Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Manjula Sritharan"'
Autor:
Manjula Sritharan, Mitali Choudhury, Naveen Kumar, Sasan Salimi, Nagu Prakash Prabhu, Kavya Desai, Tejaswi Naidu Koduru
Publikováno v:
BioMetals. 34:511-528
Iron-starved Mycobacterium tuberculosis utilises the carboxymycobactin-mycobactin siderophore machinery to acquire iron. These two siderophores have high affinity for ferric iron and can withdraw the metal ion from insoluble iron hydroxides and iron-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad933c94a49927af3fd3e646cd8be099
https://doi.org/10.1007/s10534-021-00292-2
https://doi.org/10.1007/s10534-021-00292-2
Autor:
Hampapathula Adimurthy Nagarajaram, Guruprasad Varma Konduru, Rajagopal Subramanyam, Ramurthy Gudla, Hari Parapatla, Dayananda Siddavattam, Elsin Raju Devadasu, Manjula Sritharan
Publikováno v:
Biochemical Journal. 477:2821-2840
Our previous studies have shown the existence of organophosphate hydrolase (OPH) as a part of the inner membrane associated Ton complex (ExbB/ExbD and TonB) of Sphingobium fuliginis. We now show its involvement in iron uptake by establishing direct i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6744e975ab661c8c5aa381fee28840bf
https://doi.org/10.1042/bcj20200299
https://doi.org/10.1042/bcj20200299
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 8, p e0003952 (2015)
Pathogenic members of the genus Leptospira are the causative agents of leptospirosis, a neglected disease of public and veterinary health concern. Leptospirosis is a systemic disease that in its severest forms leads to renal insufficiency, hepatic dy
Externí odkaz:
https://doaj.org/article/be400baf5c80466aa4777155efea1cd7
Autor:
Reetika, Chaurasia, Manjula, Sritharan
Publikováno v:
Microbiology (Reading, England). 166(11)
Sphingomyelinases produced by the pathogenic members of the genus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f08ed35196463687eaa96a3d18f36479
https://pubmed.ncbi.nlm.nih.gov/32985970
https://pubmed.ncbi.nlm.nih.gov/32985970
Autor:
Jahnavi Virivinti, Manjula Sritharan, Subhakar Kandi, Mitali Choudhury, Venkataraman Sritharan
Publikováno v:
The Indian journal of tuberculosis. 69(1)
Background HupB is an iron-regulated protein essential for the growth of Mycobacterium tuberculosis inside macrophages. To investigate if HupB induced a dominant Th2 type immune response, we studied the effect of rHupB on PBMCs from TB patients and b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433d7dae2a2c2b68706c10363301ce3c
https://pubmed.ncbi.nlm.nih.gov/35074158
https://pubmed.ncbi.nlm.nih.gov/35074158
Publikováno v:
European Journal of Clinical Microbiology & Infectious Diseases. 37:423-433
Leptospirosis and dengue are two commonly seen infectious diseases of the tropics. Differential diagnosis of leptospirosis from dengue fever is often difficult due to overlapping clinical symptoms and lack of economically viable and easy-to-perform l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de183ef4f73c8f6d6203804843e29db
https://doi.org/10.1007/s10096-018-3187-9
https://doi.org/10.1007/s10096-018-3187-9
Autor:
Manjula Sritharan
Publikováno v:
Journal of Bacteriology. 198:2399-2409
Mycobacterium tuberculosis requires iron for normal growth but faces a limitation of the metal ion due to its low solubility at biological pH and the withholding of iron by the mammalian host. The pathogen expresses the Fe 3+ -specific siderophores m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1437de249bd2140b653631ed4259bff0
https://doi.org/10.1128/jb.00359-16
https://doi.org/10.1128/jb.00359-16
Publikováno v:
The EMBO journal. 37(2)
Host cell defense against an invading pathogen depends upon various multifactorial mechanisms, several of which remain undiscovered. Here, we report a novel defense mechanism against mycobacterial infection that utilizes the histone methyltransferase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04fe6f3220157c77d7bf103cfd82126
https://pubmed.ncbi.nlm.nih.gov/29301860
https://pubmed.ncbi.nlm.nih.gov/29301860
Autor:
Ejazuddin M. Khan, Kiranmayi Vemuri, K. Venkateswara Swamy, Manjula Sritharan, Subhash Padhye, Prasad Dandawate
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:5070-5075
A novel Plumbagin–Isoniazid Analog ( PLIHZ ) and its β-cyclodextrin inclusion complex ( PLIHZCD ) is prepared, characterized and evaluated for antitubercular activity under low and high iron conditions. PLIHZCD inclusion complex was characterized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd611f2cc0a77fe34ef551c95ebd4072
https://doi.org/10.1016/j.bmcl.2014.09.032
https://doi.org/10.1016/j.bmcl.2014.09.032
Publikováno v:
Carbohydrate Polymers. 108:135-144
A series of ferrocenyl hydrazones and their β-cyclodextrin (CD) inclusion complexes were prepared and evaluated for antitubercular activity under low and high iron conditions. The inclusion complexes were characterized by Fourier Transform Infrared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37421e61b0a42b0a82149c0a7eace2c0
https://doi.org/10.1016/j.carbpol.2014.03.006
https://doi.org/10.1016/j.carbpol.2014.03.006