Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Manju Bansal"'
Autor:
Devesh Bhimsaria, José A. Rodríguez-Martínez, Jacqui L. Mendez-Johnson, Debostuti Ghoshdastidar, Ashwin Varadarajan, Manju Bansal, Danette L. Daniels, Parameswaran Ramanathan, Aseem Z. Ansari
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Human nuclear receptors (NRs) are a superfamily of ligand-responsive transcription factors that have central roles in cellular function. Their malfunction is linked to numerous diseases, and the ability to modulate their activity with synthe
Externí odkaz:
https://doaj.org/article/242e27d07a204f70a4df0ed003cf82dd
Autor:
Ashish Shelar, Manju Bansal
Publikováno v:
Data in Brief, Vol 9, Iss C, Pp 781-802 (2016)
The various structural variations observed in TM helices of membrane proteins have been deconstructed into 9 distinct types of helix perturbations. These perturbations are defined by the deviation of TM helices from the predominantly observed linear
Externí odkaz:
https://doaj.org/article/44b75cb507964956a29c3a20926a4da9
Autor:
Sanjukta Das, Manju Bansal
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0212678 (2019)
In higher eukaryotes, gene architecture and structural properties of promoters have emerged as significant factors influencing variation in number of transcripts (expression level) and specificity of gene expression in a tissue (expression breadth),
Externí odkaz:
https://doaj.org/article/3fc43688971f46a4be3879cfd95b67c2
Autor:
Manju Bansal, Narayanaswamy Srinivasan
Understanding the functions and properties of molecules in living systems requires a detailed knowledge of their three-dimensional structures and the conformational variability that allows them to adopt multiple functional forms. Interpreting biologi
Flexibility of flanking DNA is a key determinant of transcription factor affinity for the core motif
Autor:
Debostuti Ghoshdastidar, Manju Bansal
Publikováno v:
Biophysical Journal. 121:3987-4000
Selective gene regulation is mediated by recognition of specific DNA sequences by transcription factors (TFs). The extremely challenging task of searching out specific cognate DNA binding sites among several million putative sites within the eukaryot
Autor:
Swagata Halder, Manju Bansal
Publikováno v:
RSC Advances. 12:11853-11865
A large number of bacteria have been found to govern virulence and heat shock responses using temperature sensing RNAs known as RNA thermometers (RNATs). They repress translation initiation by base pairing to the Shine-Dalgarno (SD) sequence at low t
Autor:
Asmita Gupta, Manju Bansal
Publikováno v:
Briefings in Bioinformatics
RNA structures are widely distributed across all life forms. The global conformation of these structures is defined by a variety of constituent structural units such as helices, hairpin loops, kissing-loop motifs and pseudoknots, which often behave i
Autor:
Venkata Rajesh Yella, Devesh Bhimsaria, José A. Rodríguez-Martínez, Manju Bansal, Aseem Z. Ansari, Debostuti Ghoshdastidar
Publikováno v:
Nucleic Acids Research
Spatial and temporal expression of genes is essential for maintaining phenotype integrity. Transcription factors (TFs) modulate expression patterns by binding to specific DNA sequences in the genome. Along with the core binding motif, the flanking se
Autor:
Venkata Rajesh Yella, Manju Bansal
Publikováno v:
FEBS Open Bio
Eukaryotic genes can be broadly classified as TATA-containing and TATA-less based on the presence of TATA box in their promoters. Experiments on both classes of genes have revealed a disparity in the regulation of gene expression and cellular functio
Autor:
Manju Bansal, Sanjukta Das
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0212678 (2019)
PLoS ONE
PLoS ONE
In higher eukaryotes, gene architecture and structural properties of promoters have emerged as significant factors influencing variation in number of transcripts (expression level) and specificity of gene expression in a tissue (expression breadth),