Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Manjula Senthilkumaran"'
Publikováno v:
Metabolites, Vol 14, Iss 2, p 100 (2024)
Hypoglycaemia-associated autonomic failure (HAAF) is characterised by an impairment in adrenal medullary and neurogenic symptom responses following episodes of recurrent hypoglycaemia. Here, we review the status quo of research related to the regulat
Externí odkaz:
https://doaj.org/article/cf50cbbd358a48c08d1c1556ec5a0930
Publikováno v:
International Journal of Endocrinology, Vol 2016 (2016)
Recurrent insulin-induced hypoglycaemia is a major limitation to insulin treatment in diabetes patients leading to a condition called hypoglycaemia-associated autonomic failure (HAAF). HAAF is characterised by reduced sympathoadrenal response to subs
Externí odkaz:
https://doaj.org/article/8b38c6e708a942459cc9e1f21cbd71e7
Publikováno v:
Journal of Comparative Neurology. 526:2665-2682
Low blood glucose activates brainstem adrenergic and cholinergic neurons, driving adrenaline secretion from the adrenal medulla and glucagon release from the pancreas. Despite their roles in maintaining glucose homeostasis, the distributions of insul
Autor:
Manjula Senthilkumaran, Patrick J. Mueller, Anthony J.M. Verberne, Larisa Bobrovskaya, Frank T. Spradley, Pascal Carrive, Gisele M Etelvino, Ida J. Llewellyn-Smith
Publikováno v:
The FASEB Journal. 33
Publikováno v:
Neurochemical Research. 41:1612-1624
In this study we investigated the effects of insulin-induced hypoglycaemia on tyrosine hydroxylase (TH) protein and TH phosphorylation in the adrenal gland, C1 cell group, locus coeruleus (LC) and midbrain dopaminergic cell groups that are thought to
Publikováno v:
The FASEB Journal. 32
Publikováno v:
Autonomic neuroscience : basicclinical. 210
In this study, we investigated the effects of recurrent hypoglycaemia on the adrenal catecholamine synthetic enzymes in a rat model of hypoglycaemia-associated autonomic failure (HAAF). We found that plasma adrenaline was significantly reduced by abo
Publikováno v:
Journal of chemical neuroanatomy. 70
Tyrosine hydroxylase (TH, the rate limiting-enzyme in catecholamine synthesis) is regulated acutely via phosphorylation of 3 serine residues-Ser19, 31 and 40, and chronically via changes in TH protein levels. In this study, we aimed to investigate ho