Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Manja Friese-Hamim"'
Autor:
Wenyuan Xiong, Manja Friese‐Hamim, Andreas Johne, Christopher Stroh, Manfred Klevesath, Gerald S. Falchook, David S. Hong, Pascal Girard, Samer El Bawab
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 5, Pp 428-440 (2021)
Abstract Tepotinib is a highly selective and potent MET inhibitor in development for the treatment of patients with solid tumors. Given the favorable tolerability and safety profiles up to the maximum tested dose in the first‐in‐human (FIH) trial
Externí odkaz:
https://doaj.org/article/336092d3d9d74e2798fde9141c4ad366
Autor:
Michaela Medová, Thomas E. Carey, Yitzhak Zimmer, Daniel M. Aebersold, Tess M. Brodie, Mélanie Buchwalder, Matthias S. Dettmer, Marco D. Caversaccio, Aurélie Quintin, Beat Bojaxhiu, Christopher Stroh, Claudia Wilm, Manja Friese-Hamim, Olgun Elicin, Matúš Medo, Roland Giger, Paola Francica, Lluís Nisa
Radiotherapy (RT) along with surgery is the mainstay of treatment in head and neck squamous cell carcinoma (HNSCC). Radioresistance represents a major source of treatment failure, underlining the urgent necessity to explore and implement effective ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18d7f4b4cc91c10447085adfc7c3f2a0
https://doi.org/10.1158/1535-7163.c.6538632.v1
https://doi.org/10.1158/1535-7163.c.6538632.v1
Autor:
Michaela Medová, Thomas E. Carey, Yitzhak Zimmer, Daniel M. Aebersold, Tess M. Brodie, Mélanie Buchwalder, Matthias S. Dettmer, Marco D. Caversaccio, Aurélie Quintin, Beat Bojaxhiu, Christopher Stroh, Claudia Wilm, Manja Friese-Hamim, Olgun Elicin, Matúš Medo, Roland Giger, Paola Francica, Lluís Nisa
Supplementary Table 1 shows HNSCC patients' characteristics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28558227c47ea1cda3865b83c04df27b
https://doi.org/10.1158/1535-7163.22507239.v1
https://doi.org/10.1158/1535-7163.22507239.v1
Autor:
Michaela Medová, Thomas E. Carey, Yitzhak Zimmer, Daniel M. Aebersold, Tess M. Brodie, Mélanie Buchwalder, Matthias S. Dettmer, Marco D. Caversaccio, Aurélie Quintin, Beat Bojaxhiu, Christopher Stroh, Claudia Wilm, Manja Friese-Hamim, Olgun Elicin, Matúš Medo, Roland Giger, Paola Francica, Lluís Nisa
Supplementary figure 1 provides data concerning establishment of organotypic tissue cultures from freshly-resected HNSCC specimen Supplementary figure 2 shows analyses of MET expression and mutational status in a HNSCC cohort Supplementary figure 3 s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54cfa883d2b3f97b4576dfb0167cf151
https://doi.org/10.1158/1535-7163.22507233.v1
https://doi.org/10.1158/1535-7163.22507233.v1
Autor:
Michaela Medová, Thomas E. Carey, Yitzhak Zimmer, Daniel M. Aebersold, Tess M. Brodie, Mélanie Buchwalder, Matthias S. Dettmer, Marco D. Caversaccio, Aurélie Quintin, Beat Bojaxhiu, Christopher Stroh, Claudia Wilm, Manja Friese-Hamim, Olgun Elicin, Matúš Medo, Roland Giger, Paola Francica, Lluís Nisa
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b77ed32fd3fbb4e447b636c9b7adac57
https://doi.org/10.1158/1535-7163.22507242.v1
https://doi.org/10.1158/1535-7163.22507242.v1
Autor:
Michaela Medová, Thomas E. Carey, Yitzhak Zimmer, Daniel M. Aebersold, Tess M. Brodie, Mélanie Buchwalder, Matthias S. Dettmer, Marco D. Caversaccio, Aurélie Quintin, Beat Bojaxhiu, Christopher Stroh, Claudia Wilm, Manja Friese-Hamim, Olgun Elicin, Matúš Medo, Roland Giger, Paola Francica, Lluís Nisa
Supplementary Table 2 provides odds ratio per protein (CyTOF measurements)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc22fd03491f2a54987d58c474eddb4
https://doi.org/10.1158/1535-7163.22507236
https://doi.org/10.1158/1535-7163.22507236
Autor:
Andree Blaukat, Oliver Schadt, Frank Stieber, Ulrich Pehl, Frank Jaehrling, Dieter Dorsch, Michael Meyring, Ulrich Grädler, Claus Fittschen, Claudia Wilm, Christine Knuehl, Manja Friese-Hamim, Bettina Faden, Friedhelm Bladt
PDF file - 75K, High responsiveness of c-Met-addicted cell lines to treatment with EMD 1214063 and EMD 1204831. The impact of EMD 1214063 and EMD 1204831 on tumor cell viability (IC50) was tested in vitro, using a panel of tumor cell lines specifical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19326c3f35618f2086e6990b85bcee69
https://doi.org/10.1158/1078-0432.22451541
https://doi.org/10.1158/1078-0432.22451541
Autor:
Andree Blaukat, Oliver Schadt, Frank Stieber, Ulrich Pehl, Frank Jaehrling, Dieter Dorsch, Michael Meyring, Ulrich Grädler, Claus Fittschen, Claudia Wilm, Christine Knuehl, Manja Friese-Hamim, Bettina Faden, Friedhelm Bladt
PDF file - 184K, EMD 1214063 and EMD 1204831 display anti-tumor activity in HGF-dependent and HGF-independent xenograft tumor models. Mice bearing subcutaneous tumors derived from the human gastric Hs746T cell line (A and B) or the glioblastoma U87MG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03592926e46a69b8ef9743e7c67128ac
https://doi.org/10.1158/1078-0432.22451550
https://doi.org/10.1158/1078-0432.22451550
Autor:
Andree Blaukat, Oliver Schadt, Frank Stieber, Ulrich Pehl, Frank Jaehrling, Dieter Dorsch, Michael Meyring, Ulrich Grädler, Claus Fittschen, Claudia Wilm, Christine Knuehl, Manja Friese-Hamim, Bettina Faden, Friedhelm Bladt
PDF file - 255K, Effective inhibition of in vitro tumor cell migration by EMD 1214063 and EMD 1204831. A classical "wound healing" test was performed to assess the impact of EMD 1214063 (A) and EMD 1204831 (B) on tumor cell migration. In brief, H441
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f477947e78a52a3426f6e533a5fb5e63
https://doi.org/10.1158/1078-0432.22451568
https://doi.org/10.1158/1078-0432.22451568
Purpose: To explore in a panel of patient-derived xenograft models of human non–small cell lung cancer (NSCLC) whether high EGFR expression, was associated with cetuximab activity.Experimental Design: NSCLC patient-derived xenograft models (n = 45)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b512d2709a602523a20a398f27cfe29
https://doi.org/10.1158/1078-0432.c.6522747.v1
https://doi.org/10.1158/1078-0432.c.6522747.v1