Supplementation with Bifidobacterium longum subspecies infantis EVC001 for mitigation of type 1 diabetes autoimmunity: the GPPAD-SINT1A randomised controlled trial protocol

Autor: Matthew D Snape, Melanie Gündert, Anette-Gabriele Ziegler, Peter Achenbach, Reinhard Berner, Kristina Casteels, Thomas Danne, Joerg Hasford, Olga Kordonouri, Karin Lange, Helena Elding Larsson, Markus Lundgren, Agnieszka Szypowska, John A Todd, Ezio Bonifacio, Nicole Zubizarreta, Christiane Winkler, Åke Lernmark, Daniel Agardh, Cigdem Gezginci, Claudia Ramminger, Marlon Scholz, Katharina Warncke, Carin Andrén Aronsson, Rasmus Bennet, Lina Fransson, Zeliha Mestan, Caroline Nilsson, Anita Ramelius, Carina Törn, Sarah Hogg, Catherine Owen, Lidia Groele, Florian Haupt, Claudia Matzke, Robin Assfalg, Matthew Snape, Felix Reschke, Marcin L Pekalski, Andreas Weiss, Andrew Johnston, Manja Jolink, Loredana Marcovecchio, Mariusz Ołtarzewski, Stefanie Arnolds, Annika Kölln, Markus Pfirrmann, Corinna Barz, Karina Blasius, Nadine Friedl, Adriano Gomez-Bantel, Martin Heigermoser, Bianca Höfelschweiger, Nadine Klein, Ramona Lickert, Rebecca Niewöhner, Katharina Schütte-Borkovec, Mira Taulien, Lara Vogel, Franziska Voß, José Maria Zapardiel Gonzalo, Philipp Sifft, Heidi Kapfelsberger, Merve Vurucu, Katharina Sarcletti, Stefanie Jacobson, Yulia Grinin, John A. Todd, Anette-G. Ziegler, Marcin L. Pekalski, Anette G. Ziegler, Annre Rochtus, An Jacobs, Hilde Morobé, Jasmin Paulus, Brontë Vrancken, Natalie Van den Driessche, Renka Van Heyste, Janne Houben, Veerle Vanhuyse, Sevina Dietz, Gita Gemulla, Manja Gottschalk-Schwarz, Sophie Heinke, Angela Hommel, Susann Kowal, Fabian Lander, Robert Morgenstern, Marc Weigelt, Sari Arabi, Raphael Hoffmann, Ruth Blechschmidt, Franziska Ehrlich, Anja Loff, Laura Galuschka, Ute Holtkamp, Nils Janzen, Sarah Landsberg, Erika Marquardt, Frank Roloff, Kerstin Semler, Thekla von dem Berge, Melanie Bunk, Simone Färber-Meisterjahn, Willi Grätz, Ines Greif, Melanie Herbst, Anna Hofelich, Benjamin Marcus, Annette Munzinger, Jasmin Ohli, Franziska Reinmüller, Tiziana Welzhofer, Sylwia Dybkowska, Katarzyna Dżygało, Dorota Owczarek, Katarzyna Popko, Agnieszka Skrobot, Anna Taczanowska, Beata Zduńczyk, Charlotte Brundin, Ida Jönsson, Sara Maroufkhani, Evelyn Tekum Amboh, Katarzyna Gajewska-Knapik, Elena Romero, Suzannah Twiss, Helen Gallon, Laura Gebbie, Fiona Jenkinson, Steven Pratt, Steve Robson, Claire Simmister, Evelyn Thomson, Eileen Walton

Publikováno v: BMJ Open, Vol 11, Iss 11 (2021)

Introduction The Global Platform for the Prevention of Autoimmune Diabetes-SINT1A Study is designed as a randomised, placebo-controlled, double-blind, multicentre, multinational, primary prevention study aiming to assess whether daily administration

Externí odkaz: https://doaj.org/article/32b6df3b92764c4e9ef877d2ae7501a4

Autoantibodies against ATP4A are a feature of the abundant autoimmunity that develops in first-degree relatives of patients with type 1 diabetes

Autor: Marie‐Luise Zielmann, Manja Jolink, Christiane Winkler, Anne Eugster, Denise Müller, Marlon Scholz, Anette‐G. Ziegler, Ezio Bonifacio

Publikováno v: Pediatr. Diabetes 23, 714-720 (2022)

OBJECTIVE: Type 1 diabetes is associated with autoantibodies to different organs that include the gut. The objective of the study was to determine the risk of developing gastric parietal cell autoimmunity in relation to other autoimmunity in individu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9166334a0dad855daf5c4986026d7156
https://pubmed.ncbi.nlm.nih.gov/35561070

Landmark models to define the age-adjusted risk of developing stage 1 type 1 diabetes across childhood and adolescence

Autor: Manja Jolink, Anette-G. Ziegler, Christiane Winkler, Verena S. Hoffmann, A. Knopff, Ezio Bonifacio, Andreas Weiß

Publikováno v: BMC Medicine, Vol 17, Iss 1, Pp 1-8 (2019)
BMC Med. 17:125 (2019)
BMC Medicine

Background Autoimmune diseases are often preceded by an asymptomatic autoantibody-positive phase. In type 1 diabetes, the detection of autoantibodies to pancreatic islet antigens in genetically at-risk children is prognostic for future clinical diabe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2256581a61133fc312d9d9445590b037
http://link.springer.com/article/10.1186/s12916-019-1360-3

Yield of a public health screening of children for islet autoantibodies in Bavaria, Germany

Autor: Anette-Gabriele Ziegler, Otto Laub, Desiree Dunstheimer, Peter Achenbach, Martin Lang, Markus Hippich, F Haupt, Karin Lange, Christiane Winkler, Robin Assfalg, Kerstin Kick, Manja Jolink, Katharina Warncke, Ezio Bonifacio

Publikováno v: JAMA

IMPORTANCE: Public health screening for type 1 diabetes in its presymptomatic stages may reduce disease severity and burden on a population level. OBJECTIVE: To determine the prevalence of presymptomatic type 1 diabetes in children participating in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e8f022cee77b1436ca644fffdc9c5d
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/76985

Age, HLA, and sex define a marked risk of organ-specific autoimmunity in first-degree relatives of patients with type 1 diabetes

Autor: Anette-G. Ziegler, Ezio Bonifacio, Christiane Winkler, A. Knopff, Peter Achenbach, Manja Jolink, Nana-Adjoa Kwarteng

Publikováno v: Diabetes Care 42, 1684-1691 (2019)

OBJECTIVE Autoimmune diseases can be diagnosed early through the detection of autoantibodies. The aim of this study was to determine the risk of organ-specific autoimmunity in individuals with a family history of type 1 diabetes. RESEARCH DESIGN AND

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7cf6d7f36dbf9bd5238d77bef7f0ecd
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=56359