Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Manjula Schou"'
Publikováno v:
Journal of Market Access & Health Policy, Vol 12, Iss 1, Pp 5-20 (2024)
The aim of this study was to evaluate the comparative clinical effectiveness and cost-utility of the active transcutaneous Osia® System versus the passive transcutaneous Baha® Attract System for patients with conductive or mixed hearing loss or sin
Externí odkaz:
https://doaj.org/article/a5628e3036e4427a8fd3d2f4394d78b5
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-8 (2020)
Abstract Background Despite careful planning, changes to some aspects of an ongoing randomised clinical trial (RCT), with a fixed design, may be warranted. We sought to elucidate the distinction between legitimate versus illegitimate changes to serve
Externí odkaz:
https://doaj.org/article/574a6f8467914e0e9faadb761df466b8
Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 26, Iss 10, Pp 532-539 (2010)
This study was carried out to obtain information on the efficacy and safety of the controlled release formulation of the doxazosin Gastrointestinal Therapeutic System (GITS) in Taiwanese subjects with benign prostatic hyperplasia (BPH). Studies of do
Externí odkaz:
https://doaj.org/article/5e8bfe3ffc6540dfa5fdc90b562dd4c4
Publikováno v:
Statistical Methods in Medical Research. 31:2456-2469
When a clinical trial stops early for benefit, the maximum likelihood estimate (MLE) of the treatment effect may be subject to overestimation bias. Several authors have proposed adjusting for this bias using the conditional MLE, which is obtained by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e315a50b206ab66fd9b43335676f43c2
https://doi.org/10.1177/09622802221122445
https://doi.org/10.1177/09622802221122445
Autor:
Ian C Marschner, I Manjula Schou
Publikováno v:
Clinical Trials. 19:479-489
Background Adaptive platform trials allow randomized controlled comparisons of multiple treatments using a common infrastructure and the flexibility to adapt key design features during the study. Nonetheless, they have been criticized due to the pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d51216e2b0a964f949c3f0b8147cfd9
https://doi.org/10.1177/17407745221112001
https://doi.org/10.1177/17407745221112001
Autor:
I. Manjula Schou
Publikováno v:
The Journal of rheumatology. 49(9)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::887e5f53ab8fe44a2904d845695339e5
https://pubmed.ncbi.nlm.nih.gov/35569833
https://pubmed.ncbi.nlm.nih.gov/35569833
Publikováno v:
Research Synthesis Methods. 11:287-300
The CONSORT Statement says that data-driven early stopping of a clinical trial is likely to weaken the inferences that can be drawn from the trial. The GRADE guidelines go further, saying that early stopping is a study limitation that carries the ris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6113d8f7dfd84dc9f7c2cc0ee682a2d2
https://doi.org/10.1002/jrsm.1394
https://doi.org/10.1002/jrsm.1394
Publikováno v:
Contemporary clinical trials. 110
Clinical trialists may regard an observed imbalance on a prognostic covariate as sufficiently troubling to warrant action. Objective To elucidate the issues associated with selecting, and switching between, an unadjusted versus an adjusted analysis i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bfa517fee518ce0dfb1f8c2c73535f0
https://pubmed.ncbi.nlm.nih.gov/34454099
https://pubmed.ncbi.nlm.nih.gov/34454099
Publikováno v:
Trials
Trials, Vol 21, Iss 1, Pp 1-8 (2020)
Trials, Vol 21, Iss 1, Pp 1-8 (2020)
Background Despite careful planning, changes to some aspects of an ongoing randomised clinical trial (RCT), with a fixed design, may be warranted. We sought to elucidate the distinction between legitimate versus illegitimate changes to serve as a gui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4365bd3e7209de5c857dceb1377ebd8
https://pubmed.ncbi.nlm.nih.gov/32493444
https://pubmed.ncbi.nlm.nih.gov/32493444
Autor:
I. Manjula Schou, Ian C. Marschner
Publikováno v:
Biometrical Journal. 59:636-657
Randomized clinical trials comparing several treatments to a common control are often reported in the medical literature. For example, multiple experimental treatments may be compared with placebo, or in combination therapy trials, a combination ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd4a4d2905906091b922a48783e35ac5
https://doi.org/10.1002/bimj.201500230
https://doi.org/10.1002/bimj.201500230