Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Manjul Rana"'
1
Akademický článek
Androgen receptor and its splice variant, AR-V7, differentially induce mRNA splicing in prostate cancer cells
Autor: Manjul Rana, Jianrong Dong, Matthew J. Robertson, Cristian Coarfa, Nancy L. Weigel
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Prostate cancer (PCa) is dependent on the androgen receptor (AR). Advanced PCa is treated with an androgen deprivation therapy-based regimen; tumors develop resistance, although they typically remain AR-dependent. Expression of constitutivel
Externí odkaz: https://doaj.org/article/d596508e4db041fab19ab78aa8fed1fd
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2
Akademický článek
Author Correction: Androgen receptor and its splice variant, AR-V7, differentially induce mRNA splicing in prostate cancer cells
Autor: Manjul Rana, Jianrong Dong, Matthew J. Robertson, Paul Basil, Cristian Coarfa, Nancy L. Weigel
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz: https://doaj.org/article/a38ab4c701574deab78bca9c62ffb56c
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3
The pancreatic cancer immune tumor microenvironment is negatively remodeled by gemcitabine while TGF‐β receptor plus dual checkpoint inhibition maintains antitumor immune cells
Autor: Manjul Rana, Rita Kansal, Mehdi Chaib, Bin Teng, Michelle Morrrison, David Neil Hayes, Ansley G. Stanfill, David Shibata, James A. Carson, Liza Makowski, Evan S. Glazer
Publikováno v: Molecular Carcinogenesis. 61:549-557
Pancreatic ductal adenocarcinoma (PDA) tumors have a highly immunosuppressive desmoplastic tumor microenvironment (TME) where immune checkpoint inhibition (ICI) therapy has been exceptionally ineffective. Transforming growth factor-β (TGF-β) recept
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90da33d77b3eb11d76b86746a8f01f62
https://doi.org/10.1002/mc.23401
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4
Abstract B044: Bromodomain and Extra-Terminal Protein inhibition decreases pancreatic cancer proliferation via MYC-independent pathways
Autor: Manjul Rana, Rita G. Kansal, Jie Fang, Benjamin T. Allen, Jun Yang, Evan S. Glazer
Publikováno v: Cancer Research. 82:B044-B044
Introduction: The bromodomain and extra-terminal (BET) protein family contains proteins which have evolutionarily conserved bromodomains (BRDs) that specifically recognize acetylated lysine residues on the histone tails of chromatin and regulate gene
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b9566899262a5403cb002a212e0ae58
https://doi.org/10.1158/1538-7445.panca22-b044
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5
Abstract PO-090: TGF-β induced EMT gene expression is associated with promoter demethylation in pancreatic cancer
Autor: David Shibata, Manjul Rana, Rita Kansal, Evan S. Glazer, Anders Berglund, Abidemi Ajidahun, Abul Elahi
Publikováno v: Cancer Research. 81:PO-090
INTRODUCTION: Transforming growth factor-β (TGF-β), a ubiquitous molecule in pancreatic ductal adenocarcinoma (PDA) tumors, acts as a potent inducer of tumor invasion by regulating proteins involved in metastasis and driving epithelial-mesenchymal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd03b8c05197e5a97c6afddef4df7bf8
https://doi.org/10.1158/1538-7445.panca21-po-090
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6
Influence of a critical single nucleotide polymorphism on nuclear receptor PXR-promoter function
Autor: Manjul Rana, Rakesh K. Tyagi, Poonam Coshic, Ravinder Goswami
Publikováno v: Cell Biology International. 41:570-576
The Pregnane and Xenobiotic Receptor (PXR; NR1I2) is a ligand-modulated transcription factor that belongs to the nuclear receptor superfamily. It is expressed at higher levels primarily in liver and intestine as compared to the levels in several othe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87ca40713166ec28db6dfec10dd6a7b6
https://doi.org/10.1002/cbin.10744
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7
SUN-001 Analysis of Isoform Specific Differential Splicing Effects in Prostate Cancer
Autor: Cristian Coarfa, Matthew J. Robertson, Manjul Rana, Jianrong Dong, Harika Nagandla, Basil Paul, Nancy L. Weigel
Publikováno v: Journal of the Endocrine Society
The androgen receptor (AR) is a hormone activated transcription factor which is important for the growth and progression of prostate cancer (PCa). Metastatic PCa is treated with androgen deprivation therapy (ADT) based regimen but eventually, these t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409e22c761434739968b2f7c1ee21f4c
https://doi.org/10.1210/js.2019-sun-001
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10
A comprehensive analysis and functional characterization of naturally occurring non-synonymous variants of nuclear receptor PXR
Autor: Rakesh K. Tyagi, Ravinder Goswami, Samudrala Gourinath, Manjul Rana, S. Devi
Publikováno v: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1859:1183-1197
Pregnane & Xenobiotic Receptor (PXR) acts as a xenosensing transcriptional regulator of many drug metabolizing enzymes and transporters of the 'detoxification machinery' that coordinate in elimination of xenobiotics and endobiotics from the cellular
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428115984e07a53aa8a5ed7615e12ab8
https://doi.org/10.1016/j.bbagrm.2016.03.001
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