Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Manish Kesherwani"'
Autor:
Simon Miller, Manish Kesherwani, Priscilla Chan, Yoshiko Nagai, Moeri Yagi, Jamie Cope, Florence Tama, Steve A. Kay, Tsuyoshi Hirota
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(40)
The mammalian cryptochrome isoforms, CRY1 and CRY2, are core circadian clock regulators that work redundantly. Recent studies revealed distinct roles of these closely related homologs in clock output pathways. Isoform-selective control of CRY1 and CR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a48ffdaa9ac3d85079b357781bf955
https://pubmed.ncbi.nlm.nih.gov/36161947
https://pubmed.ncbi.nlm.nih.gov/36161947
Publikováno v:
Journal of Chemical Information and Modeling. 58:1638-1651
Thiamine pyrophosphate (TPP) riboswitch is a cis-regulatory element in the noncoding region of mRNA. The aptamer domain of TPP riboswitch detects the high abundance of coenzyme thiamine pyrophosphate (TPP) and modulates the gene expression for thiami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98608ff4851c59b719e2ec151bdd789
https://doi.org/10.1021/acs.jcim.8b00155
https://doi.org/10.1021/acs.jcim.8b00155
Autor:
Antonydhason Vimala, M. Michael Gromiha, K. Vishnu Priya, Manish Kesherwani, Gnanendra Shanmugam, Devadasan Velmurugan, Shanmugam Anusuya
Publikováno v:
Current Protein & Peptide Science. 19:537-561
Identifying the interactions between drugs and target proteins is a key step in drug discovery. This not only aids to understand the disease mechanism, but also helps to identify unexpected therapeutic activity or adverse side effects of drugs. Hence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01cb5de6f953e1bd7abe760aef46dca1
https://doi.org/10.2174/1389203718666161108091609
https://doi.org/10.2174/1389203718666161108091609
Autor:
Devadasan Velmurugan, R. Manjunatha Kini, Manisha Choudhury, Manish Kesherwani, Ryan J.R. McCleary
Publikováno v:
Toxicon. 135:33-42
Snake venoms are mixtures of biologically-active proteins and peptides, and several studies have described the characteristics of some of these toxins. However, complete proteomic profiling of the venoms of many snake species has not yet been done. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff32c4cbe043f909d993887c59cffd3
https://doi.org/10.1016/j.toxicon.2017.06.005
https://doi.org/10.1016/j.toxicon.2017.06.005
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 36:1306-1328
Nicotinamide Phosphoribosyltransferase (NAMPT) is a rate-limiting enzyme in the biosynthesis of NAD. Cancer cells have elevated poly [ADP-Ribose] polymerase 1 (PARP) activity as well as the immense necessity of ATP: thereby consuming NAD at a higher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365c7bf6f386978091a254809d7e16e3
https://doi.org/10.1080/07391102.2017.1322004
https://doi.org/10.1080/07391102.2017.1322004
Fasciola gigantica thioredoxin glutathione reductase: Biochemical properties and structural modeling
Publikováno v:
International Journal of Biological Macromolecules. 89:152-160
Platyhelminth thioredoxin glutathione reductase (TGR) is a multifunctional enzyme that crosstalk between the conventional thioredoxin (Trx) and glutathione (GSH) system. It has been validated as a potential drug target in blood flukes. In the present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800411be3abb57bce35ade44d5d9d3b9
https://doi.org/10.1016/j.ijbiomac.2016.04.063
https://doi.org/10.1016/j.ijbiomac.2016.04.063
Autor:
Manish Kesherwani, Narasimhan Srinivasan, Subramani Karthikeyan, Karthik Ananth Mani, Devadasan Velmurugan, Prakasarao Aruna, Ganesan Bharanidharan, Singaravelu Ganesan
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 35:817-828
4-[3-acetyl-5-(acetylamino)-2,3-dihydro-1,3,4-thiadiazole-2-yl]phenyl benzoate from the family of thiadiazole derivative has been newly synthesized. It has good anticancer activity as well as antibacterial and less toxic in nature, its binding charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3ae42a9f9d9f9c772d4d4e8d352867
https://doi.org/10.1080/07391102.2016.1162751
https://doi.org/10.1080/07391102.2016.1162751
Undecaprenyl phosphate (C55-P) acts as carrier lipid in the synthesis of peptidoglycan, which is de novo synthesized from dephosphorylation of undecaprenyl pyrophosphate (C55-PP). The phosphatidylglycerol phosphate phosphatase B (PgpB) catalyzes the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05eeaa195750b5f84e058429f3e4414a
Autor:
Devadasan Velmurugan, Manish Kesherwani, Anantha Krishnan Dhanabalan, Krishnasamy Gunasekaran
Publikováno v:
Journal of molecular graphicsmodelling. 76
Inhibition of β-Secretase (BACE1) is crucial for the treatment of Alzheimer's disease (AD). Availability of BACE1 crystal structures in both apo and complexed forms enables to find structure-based BACE1 inhibitors for controlling AD. There are two c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306df9bf23c57fd030328df2acd434c6
https://pubmed.ncbi.nlm.nih.gov/28710924
https://pubmed.ncbi.nlm.nih.gov/28710924
Autor:
Velmurugan Devadasan, Barij Nayan Sinha, Venkatesan Jayaprakash, Ajay Kumar Timiri, Manish Kesherwani, S. Subasri, Vishwanathan Vijayan
Publikováno v:
Journal of Pharmaceutical Chemistry. 1:28-32
N-benzyl-2-(4,6-diaminopyrimidin-2-ylthio)-acetamide, was synthesized by the reaction of 4,6-diamino-pyrimidine-2-thiol with 2-chloro-N-benzyl acetamide in the presence of potassium hydroxide under reflux conditions and crystallized. X-ray diffractio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f5b1c2f9d8cf4ebf9f8fc9ea26f4354
https://doi.org/10.14805/jphchem.2014.art9
https://doi.org/10.14805/jphchem.2014.art9