Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Manja Kubeil"'
Autor:
Liliana R. Loureiro, Lydia Hoffmann, Christin Neuber, Luise Rupp, Claudia Arndt, Alexandra Kegler, Manja Kubeil, Christoph E. Hagemeyer, Holger Stephan, Marc Schmitz, Anja Feldmann, Michael Bachmann
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-17 (2023)
Abstract Background Chimeric antigen receptor (CAR) T-cells are a promising approach in cancer immunotherapy, particularly for treating hematologic malignancies. Yet, their effectiveness is limited when tackling solid tumors, where immune cell infilt
Externí odkaz:
https://doaj.org/article/40cdac5b7b9a489091bc53905b399ab5
Autor:
Haidy A. Saleh, Nicola Mitwasi, Martin Ullrich, Manja Kubeil, Magali Toussaint, Winnie Deuther-Conrad, Christin Neuber, Claudia Arndt, Liliana R. Loureiro, Alexandra Kegler, Karla Elizabeth González Soto, Birgit Belter, Claudia Rössig, Jens Pietzsch, Marcus Frenz, Michael Bachmann, Anja Feldmann
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Glioblastoma (GBM) is still an incurable tumor that is associated with high recurrence rate and poor survival despite the current treatment regimes. With the urgent need for novel therapeutic strategies, immunotherapies, especially chimeric antigen r
Externí odkaz:
https://doaj.org/article/869c24c8ece440448383f3d31672b966
Autor:
Manja Kubeil, Irma Ivette Santana Martínez, Michael Bachmann, Klaus Kopka, Kellie L. Tuck, Holger Stephan
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 432 (2022)
Molecular imaging offers the possibility to investigate biological and biochemical processes non-invasively and to obtain information on both anatomy and dysfunctions. Based on the data obtained, a fundamental understanding of various disease process
Externí odkaz:
https://doaj.org/article/ac96f5cb53204ce0a7c9cef44a2ff19a
Autor:
Ralf Bergmann, Manja Kubeil, Kristof Zarschler, Sandeep Chhabra, Rajeev B. Tajhya, Christine Beeton, Michael W. Pennington, Michael Bachmann, Raymond S. Norton, Holger Stephan
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract The peptide HsTX1[R14A] is a potent and selective blocker of the voltage-gated potassium channel Kv1.3, which is a highly promising target for the treatment of autoimmune diseases and other conditions. In order to assess the biodistribution
Externí odkaz:
https://doaj.org/article/df49b90ff84b43d9acf32897f9f258e4
Autor:
Patrick Cieslik, Manja Kubeil, Kristof Zarschler, Martin Ullrich, Florian Brandt, Karl Anger, Hubert Wadepohl, Klaus Kopka, Michael Bachmann, Jens Pietzsch, Holger Stephan, Peter Comba
Publikováno v:
Journal of the American Chemical Society 144(2022)47, 21555-21567
We report a nonadentate bispidine (3,7-diazabicyclo[3.3.1]nonane) that unveils the potential to bind theranostically relevant radionuclides, including indium-111, lutetium-177 and actinium-225 at mild labeling conditions. This radiopharmaceutical can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6abeb49cfe69f6fd27607451b901b800
https://pubmed.ncbi.nlm.nih.gov/36382991
https://pubmed.ncbi.nlm.nih.gov/36382991
Autor:
Hua Yang, Chris Orvig, Luke Wharton, Manja Kubeil, Xiaozhu Wang, Holger Stephan, Lily Southcott, Kristof Zarschler, María de Guadalupe Jaraquemada-Peláez, Neha Choudhary, Brian O. Patrick
Publikováno v:
Inorganic Chemistry. 60:12186-12196
A new versatile chelating ligand for intermediate size and softness radiometals [64Cu]Cu2+ and [111In]In3+, H2pyhox, was synthesized by introducing pyridine as a new donor moiety to complement 8-hydroxyquinoline on an ethylenediamine backbone. The co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0722e576664cd29132a5129fdb6bde8
https://doi.org/10.1021/acs.inorgchem.1c01412
https://doi.org/10.1021/acs.inorgchem.1c01412
Autor:
Lily Southcott, Valery Radchenko, Hua Yang, Manja Kubeil, Xiaozhu Wang, María de Guadalupe Jaraquemada-Peláez, Luke Wharton, Holger Stephan, Chris Orvig
Publikováno v:
Dalton Transactions. 50:3874-3886
Advances in nuclear medicine depend on chelating ligands that form highly stable and kinetically inert complexes with relevant radiometal ions for use in diagnosis or therapy. A new potentially decadentate ligand, H5decaox, was synthesised to incorpo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aaaab1c3eb95c85b7b1bc70a7a101fcb
https://doi.org/10.1039/d0dt04230g
https://doi.org/10.1039/d0dt04230g
Autor:
Manja Kubeil, Valery Radchenko, Neha Choudhary, Jonathan W. Engle, Holger Stephan, María de Guadalupe Jaraquemada-Peláez, Kendall E. Barrett, Chris Orvig
Publikováno v:
RSC Advances. 11:15663-15674
The bisoxine hexadentate chelating ligand, H3glyox was investigated for its affinity for Mn2+, Cu2+ and Lu3+ ions; all three metal ions are relevant with applications in nuclear medicine and medicinal inorganic chemistry. The aqueous coordination che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fb10bc4eac476f2e497fbdb52ebd8d0
https://doi.org/10.1039/d1ra01793d
https://doi.org/10.1039/d1ra01793d
Autor:
Adrian Wünsche, Kristof Zarschler, Birgit Belter, Stephan Holger, Klaus Kopka, Jens Pietzsch, Manja Kubeil
Publikováno v:
Nuclear Medicine and Biology. :S74-S75
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::434e726a6f276d7f675e6485d5441986
https://doi.org/10.1016/s0969-8051(22)02239-9
https://doi.org/10.1016/s0969-8051(22)02239-9
Autor:
Manja Kubeil, Chris Orvig, Xiaozhu Wang, Hannah K Wagner, Holger Stephan, Thomas I. Kostelnik, Lily Southcott, María de Guadalupe Jaraquemada-Peláez
Publikováno v:
Inorganic Chemistry. 59:7238-7251
A phosphinate-bearing picolinic acid-based chelating ligand (H6dappa) was synthesized and characterized to assess its potential as a bifunctional chelator (BFC) for inorganic radiopharmaceuticals. Nuclear magnetic resonance (NMR) spectroscopy was emp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90df8d146bf41be4e2a0b7187c23aa0b
https://doi.org/10.1021/acs.inorgchem.0c00671
https://doi.org/10.1021/acs.inorgchem.0c00671