Zobrazeno 1 - 10
of 512
pro vyhledávání: '"Manish K. Aghi"'
Autor:
Saket Jain, Jonathan W. Rick, Rushikesh S. Joshi, Angad Beniwal, Jordan Spatz, Sabraj Gill, Alexander Chih-Chieh Chang, Nikita Choudhary, Alan T. Nguyen, Sweta Sudhir, Eric J. Chalif, Jia-Shu Chen, Ankush Chandra, Alexander F. Haddad, Harsh Wadhwa, Sumedh S. Shah, Serah Choi, Josie L. Hayes, Lin Wang, Garima Yagnik, Joseph F. Costello, Aaron Diaz, Dieter Henrik Heiland, Manish K. Aghi
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 5 (2023)
Cancer-associated fibroblasts (CAFs) were presumed absent in glioblastoma given the lack of brain fibroblasts. Serial trypsinization of glioblastoma specimens yielded cells with CAF morphology and single-cell transcriptomic profiles based on their la
Externí odkaz:
https://doaj.org/article/14cced134af940a49b4d6fa72e0c4da9
Autor:
Michael M. Safaee, Elaina J. Wang, Saket Jain, Jia-Shu Chen, Sabraj Gill, Allison C. Zheng, Joseph H. Garcia, Angad S. Beniwal, Y. Tran, Alan T. Nguyen, Melissa Trieu, Kevin Leung, Jim Wells, James M. Maclean, Keith Wycoff, Manish K. Aghi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Glioblastoma (GBM) is the most common primary brain tumor with a median survival under two years. Using in silico and in vitro techniques, we demonstrate heterogeneous expression of CD97, a leukocyte adhesion marker, in human GBM. Beyond its
Externí odkaz:
https://doaj.org/article/401b7d931a4840b5b87625463dbdb581
Autor:
Elaina J. Wang, Alexander F. Haddad, Jacob S. Young, Ramin A. Morshed, Joshua P. H. Wu, Diana M. Salha, Nicholas Butowski, Manish K. Aghi
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
Meningiomas are the most common primary intracranial neoplasm. While traditionally viewed as benign, meningiomas are associated with significant patient morbidity, and certain meningioma subgroups display more aggressive and malignant behavior with h
Externí odkaz:
https://doaj.org/article/6d971e4b054a43619f36828b44589102
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Pituitary adenomas (PAs) have been shown to cause excess cardiovascular disease comorbidity and mortality. Cerebrovascular disease (CeVD) is a small subset of cardiovascular disease with high morbidity, and its risk in patients with pituitary adenoma
Externí odkaz:
https://doaj.org/article/0bc10111f29d4cebb07bea703086acd9
Autor:
Husam Babikir, Lin Wang, Karin Shamardani, Francisca Catalan, Sweta Sudhir, Manish K. Aghi, David R. Raleigh, Joanna J. Phillips, Aaron A. Diaz
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-22 (2021)
Abstract Background Recent single-cell transcriptomic studies report that IDH-mutant gliomas share a common hierarchy of cellular phenotypes, independent of genetic subtype. However, the genetic differences between IDH-mutant glioma subtypes are prog
Externí odkaz:
https://doaj.org/article/1f912e20cb9c45bfa17d01103b13cc81
Autor:
Melike Pekmezci, Ramin A. Morshed, Pranathi Chunduru, Balaji Pandian, Jacob Young, Javier E. Villanueva-Meyer, Tarik Tihan, Emily A. Sloan, Manish K. Aghi, Annette M. Molinaro, Mitchel S. Berger, Shawn L. Hervey-Jumper
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract In the management of diffuse gliomas, the identification and removal of tumor at the infiltrative margin remains a central challenge. Prior work has demonstrated that fluorescence labeling tools and radiographic imaging are useful surgical a
Externí odkaz:
https://doaj.org/article/d0f2d439f7c344898da0426b8b2216a6
Autor:
Jacob S. Young, Reilly L. Kidwell, Allison Zheng, Alex F. Haddad, Manish K. Aghi, David R. Raleigh, Jessica D. Schulte, Nicholas A. Butowski
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Meningiomas are the most common non-metastatic brain tumors, and although the majority are relatively slow-growing and histologically benign, a subset of meningiomas are aggressive and remain challenging to treat. Despite a standard of care that incl
Externí odkaz:
https://doaj.org/article/ce5f3dc4eefb4fa8ab0de859a96b0799
Autor:
Stephen T. Magill, Harish N. Vasudevan, Kyounghee Seo, Javier E. Villanueva-Meyer, Abrar Choudhury, S. John Liu, Melike Pekmezci, Sarah Findakly, Stephanie Hilz, Sydney Lastella, Benjamin Demaree, Steve E. Braunstein, Nancy Ann Oberheim Bush, Manish K. Aghi, Philip V. Theodosopoulos, Penny K. Sneed, Adam R. Abate, Mitchel S. Berger, Michael W. McDermott, Daniel A. Lim, Erik M. Ullian, Joseph F. Costello, David R. Raleigh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Meningiomas are heterogeneous tumours. Here, the authors analysed genetic, epigenetic, and transcriptomic features across spatially-distinct meningioma samples to identify molecular programs underlying tumorigenesis that can be detected preoperativel
Externí odkaz:
https://doaj.org/article/009c5504e81841cb823079d832c9273c
Autor:
Calixto-Hope G. Lucas, Rohit Gupta, Pamela Doo, Julieann C. Lee, Cathryn R. Cadwell, Biswarathan Ramani, Jeffrey W. Hofmann, Emily A. Sloan, Bette K. Kleinschmidt-DeMasters, Han S. Lee, Matthew D. Wood, Marjorie Grafe, Donald Born, Hannes Vogel, Shahriar Salamat, Diane Puccetti, David Scharnhorst, David Samuel, Tabitha Cooney, Elaine Cham, Lee-way Jin, Ziad Khatib, Ossama Maher, Gabriel Chamyan, Carole Brathwaite, Serguei Bannykh, Sabine Mueller, Cassie N. Kline, Anu Banerjee, Alyssa Reddy, Jennie W. Taylor, Jennifer L. Clarke, Nancy Ann Oberheim Bush, Nicholas Butowski, Nalin Gupta, Kurtis I. Auguste, Peter P. Sun, Jarod L. Roland, Corey Raffel, Manish K. Aghi, Philip Theodosopoulos, Edward Chang, Shawn Hervey-Jumper, Joanna J. Phillips, Melike Pekmezci, Andrew W. Bollen, Tarik Tihan, Susan Chang, Mitchel S. Berger, Arie Perry, David A. Solomon
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-17 (2020)
Abstract The FGFR1 gene encoding fibroblast growth factor receptor 1 has emerged as a frequently altered oncogene in the pathogenesis of multiple low-grade neuroepithelial tumor (LGNET) subtypes including pilocytic astrocytoma, dysembryoplastic neuro
Externí odkaz:
https://doaj.org/article/3a46ceae1a2346d09a785ac62bd3c17d
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
Glioblastoma is the most aggressive brain tumor with a median survival ranging from 6.2 to 16.7 months. The complex interactions between the tumor and the cells of tumor microenvironment leads to tumor evolution which ultimately results in treatment
Externí odkaz:
https://doaj.org/article/46a1005826994015a265925c01590f44