Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Manjong Han"'
Autor:
Ling Yu, Lindsay A. Dawson, Mingquan Yan, Katherine Zimmel, Yu-Lieh Lin, Connor P. Dolan, Manjong Han, Ken Muneoka
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Mammalian joints have poor regenerative capacity following amputation. Here, the authors show that in mice, stimulation of the amputation wound with BMP2 and BMP9 stimulates regeneration of a synovial joint that includes bone, cartilage and a synovia
Externí odkaz:
https://doaj.org/article/49ab87b3687b4f1eb6f372b52b35bc94
Autor:
Yuanyuan Wu, Karen Wang, Adrine Karapetyan, Warnakulusuriya Akash Fernando, Jennifer Simkin, Manjong Han, Elizabeth L Rugg, Ken Muneoka
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54764 (2013)
A key factor that contributes to the regenerative ability of regeneration-competent animals such as the salamander is their use of innate positional cues that guide the regeneration process. The limbs of mammals has severe regenerative limitations, h
Externí odkaz:
https://doaj.org/article/79dfed8b448c44ed9b2eca47ebd1a345
Autor:
Lindsay A. Dawson, Katherine N. Zimmel, Manjong Han, Ling Yu, Connor P. Dolan, Yu-Lieh Lin, Ken Muneoka, Mingquan Yan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Nature Communications
Nature Communications
A major goal of regenerative medicine is to stimulate tissue regeneration after traumatic injury. We previously discovered that treating digit amputation wounds with BMP2 in neonatal mice stimulates endochondral ossification to regenerate the stump b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5dd883b10aaaaa58de34eddf011152b
http://link.springer.com/article/10.1038/s41467-018-08278-4
http://link.springer.com/article/10.1038/s41467-018-08278-4
Autor:
Connor P. Dolan, Manjong Han, Ling Yu, Ken Muneoka, Paula P. Schanes, Lindsay A. Dawson, Britta Petersen, Mingquan Yan, Maegan Pela, Luis Marrero
Publikováno v:
Regeneration
Regeneration of mammalian limbs is restricted to amputation of the distal digit tip, the terminal phalanx (P3). The adjacent skeletal element, the middle phalanx (P2), has emerged as a model system to investigate regenerative failure and as a site to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cadc15c5c4bfcf1ebc685c35c5a2470
https://doi.org/10.1002/reg2.81
https://doi.org/10.1002/reg2.81
Autor:
Warnakulasuriya Akash Fernando, Ken Muneoka, Shyam Sathyamoorthi, Manjong Han, Carrie A. Malcom, Eric Leininger, Ni Li, Jennifer Simkin
Publikováno v:
Developmental Biology. 350:301-310
Amputation of the distal region of the terminal phalanx of mice causes an initial wound healing response followed by blastema formation and the regeneration of the digit tip. Thus far, most regeneration studies have focused in embryonic or neonatal m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f74584ff974e4fc899cd78d8ebdd07
https://doi.org/10.1016/j.ydbio.2010.11.035
https://doi.org/10.1016/j.ydbio.2010.11.035
Publikováno v:
Developmental Biology. 315:125-135
The digit tips of children and rodents are known to regenerate following amputation. The skeletal structure that regenerates is the distal region of the terminal phalangeal bone that is associated with the nail organ. The terminal phalanx forms late
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90ad8b1206b70cc7589677c824804081
https://doi.org/10.1016/j.ydbio.2007.12.025
https://doi.org/10.1016/j.ydbio.2007.12.025
Autor:
Manjong Han, Won-Sun Kim
Publikováno v:
Korean Journal of Biological Sciences. 6:301-304
In our previous study, we have shown that Fgf‐8 is expressed in the basal layer of the apical epithelial cap (AEC) and in the underlying thin layer of mesenchymal tissue of the regenerating limbs of Mexican axolotl, Amby‐stoma mexicanum. Our pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b64212869b0a49d287d0ff98d38e1706
https://doi.org/10.1080/12265071.2002.9647667
https://doi.org/10.1080/12265071.2002.9647667
Autor:
Manjong Han, Ling Yu, Jennifer Simkin, Eric Leininger, Ken Muneoka, Paulina D. Ketcham, Mingquan Yan
Publikováno v:
Regeneration
The regenerating mouse digit tip is a unique model for investigating blastema formation and epimorphic regeneration in mammals. The blastema is characteristically avascular and we previously reported that blastema expression of a known anti‐angioge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f280494043f21bec9ddef4fe195625
https://pubmed.ncbi.nlm.nih.gov/27499862
https://pubmed.ncbi.nlm.nih.gov/27499862
Publikováno v:
Developmental Dynamics. 220:40-48
Fgf-8 is one of the key signaling molecules implicated in the initiation, outgrowth, and patterning of vertebrate limbs. However, it is not clear whether FGF-8 plays similar role in development and regeneration of urodele limbs. We isolated a Fgf-8 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::190cd21df91e5ee966f78ae10ecdc51c
https://doi.org/10.1002/1097-0177(2000)9999:9999<::aid-dvdy1085>3.0.co
https://doi.org/10.1002/1097-0177(2000)9999:9999<::aid-dvdy1085>3.0.co
Publikováno v:
Developmental biology. 382(1)
Previously we demonstrated that BMP signaling is required for endogenous digit tip regeneration, and that treatment with BMP-2 or -7 induces a regenerative response following amputation at regeneration-incompetent levels (Yu et al., 2010, 2012). Both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd2d66aeb5f278a7b2759667fb6b7e9
https://pubmed.ncbi.nlm.nih.gov/23916851
https://pubmed.ncbi.nlm.nih.gov/23916851