is described herein. The importance of the substituent at C3 and the substitution pattern of the phenylmethane sulfonamide region are highlighted. Optimization of these regions led to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d0ce05d3b971757ea8be4ba47a741f
https://pubmed.ncbi.nlm.nih.gov/18498150
https://pubmed.ncbi.nlm.nih.gov/18498150
Autor:
Megan A. Foley, William M. Abraham, Cheryl Nickerson-Nutter, John C. McKew, Xin Xu, Jill Nunez, Lihren Chen, Nevena Mollova, Weiheng Wang, Richard Vargas, Marina W.H. Shen, Manjunath K. Ramarao, Cara M. M. Williams, Tam Steve Yik-Kai, James D. Clark, Mark L. Behnke, Katherine L. Lee, Debra G. Goodwin
Publikováno v:
Bioorganicmedicinal chemistry. 16(3)
The synthesis and structure-activity relationship of a series of benzenesulfonamide indole inhibitors of cPLA(2)alpha are described. Substitution of the benzenesulfonamide led to analogues with 50-fold improvement in potency versus the unsubstituted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2f9896bfab342f3ef9c0eeeb3e02a1
https://pubmed.ncbi.nlm.nih.gov/17998165
https://pubmed.ncbi.nlm.nih.gov/17998165