Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Manjula Sritharan"'
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 8, p e0003952 (2015)
Pathogenic members of the genus Leptospira are the causative agents of leptospirosis, a neglected disease of public and veterinary health concern. Leptospirosis is a systemic disease that in its severest forms leads to renal insufficiency, hepatic dy
Externí odkaz:
https://doaj.org/article/be400baf5c80466aa4777155efea1cd7
Autor:
Manjula Sritharan, Mitali Choudhury, Naveen Kumar, Sasan Salimi, Nagu Prakash Prabhu, Kavya Desai, Tejaswi Naidu Koduru
Publikováno v:
BioMetals. 34:511-528
Iron-starved Mycobacterium tuberculosis utilises the carboxymycobactin-mycobactin siderophore machinery to acquire iron. These two siderophores have high affinity for ferric iron and can withdraw the metal ion from insoluble iron hydroxides and iron-
Autor:
Hampapathula Adimurthy Nagarajaram, Guruprasad Varma Konduru, Rajagopal Subramanyam, Ramurthy Gudla, Hari Parapatla, Dayananda Siddavattam, Elsin Raju Devadasu, Manjula Sritharan
Publikováno v:
Biochemical Journal. 477:2821-2840
Our previous studies have shown the existence of organophosphate hydrolase (OPH) as a part of the inner membrane associated Ton complex (ExbB/ExbD and TonB) of Sphingobium fuliginis. We now show its involvement in iron uptake by establishing direct i
Autor:
Reetika, Chaurasia, Manjula, Sritharan
Publikováno v:
Microbiology (Reading, England). 166(11)
Sphingomyelinases produced by the pathogenic members of the genus
Autor:
Jahnavi Virivinti, Manjula Sritharan, Subhakar Kandi, Mitali Choudhury, Venkataraman Sritharan
Publikováno v:
The Indian journal of tuberculosis. 69(1)
Background HupB is an iron-regulated protein essential for the growth of Mycobacterium tuberculosis inside macrophages. To investigate if HupB induced a dominant Th2 type immune response, we studied the effect of rHupB on PBMCs from TB patients and b
Publikováno v:
European Journal of Clinical Microbiology & Infectious Diseases. 37:423-433
Leptospirosis and dengue are two commonly seen infectious diseases of the tropics. Differential diagnosis of leptospirosis from dengue fever is often difficult due to overlapping clinical symptoms and lack of economically viable and easy-to-perform l
Autor:
Manjula Sritharan
Publikováno v:
Journal of Bacteriology. 198:2399-2409
Mycobacterium tuberculosis requires iron for normal growth but faces a limitation of the metal ion due to its low solubility at biological pH and the withholding of iron by the mammalian host. The pathogen expresses the Fe 3+ -specific siderophores m
Publikováno v:
The EMBO journal. 37(2)
Host cell defense against an invading pathogen depends upon various multifactorial mechanisms, several of which remain undiscovered. Here, we report a novel defense mechanism against mycobacterial infection that utilizes the histone methyltransferase
Autor:
Ejazuddin M. Khan, Kiranmayi Vemuri, K. Venkateswara Swamy, Manjula Sritharan, Subhash Padhye, Prasad Dandawate
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:5070-5075
A novel Plumbagin–Isoniazid Analog ( PLIHZ ) and its β-cyclodextrin inclusion complex ( PLIHZCD ) is prepared, characterized and evaluated for antitubercular activity under low and high iron conditions. PLIHZCD inclusion complex was characterized
Publikováno v:
Carbohydrate Polymers. 108:135-144
A series of ferrocenyl hydrazones and their β-cyclodextrin (CD) inclusion complexes were prepared and evaluated for antitubercular activity under low and high iron conditions. The inclusion complexes were characterized by Fourier Transform Infrared