Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Manisha C. Yadav"'
Autor:
Karla J. Suchacki, Nicholas M. Morton, Calvin Vary, Carmen Huesa, Manisha C. Yadav, Benjamin J. Thomas, Sophie Turban, Lutz Bunger, Derek Ball, Martin E. Barrios-Llerena, Anyonya R. Guntur, Zohreh Khavandgar, William P. Cawthorn, Mathieu Ferron, Gérard Karsenty, Monzur Murshed, Clifford J. Rosen, Vicky E. MacRae, Jose Luis Millán, Colin Farquharson
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-20 (2020)
Abstract Background The classical functions of the skeleton encompass locomotion, protection and mineral homeostasis. However, cell-specific gene deletions in the mouse and human genetic studies have identified the skeleton as a key endocrine regulat
Externí odkaz:
https://doaj.org/article/23dc81b350d5458086f9e23af1515cc1
Autor:
Alexei Y. Savinov, Maryam Salehi, Manisha C. Yadav, Ilian Radichev, José Luis Millán, Olga V. Savinova
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 4, Iss 12, Pp n/a-n/a (2015)
Background Ectopic vascular calcification is a common condition associated with aging, atherosclerosis, diabetes, and/or chronic kidney disease. Smooth muscle cells are the best characterized source of osteogenic progenitors in the vasculature; howev
Externí odkaz:
https://doaj.org/article/0e808a3ff679458d9eef2983352b86e0
Autor:
Filippo Romanelli, AnthonyMarco Corbo, Maryam Salehi, Manisha C Yadav, Soha Salman, David Petrosian, Omid J Rashidbaigi, Jesse Chait, Jes Kuruvilla, Maria Plummer, Ilian Radichev, Kenneth B Margulies, A Martin Gerdes, Anthony B Pinkerton, José Luis Millán, Alexei Y Savinov, Olga V Savinova
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186426 (2017)
Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelium leads to arterial calcification in mice. The purpose of this study was to examine the effect of elevated endothelial TNAP on coronary atherosclerosis. In addition, we aim
Externí odkaz:
https://doaj.org/article/9bda24ef25a64376a0b1a3005f03b32a
Autor:
Konstantinos Sousounis, Feng Qi, Manisha C Yadav, José Luis Millán, Fubito Toyama, Chikafumi Chiba, Yukiko Eguchi, Goro Eguchi, Panagiotis A Tsonis
Publikováno v:
eLife, Vol 4 (2015)
Newts have the ability to repeatedly regenerate their lens even during ageing. However, it is unclear whether this regeneration reflects an undisturbed genetic activity. To answer this question, we compared the transcriptomes of lenses, irises and ta
Externí odkaz:
https://doaj.org/article/5817a24e55474510857230fd26ef1a87
Autor:
Martin E. Barrios-Llerena, Derek Ball, Zohreh Khavandgar, Lutz Bünger, Anyonya R. Guntur, Colin Farquharson, Karla J. Suchacki, Clifford J. Rosen, Sophie Turban, Monzur Murshed, Mathieu Ferron, Carmen Huesa, Nicholas M. Morton, Benjamin J. Thomas, José Luis Millán, William P. Cawthorn, Manisha C. Yadav, Vicky E MacRae, Gerard Karsenty, Calvin P.H. Vary
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-20 (2020)
Suchacki, K, Morton, N M, Vary, C, Huesa, C, Yadav, M, Thomas, B, Turban, S, Bungar, L, Ball, D, Barrios-Llerena, M, Guntur, A, Khavandgar, Z, Cawthorn, W P, Ferron, M, Karsenty, G, Murshed, M, Rosen, C J, MacRae, V, Millan, J-L & Farquharson, C 2020, ' PHOSPHO1 is a skeletal regulator of insulin resistance and obesity ', BMC Biology, vol. 18, no. 149, 149 (2020) . https://doi.org/10.1186/s12915-020-00880-7
BMC Biology
Suchacki, K, Morton, N M, Vary, C, Huesa, C, Yadav, M, Thomas, B, Turban, S, Bungar, L, Ball, D, Barrios-Llerena, M, Guntur, A, Khavandgar, Z, Cawthorn, W P, Ferron, M, Karsenty, G, Murshed, M, Rosen, C J, MacRae, V, Millan, J-L & Farquharson, C 2020, ' PHOSPHO1 is a skeletal regulator of insulin resistance and obesity ', BMC Biology, vol. 18, no. 149, 149 (2020) . https://doi.org/10.1186/s12915-020-00880-7
BMC Biology
Background The classical functions of the skeleton encompass locomotion, protection and mineral homeostasis. However, cell-specific gene deletions in the mouse and human genetic studies have identified the skeleton as a key endocrine regulator of met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4365ed147ba67b9e188e1dce16f6b7
https://doi.org/10.1186/s12915-020-00880-7
https://doi.org/10.1186/s12915-020-00880-7
Autor:
Martin E. Barrios-Llerena, Calvin P.H. Vary, Mathieu Ferron, Manisha C. Yadav, Monzur Murshed, Zohreh Khavandgar, William P. Cawthorn, Lutz Bünger, Anyonya R. Guntur, Benjamin J. Thomas, Sophie Rajoanah, Clifford J. Rosen, Karla J. Suchacki, Nik M. Morton, Derek Ball, MacRae, Gerard Karsenty, Colin Farquharson, José Luis Millán, Carmen Huesa
The skeleton is recognised as a key endocrine regulator of metabolism. Here we show that mice lacking the bone mineralization enzyme PHOSPHO1 (Phospho1-/-) exhibited improved basal glucose homeostasis and resisted high-fat-diet induced weight gain an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5d80f5f97cdb52f655f95c164794c00
Autor:
Sonoko Narisawa, José Luis Millán, Kunal Bhattacharya, Manisha C. Yadav, Bengt Fadeel, Laurent Beck, Robert L. Sah, Massimo Bottini, Esther Cory, Colin Farquharson, Pia Kuss
Publikováno v:
Journal of Bone and Mineral Research. 31:1275-1286
We have previously shown that ablation of either the Phospho1 or Alpl gene, encoding PHOSPHO1 and tissue-nonspecific alkaline phosphatase (TNAP) respectively, lead to hyperosteoidosis, but that their chondrocyte-derived and osteoblast-derived matrix
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae575eec8719a8f7fc3474c8bdf38031
https://doi.org/10.1002/jbmr.2790
https://doi.org/10.1002/jbmr.2790
Autor:
Sandeep C. Chaudhary, Dobrawa Napierala, José Luis Millán, Massimo Bottini, Manisha C. Yadav, Callie G. Mobley, Terje Dokland, Maria Kuzynski, Odile Kellermann, Anne Poliard, Elia Beniash
Publikováno v:
Matrix Biology. :284-300
Mineralization is a process of deposition of calcium phosphate crystals within a fibrous extracellular matrix (ECM). In mineralizing tissues, such as dentin, bone and hypertrophic cartilage, this process is initiated by a specific population of extra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aba87406bd2b5ddef5436041ec56652a
https://doi.org/10.1016/j.matbio.2016.02.003
https://doi.org/10.1016/j.matbio.2016.02.003
Autor:
T.N. Kolli, M. Ao, Sonoko Narisawa, L Zweifler, Martha J. Somerman, Manisha C. Yadav, José Luis Millán, Pia Kuss, Brian L. Foster, Colin Farquharson, H.F. Wimer
Publikováno v:
Zweifler, L, Ao, M, Yadav, M, Kuss, P, Narisawa, S, Kolli, T, Wimer, H F, Farquharson, C, Somerman, MJ, Millan, J L & Foster, B 2016, ' Role of PHOSPHO1 in periodontal development and function ', Journal of Dental Research, vol. 95, no. 7, pp. 742-751 . https://doi.org/10.1177/0022034516640246
The tooth root and periodontal apparatus, including the acellular and cellular cementum, periodontal ligament (PDL), and alveolar bone, are critical for tooth function. Cementum and bone mineralization is regulated by factors including enzymes and ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7459431d4c892e89acf9c7c8dda01313
https://doi.org/10.1177/0022034516640246
https://doi.org/10.1177/0022034516640246
Autor:
Tina Kiffer-Moreira, José Luis Millán, Colin Farquharson, Manisha C. Yadav, Carmen Huesa, Dean Houston
Publikováno v:
Huesa, C, Houston, D, Kiffer-Moreira, T, Yadav, M M, Millan, J L & Farquharson, C 2015, ' The Functional co-operativity of Tissue-Nonspecific Alkaline Phosphatase (TNAP) and PHOSPHO1 during initiation of Skeletal Mineralization ', Biochemistry and biophysics reports, vol. 4, pp. 196-201 . https://doi.org/10.1016/j.bbrep.2015.09.013
Phosphatases are recognised to have important functions in the initiation of skeletal mineralization. Tissue-nonspecific alkaline phosphatase (TNAP) and PHOSPHO1 are indispensable for bone and cartilage mineralization but their functional relationshi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b9e8317742ceea862d17cedc558d378