Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Manja, Wobus"'
Autor:
Liliia Ibneeva, Sumeet Pal Singh, Anupam Sinha, Sema Elif Eski, Rebekka Wehner, Luise Rupp, Iryna Kovtun, Juan Alberto Pérez-Valencia, Alexander Gerbaulet, Susanne Reinhardt, Manja Wobus, Malte von Bonin, Jaime Sancho, Frances Lund, Andreas Dahl, Marc Schmitz, Martin Bornhäuser, Triantafyllos Chavakis, Ben Wielockx, Tatyana Grinenko
Publikováno v:
PLoS Biology, Vol 22, Iss 2, p e3002517 (2024)
A subpopulation of deeply quiescent, so-called dormant hematopoietic stem cells (dHSCs) resides at the top of the hematopoietic hierarchy and serves as a reserve pool for HSCs. The state of dormancy protects the HSC pool from exhaustion throughout li
Externí odkaz:
https://doaj.org/article/6e6a2cac4f004ac1b93ef75582908b4f
Autor:
Ilker A. Deniz, Jana Karbanová, Manja Wobus, Martin Bornhäuser, Pauline Wimberger, Jan Dominik Kuhlmann, Denis Corbeil
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background Multipotent mesenchymal stromal cells (MSCs) are precursors of various cell types. Through soluble factors, direct cell–cell interactions and other intercellular communication mechanisms such as extracellular vesicles and tunnel
Externí odkaz:
https://doaj.org/article/f4cf04abcea143989770755cf86a27bb
Autor:
Amanpreet Bains, Julia Schulz, Valentina Magno, Toni Radanovic, Sandra Rother, Michael Cross, Xie Xiaofan, Carsten Werner, Manja Wobus, Uwe Platzbecker
Publikováno v:
HemaSphere, Vol 7, p e6256097 (2023)
Externí odkaz:
https://doaj.org/article/0c31cb3d9ff84ccb84bd56908ecd7f32
Autor:
Manja Wobus, Martin Bornhäuser
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/e824464e26b24ef6b56799c5aed9e373
Autor:
Maik Herbig, Angela Jacobi, Manja Wobus, Heike Weidner, Anna Mies, Martin Kräter, Oliver Otto, Christian Thiede, Marie‑Theresa Weickert, Katharina S. Götze, Martina Rauner, Lorenz C. Hofbauer, Martin Bornhäuser, Jochen Guck, Marius Ader, Uwe Platzbecker, Ekaterina Balaian
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Diagnosis of myelodysplastic syndrome (MDS) mainly relies on a manual assessment of the peripheral blood and bone marrow cell morphology. The WHO guidelines suggest a visual screening of 200 to 500 cells which inevitably turns the assessor b
Externí odkaz:
https://doaj.org/article/47750a67f89b4072ae8b903f4aa9907e
Autor:
Friedrich Stölzel, Sarah E. Fordham, Devi Nandana, Wei-Yu Lin, Helen Blair, Claire Elstob, Hayden L. Bell, Brigitte Mohr, Leo Ruhnke, Desiree Kunadt, Claudia Dill, Daniel Allsop, Rachel Piddock, Emmanouela-Niki Soura, Catherine Park, Mohd Fadly, Thahira Rahman, Abrar Alharbi, Manja Wobus, Heidi Altmann, Christoph Röllig, Lisa Wagenführ, Gail L. Jones, Tobias Menne, Graham H. Jackson, Helen J. Marr, Jude Fitzgibbon, Kenan Onel, Manja Meggendorfer, Amber Robinson, Zuzanna Bziuk, Emily Bowes, Olaf Heidenreich, Torsten Haferlach, Sara Villar, Beñat Ariceta, Rosa Ayala Diaz, Steven J. Altschuler, Lani F. Wu, Felipe Prosper, Pau Montesinos, Joaquin Martinez-Lopez, Martin Bornhäuser, James M. Allan
Publikováno v:
JCI Insight, Vol 8, Iss 2 (2023)
Precision medicine can significantly improve outcomes for patients with cancer, but implementation requires comprehensive characterization of tumor cells to identify therapeutically exploitable vulnerabilities. Here, we describe somatic biallelic TET
Externí odkaz:
https://doaj.org/article/099cf4b757194708b07592874d0436b2
Autor:
Thomas Krüger, Rebekka Wehner, Maik Herbig, Martin Kräter, Michael Kramer, Jan Moritz Middeke, Friedrich Stölzel, Catrin List, Katharina Egger-Heidrich, Raphael Teipel, Uta Oelschlägel, Martin Wermke, Helena Jambor, Manja Wobus, Johannes Schetelig, Korinna Jöhrens, Torsten Tonn, Julien Subburayalu, Marc Schmitz, Martin Bornhauser, Malte von Bonin
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Functional impairment of the bone marrow (BM) niche has been suggested as a major reason for prolonged cytopenia and secondary graft failure after allogeneic hematopoietic cell transplantation (alloHCT). Because mesenchymal stromal cells (MSCs) serve
Externí odkaz:
https://doaj.org/article/992e9a44ebef4b9ba25024701532295d
Autor:
Amanpreet Kaur Bains, Lena Behrens Wu, Jennifer Rivière, Sandra Rother, Valentina Magno, Jens Friedrichs, Carsten Werner, Martin Bornhäuser, Katharina S. Götze, Michael Cross, Uwe Platzbecker, Manja Wobus
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Myelodysplastic syndromes (MDS) comprise a heterogeneous group of hematologic malignancies characterized by clonal hematopoiesis, one or more cytopenias such as anemia, neutropenia, or thrombocytopenia, abnormal cellular maturation, and a high risk o
Externí odkaz:
https://doaj.org/article/b83778c1857a4036970f1326a1e31357
Autor:
Pascal Fichtel, Malte von Bonin, Robert Kuhnert, Kristin Möbus, Martin Bornhäuser, Manja Wobus
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Aging of the hematopoietic system is characterized by an expansion of hematopoietic stem and progenitor cells (HSPCs) with reduced capacity for engraftment, self-renewal, and lymphoid differentiation, resulting in myeloid-biased hematopoiesis. This p
Externí odkaz:
https://doaj.org/article/e6a155e6f35f4c3492034ce270812d2b
Autor:
Luise Müller, Antje Tunger, Manja Wobus, Malte von Bonin, Russell Towers, Martin Bornhäuser, Francesco Dazzi, Rebekka Wehner, Marc Schmitz
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Mesenchymal stromal cells (MSCs) are characterized by an extraordinary capacity to modulate the phenotype and functional properties of various immune cells that play an essential role in the pathogenesis of inflammatory disorders. Thus, MSCs efficien
Externí odkaz:
https://doaj.org/article/1e1d2d3802e6401c9a6a73cd97374963