Výsledky vyhledávání - "Manjima Dhar"

Phase 1 study of P-PSMA-101 CAR-T cells in patients with metastatic castration-resistant prostate cancer (mCRPC)

Autor: Susan F. Slovin, Tanya B. Dorff, Gerald Steven Falchook, Xiao X. Wei, Xin Gao, Rana R. McKay, David Yoonsuk Oh, Andreas Georg Wibmer, Matthew A. Spear, Joanne McCaigue, Devon J. Shedlock, Manjima Dhar, Julia Coronella, Christopher E. Martin, Majid Ghodussi, Ann Murphy, Eric M. Ostertag

Publikováno v: Journal of Clinical Oncology. 40:98-98

98 Background: P-PSMA-101 is an autologous CAR-T therapy targeting PSMA, with a high percentage of stem cell memory T cells (TSCM) associated with efficacy, safety, and bone homing (particularly relevant to prostate cancer). It is manufactured using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32c6609fcf7689bc849502f472887948
https://doi.org/10.1200/jco.2022.40.6_suppl.098

Zobrazit plný text záznamu

Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting

Autor: Jessica S. Martinez, Da Eun Park, Dino Di Carlo, Sireesha Kaanumale, Hiromi Miwa, Chris Puleo, David A. Hafler, John Frederick Graf, Manjima Dhar, Coleman Murray, Evelina Roxana Loghin, Khadir Raddassi, Edward Pao, William W. Kwok

Publikováno v: Lab on a chip, vol 18, iss 16

Immunotherapies (IT) require induction, expansion, and maintenance of specific changes to a patient's immune cell repertoire which yield a therapeutic benefit. Recently, mechanistic understanding of these changes at the cellular level has revealed th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0140cad648fee0bca86eadf388ea7d92
https://doi.org/10.1039/c8lc00518d

Zobrazit plný text záznamu

Functional profiling of circulating tumor cells with an integrated vortex capture and single-cell protease activity assay

Autor: Dino Di Carlo, Manjima Dhar, Steven M. Dubinett, Jeffrey Nam Lam, Matthew Rettig, Tonya C. Walser

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 40

Tumor cells are hypothesized to use proteolytic enzymes to facilitate invasion. Whether circulating tumor cells (CTCs) secrete these enzymes to aid metastasis is unknown. A quantitative and high-throughput approach to assay CTC secretion is needed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d358cc713dbdf81f50568457b7187d92
https://europepmc.org/articles/PMC6176626/

Zobrazit plný text záznamu

Evaluation of PD-L1 expression on vortex-isolated circulating tumor cells in metastatic lung cancer

Autor: Elodie Sollier Christen, Jonathan W. Goldman, Dino Di Carlo, James Che, David Elashoff, Rajan P. Kulkarni, Manjima Dhar, Jessica Wong, Tristan Grogan, Edward B. Garon, Melissa Matsumoto

Publikováno v: Scientific reports, vol 8, iss 1
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports

Metastatic non-small cell lung cancer (NSCLC) is a highly fatal and immunogenic malignancy. Although the immune system is known to recognize these tumor cells, one mechanism by which NSCLC can evade the immune system is via overexpression of programm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d05faceeef49574b7bf08cd0b0cac59
https://escholarship.org/uc/item/9pm068bt

Zobrazit plný text záznamu

Research highlights: manipulating cells inside and out

Autor: Dino Di Carlo, Manjima Dhar, Andy Tay, Ivan Pushkarsky

Publikováno v: Lab on a Chip. 15:2533-2537

We highlight recent work manipulating cells: from whole cells, to intracellular content, and even subcellular gradients in proteins. In the first manuscript, using interdigitated electrode arrays at a controlled tilt angle to a microchannel allows fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ccb44f556a942db49fba19b52e8dfb
https://doi.org/10.1039/c5lc90060c

Zobrazit plný text záznamu

Research highlights: microfluidic-enabled single-cell epigenetics

Autor: Reem Khojah, Dino Di Carlo, Andy Tay, Manjima Dhar

Publikováno v: Lab on a Chip. 15:4109-4113

Individual cells are the fundamental unit of life with diverse functions from metabolism to motility. In multicellular organisms, a single genome can give rise to tremendous variability across tissues at the single-cell level due to epigenetic differ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013ddb440c940bba2888e959f168e773
https://doi.org/10.1039/c5lc90101d

Zobrazit plný text záznamu

High-throughput physical phenotyping of cell differentiation

Autor: Jonathan Lin, Manjima Dhar, Lillian Peng, Saravanan Karumbayaram, Peter Tseng, Donghyuk Kim, Henry T. Tse, Dino Di Carlo

Publikováno v: Microsystems & nanoengineering, vol 3, iss 1

In this report, we present multiparameter deformability cytometry (m-DC), in which we explore a large set of parameters describing the physical phenotypes of pluripotent cells and their derivatives. m-DC utilizes microfluidic inertial focusing and hy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8879b3dc6f1c035ae7e36af6db4615
https://escholarship.org/uc/item/64p5v7wj

Zobrazit plný text záznamu

Label-free enumeration, collection and downstream cytological and cytogenetic analysis of circulating tumor cells

Autor: Elodie Sollier-Christen, Melissa Matsumoto, Edward B. Garon, Kyra Heirich, Corinne Renier, Rosita Montoya, Derek E. Go, Manjima Dhar, Melanie Triboulet, Rajan P. Kulkarni, Rachel Conrad, Dino Di Carlo, Edward Pao, James Che, Nagesh Rao, Stefanie S. Jeffrey, Jianyu Rao, Jonathan H. Goldman

Publikováno v: Scientific Reports

Circulating tumor cells (CTCs) have a great potential as indicators of metastatic disease that may help physicians improve cancer prognostication, treatment and patient outcomes. Heterogeneous marker expression as well as the complexity of current an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305d7d14bf8c611a3cc51fe8d7ea8aaa

Zobrazit plný text záznamu

Classification of large circulating tumor cells isolated with ultra-high throughput microfluidic Vortex technology

Autor: Jonathan W. Goldman, Elodie Sollier, James Che, Jianyu Rao, Shruti Sheth, Edward B. Garon, Stefanie S. Jeffrey, Corinne Renier, Manjima Dhar, Rajan P. Kulkarni, George W. Sledge, Dino Di Carlo, Victor Yu, Mark D. Pegram, Kyra Heirich, Melissa Matsumoto

Publikováno v: Oncotarget

Circulating tumor cells (CTCs) are emerging as rare but clinically significant non-invasive cellular biomarkers for cancer patient prognosis, treatment selection, and treatment monitoring. Current CTC isolation approaches, such as immunoaffinity, fil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb57b6ae1009cb7ebca5d9a65c64fcb0
https://pubmed.ncbi.nlm.nih.gov/26863573

Zobrazit plný text záznamu

Correction: Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting

Autor: Coleman Murray, Hiromi Miwa, Manjima Dhar, Da Eun Park, Edward Pao, Jessica Martinez, Sireesha Kaanumale, Evelina Loghin, John Graf, Khadir Raddassi, William W. Kwok, David Hafler, Chris Puleo, Dino Di Carlo

Publikováno v: Lab on a Chip. 18:3703-3703

Correction for ‘Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting’ by Coleman Murray et al., Lab Chip, 2018, 18, 2396–2409.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5f72014cc56b7326c3482efba2fa760
https://doi.org/10.1039/c8lc90095g

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání