Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Manju Kanamala"'
Publikováno v:
Pharmaceutical Development and Technology. 26:1000-1009
Conventional non-pH-sensitive liposomes for cytoplasmic delivery of protein suffer from poor efficiency. Here we investigated mannosylated pH-sensitive liposomes (MAN-PSL) for cytoplasmic delivery of protein to macrophages RAW 264.7 using PSL and non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39b40f7d8c3ab918ddbed5f80802636
https://doi.org/10.1080/10837450.2021.1969406
https://doi.org/10.1080/10837450.2021.1969406
Autor:
Gayan Heruka De Zoysa, Zimei Wu, Lisa I. Pilkington, Manju Kanamala, Jóhannes Reynisson, Krunal Patel, Vijayalekshmi Sarojini, David Barker, Kamal Patel
Publikováno v:
Journal of Medicinal Chemistry. 63:334-348
Cell-penetrating peptide conjugated peptide aldehydes Tat-A and Tat-B showed low micromolar anticancer and antifungal activities and synergistic action in combination with cisplatin and amphotericin B against cancer and fungal cells, respectively. Ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecabef97333e9b6a7c03dd8bf89dcffd
https://doi.org/10.1021/acs.jmedchem.9b01694
https://doi.org/10.1021/acs.jmedchem.9b01694
Publikováno v:
Nanomedicine. 14:1971-1989
Aim: pH-sensitive liposomes (pSL) have emerged as promising nanocarriers due to their endo/lysosome-escape abilities, however, their pH sensitivity is compromised by poly(ethylene glycol) (PEG) coating. This study investigates whether an intracellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1270b7c2e2fddf50a35e4af9772fbe3
https://doi.org/10.2217/nnm-2018-0510
https://doi.org/10.2217/nnm-2018-0510
Autor:
Christopher J. Hall, Tanja Linnerz, Manju Kanamala, Nicola Dalbeth, Zimei Wu, Jonathan W. Astin
Publikováno v:
Journal of Visualized Experiments.
Zebrafish (Danio rerio) larvae have developed into a popular model to investigate host-pathogen interactions and the contribution of innate immune cells to inflammatory disease due to their functionally conserved innate immune system. They are also w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::425cc4c51e98c3aafd1d625cb2884c58
https://doi.org/10.3791/60198-v
https://doi.org/10.3791/60198-v
Publikováno v:
Nanomedicine. 13:3083-3089
Aim: Removal of a toxin from the body once absorbed is usually not possible. We describe the use of magnetite containing pH gradient ‘MagnepH’ liposomes to overcome limitations preventing removal. Methods: MagnepH liposomes were added to albumin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40cc5b923a37de6e67729afe812f7c42
https://doi.org/10.2217/nnm-2018-0198
https://doi.org/10.2217/nnm-2018-0198
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 305
Chemoresistance poses a major challenge in cancer treatment. This study aims to investigate whether intracellular drug delivery using hyaluronic acid (HA) functionalised pH-sensitive liposomes (HA-pSL) can circumvent gemcitabine resistance in pancrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09abaf95014ffe828366bec80fe3cba
https://pubmed.ncbi.nlm.nih.gov/31096017
https://pubmed.ncbi.nlm.nih.gov/31096017
Publikováno v:
Pharmaceutical Research. 35
To fabricate an acid-cleavable PEG polymer for the development of PEG-cleavable pH-sensitive liposomes (CL-pPSL), and to investigate their ability for endosomal escape and long circulation. PEG-benzaldehyde-hydrazone-cholesteryl hemisuccinate (PEGB-H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c125d2f3251ad3fecc8d820ce71704
https://doi.org/10.1007/s11095-018-2429-y
https://doi.org/10.1007/s11095-018-2429-y
Autor:
James R. Falconer, Hongtao Xu, Bruce C. Baguley, Manju Kanamala, Jianping Liu, Guangji Wang, Zimei Wu, Wenli Zhang, John Shaw
Publikováno v:
International journal of pharmaceutics. 505(1-2)
This paper describes a novel method to improve drug retention in liposomes for the poorly water-soluble (lipophilic) model drug asulacrine (ASL). ASL was loaded in the aqueous phase of liposomes and the effects of aging conditions and drug loading le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550a5f24b7aeb0f861ddf43719ff12b1
https://pubmed.ncbi.nlm.nih.gov/27021465
https://pubmed.ncbi.nlm.nih.gov/27021465
Publikováno v:
Biomaterials. 85
As the mainstay in the treatment of various cancers, chemotherapy plays a vital role, but still faces many challenges, such as poor tumour selectivity and multidrug resistance (MDR). Targeted drug delivery using nanotechnology has provided a new stra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d9e4e3044f626e0b5bb7aaac2cf84b
https://pubmed.ncbi.nlm.nih.gov/26871891
https://pubmed.ncbi.nlm.nih.gov/26871891