Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Manjeet K Rao"'
Autor:
Manuel A. Riquelme, Xuewei Wang, Francisca M. Acosta, Jingruo Zhang, Jeffery Chavez, Sumin Gu, Peng Zhao, Wei Xiong, Ningyan Zhang, Guo Li, Saranya Srinivasan, Chaoyu Ma, Manjeet K. Rao, Lu-Zhe Sun, Nu Zhang, Zhiqiang An, Jean X. Jiang
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114377- (2024)
Summary: Bone tissue represents the most frequent site of cancer metastasis. We developed a hemichannel-activating antibody, Cx43-M2. Cx43-M2, directly targeting osteocytes in situ, activates osteocytic hemichannels and elevates extracellular ATP, th
Externí odkaz:
https://doaj.org/article/4756bc7168ea467aa3d390ca0185e247
Publikováno v:
Biomedicines, Vol 12, Iss 9, p 1979 (2024)
This review explores the challenges and emerging trends in pancreatic cancer therapy. In particular, we focus on the tumor microenvironment and the potential of immunotherapy for pancreatic cancer. Pancreatic ductal adenocarcinoma, characterized by i
Externí odkaz:
https://doaj.org/article/a58cbcfb008b488f884e8cb0db545fca
Autor:
Subapriya Rajamanickam, Jun Hyoung Park, Panneerdoss Subbarayalu, Santosh Timilsina, Kaitlyn Bates, Pooja Yadav, Saif S. R. Nirzhor, Vijay Eedunuri, Tabrez A. Mohammad, Kwang Hwa Jung, Benjamin Onyeagucha, Nourhan Abdelfattah, Raymond Benevides, Grace Lee, Yidong Chen, Ratna Vadlamudi, Andrew Brenner, Virginia Kaklamani, Ismail Jatoi, John Kuhn, Robert Hromas, Yogesh K. Gupta, Benny A. Kaipparettu, Jack L. Arbiser, Manjeet K. Rao
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
A report of the small molecule Carbazole Blue demonstrates inhibition of breast cancer growth and metastasis without adverse effects on normal tissue.
Externí odkaz:
https://doaj.org/article/7a4cae1b109747c5bf6ef01173eb2df8
Autor:
Zexuan Liu, Junhao Liu, Behnam Ebrahimi, Uday P. Pratap, Yi He, Kristin A. Altwegg, Weiwei Tang, Xiaonan Li, Zhao Lai, Yidong Chen, Liangfang Shen, Gangadhara R. Sareddy, Suryavathi Viswanadhapalli, Rajeshwar R. Tekmal, Manjeet K. Rao, Ratna K. Vadlamudi
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-18 (2022)
Abstract Background Methyltransferase SETDB1 is highly expressed in breast cancer (BC), however, the mechanisms by which SETDB1 promotes BC progression to endocrine therapy resistance remains elusive. In this study, we examined the mechanisms by whic
Externí odkaz:
https://doaj.org/article/9e4da8bdd334483492d30abd1b8a15f8
Autor:
Mengxing Li, Suryavathi Viswanadhapalli, Bindu Santhamma, Uday P. Pratap, Yiliao Luo, Junhao Liu, Kristin A. Altwegg, Weiwei Tang, Zexuan Liu, Xiaonan Li, Behnam Ebrahimi, Hui Yan, Yi Zou, Swapna Konda, Gangadhara R. Sareddy, Zhenming Xu, Yidong Chen, Manjeet K. Rao, Andrew J. Brenner, Virginia G. Kaklamani, Rajeshwar R. Tekmal, Gulzar Ahmed, Ganesh V. Raj, Klaus J. Nickisch, Hareesh B. Nair, Ratna K. Vadlamudi
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Li, Viswanadhapalli et al utilized multiple in vitro, ex vivo and in vivo models of TNBC to investigate LIFR inhibition. The authors reported that HDAC inhibition in TNBC cells led to an increase of LIFR expression and over activation of the downstre
Externí odkaz:
https://doaj.org/article/8b39ff553a7a47e7a5a926087847574b
Autor:
Panneerdoss Subbarayalu, Pooja Yadav, Santosh Timilsina, Daisy Medina, Kunal Baxi, Robert Hromas, Ratna K. Vadlamudi, Yidong Chen, Patrick Sung, Manjeet K. Rao
Publikováno v:
Cells, Vol 12, Iss 9, p 1283 (2023)
Eukaryotic cells maintain cellular fitness by employing well-coordinated and evolutionarily conserved processes that negotiate stress induced by internal or external environments. These processes include the unfolded protein response, autophagy, endo
Externí odkaz:
https://doaj.org/article/6c4152b2a7b1458eac61c892efb6575e
Autor:
Shan Qi, Javier Mota, Siu-Hong Chan, Johanna Villarreal, Nan Dai, Shailee Arya, Robert A Hromas, Manjeet K Rao, Ivan R Corrêa Jr, Yogesh K Gupta
Publikováno v:
eLife, Vol 11 (2022)
Methyltransferase like-3 (METTL3) and METTL14 complex transfers a methyl group from S-adenosyl-L-methionine to N6 amino group of adenosine bases in RNA (m6A) and DNA (m6dA). Emerging evidence highlights a role of METTL3-METTL14 in the chromatin conte
Externí odkaz:
https://doaj.org/article/f4794168c2784b479a677f7a2e4a2a3c
Autor:
Prabhakar Pitta Venkata, Arhan D. Rao, Santosh Timilsina, Deepika Singh, Ratna K. Vadlamudi, Virginia Kaklamani, Manjeet K. Rao
Publikováno v:
Cancer Research. 83:P3-07
Anti-depressant Amitriptyline Augments the Efficacy of Tamoxifen in ER positive breast cancer Pitta Venkata Prabhakar1, Arhan D Rao1, Timilsina Santosh1, Deepika Singh1, Ratna Vadlamudi1,2, Virginia Kaklamani3, Manjeet Rao1,2. 1Greehey Children’s C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::237deb698b89398e48d410d93b3a8f0f
https://doi.org/10.1158/1538-7445.sabcs22-p3-07-19
https://doi.org/10.1158/1538-7445.sabcs22-p3-07-19
Autor:
Kristin A. Altwegg, Uday P. Pratap, Zexuan Liu, Junhao Liu, John R. Sanchez, Xue Yang, Behnam Ebrahimi, Durga Meenakshi Panneerdoss, Xiaonan Li, Gangadhara R. Sareddy, Suryavathi Viswanadhapalli, Manjeet K. Rao, Ratna K. Vadlamudi
Publikováno v:
Breast Cancer Research and Treatment. 200:151-162
Purpose Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. Oncogenic PELP1 is frequently overexpressed in TNBC, and it has been demonstrated that PELP1 signaling is essential for TNBC progression. The therapeutic ut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::471de0f99b69c5d30e715ee10ca18fff
https://doi.org/10.1007/s10549-023-06958-4
https://doi.org/10.1007/s10549-023-06958-4
Autor:
Nourhan Abdelfattah, Subapriya Rajamanickam, Subbarayalu Panneerdoss, Santosh Timilsina, Pooja Yadav, Benjamin C. Onyeagucha, Michael Garcia, Ratna Vadlamudi, Yidong Chen, Andrew Brenner, Peter Houghton, Manjeet K. Rao
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
The radiation and chemotherapy used for treating medulloblastoma patients cause debilitating side effects. Here, the authors show that miR-584 acts as a therapeutic adjuvant as it sensitizes medulloblastoma to radiation and chemotherapy by targeting
Externí odkaz:
https://doaj.org/article/7e6b817f247d44dd9e1ce5001fd43f4d