Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Manjeet K Rao"'
Autor:
Shan Qi, Javier Mota, Siu-Hong Chan, Johanna Villarreal, Nan Dai, Shailee Arya, Robert A Hromas, Manjeet K Rao, Ivan R Corrêa Jr, Yogesh K Gupta
Publikováno v:
eLife, Vol 11 (2022)
Methyltransferase like-3 (METTL3) and METTL14 complex transfers a methyl group from S-adenosyl-L-methionine to N6 amino group of adenosine bases in RNA (m6A) and DNA (m6dA). Emerging evidence highlights a role of METTL3-METTL14 in the chromatin conte
Externí odkaz:
https://doaj.org/article/f4794168c2784b479a677f7a2e4a2a3c
Autor:
Manuel A. Riquelme, Xuewei Wang, Francisca M. Acosta, Jingruo Zhang, Jeffery Chavez, Sumin Gu, Peng Zhao, Wei Xiong, Ningyan Zhang, Guo Li, Saranya Srinivasan, Chaoyu Ma, Manjeet K. Rao, Lu-Zhe Sun, Nu Zhang, Zhiqiang An, Jean X. Jiang
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114377- (2024)
Summary: Bone tissue represents the most frequent site of cancer metastasis. We developed a hemichannel-activating antibody, Cx43-M2. Cx43-M2, directly targeting osteocytes in situ, activates osteocytic hemichannels and elevates extracellular ATP, th
Externí odkaz:
https://doaj.org/article/4756bc7168ea467aa3d390ca0185e247
Autor:
Subbarayalu Panneerdoss, Yao-Fu Chang, Kalyan C Buddavarapu, Hung-I Harry Chen, Gunapala Shetty, Huizhen Wang, Yidong Chen, T Rajendra Kumar, Manjeet K Rao
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41146 (2012)
Although decades of research have established that androgen is essential for spermatogenesis, androgen's mechanism of action remains elusive. This is in part because only a few androgen-responsive genes have been definitively identified in the testis
Externí odkaz:
https://doaj.org/article/a8f993d1df4646c597d0b4eba5682e7e
Autor:
J Saadi Imam, Jason R Plyler, Hima Bansal, Suresh Prajapati, Sanjay Bansal, Jennifer Rebeles, Hung-I Harry Chen, Yao-Fu Chang, Subbarayalu Panneerdoss, Behyar Zoghi, Kalyan C Buddavarapu, Russell Broaddus, Peter Hornsby, Gail Tomlinson, Jeffrey Dome, Ratna K Vadlamudi, Alexander Pertsemlidis, Yidong Chen, Manjeet K Rao
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52397 (2012)
Increasing evidence suggests that chromosomal regions containing microRNAs are functionally important in cancers. Here, we show that genomic loci encoding miR-204 are frequently lost in multiple cancers, including ovarian cancers, pediatric renal tum
Externí odkaz:
https://doaj.org/article/16d3ea8cfd0a404a8473f4680e23743b
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e28039 (2011)
Though roles of β-catenin signaling during testis development have been well established, relatively little is known about its role in postnatal testicular physiology. Even less is known about its role in post-meiotic germ cell development and diffe
Externí odkaz:
https://doaj.org/article/887b7fd3027a4f4d96f25bf193385f4a
Publikováno v:
Biomedicines, Vol 12, Iss 9, p 1979 (2024)
This review explores the challenges and emerging trends in pancreatic cancer therapy. In particular, we focus on the tumor microenvironment and the potential of immunotherapy for pancreatic cancer. Pancreatic ductal adenocarcinoma, characterized by i
Externí odkaz:
https://doaj.org/article/a58cbcfb008b488f884e8cb0db545fca
Autor:
Subapriya Rajamanickam, Jun Hyoung Park, Panneerdoss Subbarayalu, Santosh Timilsina, Kaitlyn Bates, Pooja Yadav, Saif S. R. Nirzhor, Vijay Eedunuri, Tabrez A. Mohammad, Kwang Hwa Jung, Benjamin Onyeagucha, Nourhan Abdelfattah, Raymond Benevides, Grace Lee, Yidong Chen, Ratna Vadlamudi, Andrew Brenner, Virginia Kaklamani, Ismail Jatoi, John Kuhn, Robert Hromas, Yogesh K. Gupta, Benny A. Kaipparettu, Jack L. Arbiser, Manjeet K. Rao
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
A report of the small molecule Carbazole Blue demonstrates inhibition of breast cancer growth and metastasis without adverse effects on normal tissue.
Externí odkaz:
https://doaj.org/article/7a4cae1b109747c5bf6ef01173eb2df8
Autor:
Mengxing Li, Suryavathi Viswanadhapalli, Bindu Santhamma, Uday P. Pratap, Yiliao Luo, Junhao Liu, Kristin A. Altwegg, Weiwei Tang, Zexuan Liu, Xiaonan Li, Behnam Ebrahimi, Hui Yan, Yi Zou, Swapna Konda, Gangadhara R. Sareddy, Zhenming Xu, Yidong Chen, Manjeet K. Rao, Andrew J. Brenner, Virginia G. Kaklamani, Rajeshwar R. Tekmal, Gulzar Ahmed, Ganesh V. Raj, Klaus J. Nickisch, Hareesh B. Nair, Ratna K. Vadlamudi
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Li, Viswanadhapalli et al utilized multiple in vitro, ex vivo and in vivo models of TNBC to investigate LIFR inhibition. The authors reported that HDAC inhibition in TNBC cells led to an increase of LIFR expression and over activation of the downstre
Externí odkaz:
https://doaj.org/article/8b39ff553a7a47e7a5a926087847574b
Autor:
Panneerdoss Subbarayalu, Pooja Yadav, Santosh Timilsina, Daisy Medina, Kunal Baxi, Robert Hromas, Ratna K. Vadlamudi, Yidong Chen, Patrick Sung, Manjeet K. Rao
Publikováno v:
Cells, Vol 12, Iss 9, p 1283 (2023)
Eukaryotic cells maintain cellular fitness by employing well-coordinated and evolutionarily conserved processes that negotiate stress induced by internal or external environments. These processes include the unfolded protein response, autophagy, endo
Externí odkaz:
https://doaj.org/article/6c4152b2a7b1458eac61c892efb6575e
Autor:
Kristin A. Altwegg, Uday P. Pratap, Zexuan Liu, Junhao Liu, John R. Sanchez, Xue Yang, Behnam Ebrahimi, Durga Meenakshi Panneerdoss, Xiaonan Li, Gangadhara R. Sareddy, Suryavathi Viswanadhapalli, Manjeet K. Rao, Ratna K. Vadlamudi
Publikováno v:
Breast Cancer Research and Treatment. 200:151-162
Purpose Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. Oncogenic PELP1 is frequently overexpressed in TNBC, and it has been demonstrated that PELP1 signaling is essential for TNBC progression. The therapeutic ut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::471de0f99b69c5d30e715ee10ca18fff
https://doi.org/10.1007/s10549-023-06958-4
https://doi.org/10.1007/s10549-023-06958-4