Non-Peptidic Small Molecule Components from Cone Snail Venoms

Autor: Zhenjian Lin, Joshua P. Torres, Maren Watkins, Noemi Paguigan, Changshan Niu, Julita S. Imperial, Jortan Tun, Helena Safavi-Hemami, Rocio K. Finol-Urdaneta, Jorge L. B. Neves, Samuel Espino, Manju Karthikeyan, Baldomero M. Olivera, Eric W. Schmidt

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

Venomous molluscs (Superfamily Conoidea) comprise a substantial fraction of tropical marine biodiversity (>15,000 species). Prior characterization of cone snail venoms established that bioactive venom components used to capture prey, defend against p

Externí odkaz: https://doaj.org/article/d53cb04f1077429cb543b44418d5afd0

Neuroactive Type-A γ-Aminobutyric Acid Receptor Allosteric Modulator Steroids from the Hypobranchial Gland of Marine Mollusk, Conus geographus

Autor: Shrinivasan Raghuraman, Joshua P. Torres, Baldomero M. Olivera, Ronald W. Hughen, Manju Karthikeyan, Chang-Shan Niu, Kevin Chase, Zhenjian Lin, Alan R. Light, Marco Bortolato, Jie Zhang, Lee S. Leavitt, Lili Sun, Noemi D. Paguigan, Roberto Cadeddu, Eric W. Schmidt, Christopher A. Reilly

Publikováno v: Journal of Medicinal Chemistry. 64:7033-7043

In a program to identify pain treatments with low addiction potential, we isolated five steroids, conosteroids A-E (1-5), from the hypobranchial gland of the mollusk Conus geographus. Compounds 1-5 were active in a mouse dorsal root ganglion (DRG) as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f437c0478240b76162c4f0bb243a92b
https://doi.org/10.1021/acs.jmedchem.1c00562

Neuroactive Type-A γ-Aminobutyric Acid Receptor Allosteric Modulator Steroids from the Hypobranchial Gland of Marine Mollusk

Autor: Changshan, Niu, Lee S, Leavitt, Zhenjian, Lin, Noemi D, Paguigan, Lili, Sun, Jie, Zhang, Joshua P, Torres, Shrinivasan, Raghuraman, Kevin, Chase, Roberto, Cadeddu, Manju, Karthikeyan, Marco, Bortolato, Christopher A, Reilly, Ronald W, Hughen, Alan R, Light, Baldomero M, Olivera, Eric W, Schmidt

Publikováno v: Journal of medicinal chemistry. 64(10)

In a program to identify pain treatments with low addiction potential, we isolated five steroids, conosteroids A-E (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::592f9c8f13f9f64616210a00619f3693
https://pubmed.ncbi.nlm.nih.gov/33949869

The Tunicate Metabolite 2-(3,5-Diiodo-4-methoxyphenyl)ethan-1-amine Targets Ion Channels of Vertebrate Sensory Neurons

Autor: Tosifa A. Memon, Nicole Schmitt, Jackson Carter, Kevin Chase, Noemi D. Paguigan, Yannan Yan, Shrinivasan Raghuraman, Zhenjian Lin, Eric W. Schmidt, Albebson L. Lim, Christopher A. Reilly, Bo Hjorth Bentzen, Russell W. Teichert, Manju Karthikeyan, Baldomero M. Olivera, Lee S. Leavitt, Sean Christensen

Publikováno v: Paguigan, N D, Yan, Y, Karthikeyan, M, Chase, K, Carter, J, Leavitt, L S, Lim, A L, Lin, Z, Memon, T, Christensen, S, Bentzen, B H, Schmitt, N, Reilly, C A, Teichert, R W, Raghuraman, S, Olivera, B M & Schmidt, E W 2021, ' The Tunicate Metabolite 2-(3,5-Diiodo-4-methoxyphenyl)ethan-1-amine Targets Ion Channels of Vertebrate Sensory Neurons ', ACS chemical biology, vol. 16, no. 9, pp. 1654-1662 . https://doi.org/10.1021/acschembio.1c00328

Marine tunicates produce defensive amino-acid derived metabolites, including 2-(3,5-diiodo-4-methoxyphenyl)ethan-1-amine (DIMTA), but their mechanisms of action are rarely known. Using an assay-guided approach, we found that out of the many different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9884ca44604783f84921e5567db85434
https://curis.ku.dk/ws/files/285240582/The_tunicate_metabolite_2_3_5_diiodo_4_methoxyphenyl_ethan_1_.pdf