Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Manjiong Wang"'
Autor:
Xiao Li, Yue Yao, Luoyifan Zhou, Jin Yang, Xin Chen, Chao Zhang, Manjiong Wang, Jian Li, Baoli Li, Yixiang Xu
Publikováno v:
Acta Materia Medica, Vol 3, Iss 2, Pp 133-146 (2024)
Sodium-glucose cotransporter 2 inhibitors are a class of glucose-lowering drugs known for robust cardiovascular protective properties. However, the side effects induced by Sodium-glucose cotransporter 2 inhibition limit application in cardiovascular
Externí odkaz:
https://doaj.org/article/18350333aec54130bd4b7329785183ac
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Aconitum episcopale Leveille is an important medicinal plant from the genus Aconitum L. of Ranunculaceae family and has been used as conventional medicine in Bai, Yi, and other ethnic groups of China. According to the available data and Ethn
Externí odkaz:
https://doaj.org/article/1238cbd65c5542e1b8e8d99ebb01af75
Autor:
Manjiong Wang, Tongke Tang, Zhenghui Huang, Ruoxi Li, Dazheng Ling, Jin Zhu, Lubin Jiang, Jian Li, Xiaokang Li
Publikováno v:
Acta Materia Medica, Vol 1, Iss 2, Pp 212-223 (2022)
In our previous work, the clinical phase II HDAC inhibitor quisinostat was identified as a promising antimalarial agent through a drug repurposing strategy, but its safety was a matter of concern. Herein, further medicinal chemistry methods were used
Externí odkaz:
https://doaj.org/article/0df388c2a89a40598d6452da0d817a24
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Aconitum is an important medicinal group of the Ranunculaceae family and has been used as conventional medicine in Bai, Yi, and other ethnic groups of China. There are about 350 Aconitum species globally and about 170 species in China. It is challeng
Externí odkaz:
https://doaj.org/article/bd5218bfbb39435c8b7a942d1b36013d
Autor:
Zhenghui Huang, Ruoxi Li, Tongke Tang, Dazheng Ling, Manjiong Wang, Dandan Xu, Maoxin Sun, Lulu Zheng, Feng Zhu, Hui Min, Rachasak Boonhok, Yan Ding, Yuhao Wen, Yicong Chen, Xiaokang Li, Yuxi Chen, Taiping Liu, Jiping Han, Jun Miao, Qiang Fang, Yaming Cao, Yun Tang, Jie Cui, Wenyue Xu, Liwang Cui, Jin Zhu, Gary Wong, Jian Li, Lubin Jiang
Publikováno v:
Cell Discovery, Vol 6, Iss 1, Pp 1-15 (2020)
Abstract Although artemisinin combination therapies have succeeded in reducing the global burden of malaria, multidrug resistance of the deadliest malaria parasite, Plasmodium falciparum, is emerging worldwide. Innovative antimalarial drugs that kill
Externí odkaz:
https://doaj.org/article/50d2b3f4b49741b1a46be483ad866a7c
Autor:
Manjiong Wang, Tongke Tang, Ruoxi Li, Zhenghui Huang, Dazheng Ling, Lulu Zheng, Yan Ding, Taiping Liu, Wenyue Xu, Feng Zhu, Hui Min, Rachasak Boonhok, Fei Mao, Jin Zhu, Xiaokang Li, Lubin Jiang, Jian Li
Publikováno v:
Journal of Medicinal Chemistry. 65:4156-4181
Autor:
Zhenghui Huang, Dazheng Ling, Fei Mao, Xiaokang Li, Tang Tongke, Jian Li, Jin Zhu, Li Ruoxi, Lubin Jiang, Manjiong Wang
Publikováno v:
Chinese Chemical Letters. 32:1660-1664
Antimalarial chemotherapies endowed with effectiveness against drug-resistant parasites and good safety are urgently required in clinical. Our previous research revealed that clinical phase Ⅱ antitumor drug Quisinostat was a promising antimalarial
Autor:
Zhenghui Huang, Xiaokang Li, Hanwen Wei, Tang Tongke, Dazheng Ling, Fei Mao, Taiping Liu, Wenyue Xu, Lubin Jiang, Li Ruoxi, Manjiong Wang, Jin Zhu, Yan Ding, Jian Li
Publikováno v:
Journal of Medicinal Chemistry. 64:2254-2271
Previously, we identified the clinical anticancer drug candidate quisinostat as a novel and potent antimalarial lead compound. To further enhance the antimalarial effect and improve safety, 31 novel spirocyclic hydroxamic acid derivatives were synthe
Autor:
Hongguang Zhang, Hai-Yan Zhang, Manjiong Wang, Yun Tang, Linghao Hu, Fei Mao, Xiaokang Li, Xiaoyan Chen, Wei Wang, Fengxia Bao, Songda Yu, Yixiang Xu, Qinyuan Zhao, Xun Ding, Feng Hongxuan, Zengrui Wu, Jiajing Hu, Jian Li
Publikováno v:
Journal of Medicinal Chemistry. 63:1051-1067
Our previous study had identified ciclopirox (CPX) as a promising lead compound for treatment of ischemic stroke. To find better neuroprotective agents, a series of N-hydroxypyridone derivatives based on CPX were designed, synthesized, and evaluated
Autor:
Yixiang Xu, Conglong Xia, Jiaqi Liu, Lu Taotao, Bei Jiang, Jiqun Wang, Jian Li, Houwen Lin, Manjiong Wang, Donglei Shi, Xiaokang Li, Yunyuan Huang
Publikováno v:
Journal of chemical information and modeling. 62(21)
Combination drugs, characterized by high efficacy and few side effects, have received extensive attention from pharmaceutical companies and researchers for the treatment of complex diseases such as heart failure (HF). Traditional combination drug dis