Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Manisha Mehta"'
Autor:
Wei Zhang, Tianjiao Ji, Yang Li, Yueqin Zheng, Manisha Mehta, Chao Zhao, Andong Liu, Daniel S. Kohane
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Local anesthetic sustained release systems suffer from untriggered rapid drug release upon application. Here the authors overcome this issue by covalently linking tetracaine to a polymer gel via a photo-cleavable linkage, enabling light-triggered and
Externí odkaz:
https://doaj.org/article/f7f5610bdcbc4f8d89c158cdd6ef884d
Autor:
Chao Zhao, Andong Liu, Claudia M. Santamaria, Andre Shomorony, Tianjiao Ji, Tuo Wei, Akiva Gordon, Hannes Elofsson, Manisha Mehta, Rong Yang, Daniel S. Kohane
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
There is interest in developing long-lasting local anaesthetics for a range of applications. Here, the authors report on the application of tetrodotoxin conjugated to amphiphilic biodegradable polymer to reduce systemic toxicity, achieve sustained re
Externí odkaz:
https://doaj.org/article/ffb38a927fed4ae3b9ed75e944b4710c
Autor:
Yanfei Wang, Chi-Hsiu Liu, Tianjiao Ji, Manisha Mehta, Weiping Wang, Elizabeth Marino, Jing Chen, Daniel S. Kohane
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Current treatments of wet age-related macular degeneration require repeated injections of active drugs into the vitreous. Here Wang et al. develop nanoparticles that when injected intravenously can be targeted to the eye by irradiation with blue ligh
Externí odkaz:
https://doaj.org/article/c1aa796c9d924c3f95e0266f537c4573
Autor:
Wei Zhang, Tianjiao Ji, Abraham Offen, Manisha Mehta, Sherwood Hall, Daniel S. Kohane, Alina Y. Rwei, Chao Zhao, Xiaoran Deng, Yang Li
Publikováno v:
Nat Biomed Eng
Site-1 sodium channel blockers (S1SCBs) act as potent local anaesthetics, but they can cause severe systemic toxicity. Delivery systems can be used to reduce the toxicity, but the hydrophilicity of S1SCBs makes their encapsulation challenging. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67dc01476e6f00080336ddb6ae0517d5
https://doi.org/10.1038/s41551-021-00793-y
https://doi.org/10.1038/s41551-021-00793-y
Autor:
Alona Shagan, Yueqin Zheng, Wei Zhang, Xiaoran Deng, Manisha Mehta, Boaz Mizrahi, Sophie Lyon, Tianjiao Ji, Daniel S. Kohane, Andong Liu
Publikováno v:
ACS Applied Materials & Interfaces. 12:17314-17320
Existing tissue adhesives have a trade-off between adhesive strength and biocompatibility. Here, we report a series of biocompatible multiarmed polycaprolactones (PCL) as tissue adhesives that can be released from a hot glue gun and the length of eac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ca2d67ff6167b28081bfd991b543da
https://doi.org/10.1021/acsami.0c03478
https://doi.org/10.1021/acsami.0c03478
Autor:
Alina Y. Rwei, David Zurakowski, Manisha Mehta, Chao Zhao, Claudia M. Santamaria, Andre Shomorony, Daniel S. Kohane
Publikováno v:
Anesthesia & Analgesia. 129:709-717
Capsaicin, the active component of chili peppers, can produce sensory-selective peripheral nerve blockade. Coadministration of capsaicin and tetrodotoxin, a site-1 sodium channel blocker, can achieve a synergistic effect on duration of nerve blocks.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b132267cebc28980eac698ecd489f0
https://doi.org/10.1213/ane.0000000000004108
https://doi.org/10.1213/ane.0000000000004108
Autor:
Daniel S. Kohane, Manisha Mehta, Priscila Gava Mazzola, Thais Francine Ribeiro Alves, Rong Yang, Louise Lacalendola Tundisi, Marco Vinícius Chaud, Luiz Phellipe Pozzuto Borelli
Publikováno v:
Pharm Res
PURPOSE. Topical therapy of local disease (e.g. skin) is advantageous over oral therapy since there is less systemic drug distribution (so fewer side-effects), no first-pass effect, etc. However, patient compliance with topical therapy can be poor as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1128b5bb32a7e32be706086f0efb51ee
https://europepmc.org/articles/PMC8006178/
https://europepmc.org/articles/PMC8006178/
Autor:
Chao Zhao, Tianjiao Ji, Wei Zhang, Manisha Mehta, Yang Li, Andong Liu, Daniel S. Kohane, Yueqin Zheng
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
An on-demand anesthetic that would only take effect when needed and where the intensity of anesthesia could be easily adjustable according to patients’ needs would be highly desirable. Here, we design and synthesize a macromolecular prodrug (P407-C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c98675b06704c578a17e1db4dec5cd
http://europepmc.org/articles/PMC7210304
http://europepmc.org/articles/PMC7210304
Autor:
Alina Y. Rwei, Daniel S. Kohane, Tianjiao Ji, Bruce Wang, Christopher B. Weldon, Weiping Wang, Minh-Thuy Nguyen, Robert P. Marini, Jonathan H. Tsui, Chao Zhao, Yi Hao, Manisha Mehta
Publikováno v:
ACS Nano. 13:18-25
Intravenous regional anesthesia (IVRA; Bier block) is commonly used to anesthetize an extremity for surgery. Limitations of the procedure include pain from the required tourniquet, the toxicity that can occur from systemic release of local anesthetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69406b6a8aa5f5dfe99be07cecd5a695
https://doi.org/10.1021/acsnano.8b05408
https://doi.org/10.1021/acsnano.8b05408
Autor:
Arun Soni, Manisha Mehta
Publikováno v:
Current Medicine Research and Practice. 10:34-35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4c1ec5b103951773bb952f89d0d1db8
https://doi.org/10.1016/j.cmrp.2019.12.003
https://doi.org/10.1016/j.cmrp.2019.12.003