Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Manish Datt"'
Autor:
Ankita Sharma, Sukhleen Kaur, Abubakar Wani, Dilpreet Kour, Mehboob Ali, Syed Mudassir Ali, Lakhvinder Singh, Abhishek Gour, Utpal Nandi, Manish Datt, Parduman Raj Sharma, Conrad C Weihl, Gurdarshan Singh, Ajay Kumar
Publikováno v:
Autophagy Reports, Vol 3, Iss 1 (2024)
ABSTRACTBeing present in substantial numbers, astrocytes play an indispensable role in maintaining homeostasis in the brain. However, their positive or negative involvement in pathological conditions in the brain has not been explored much. In recent
Externí odkaz:
https://doaj.org/article/25c78f4100fa46be8e209b6d79865ea0
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167897 (2016)
[This corrects the article DOI: 10.1371/journal.pone.0162956.].
Externí odkaz:
https://doaj.org/article/c27b515168e747c38ae7267ded83f596
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162956 (2016)
Methylation of DNA and histone proteins are mutually involved in the epigenetic regulation of gene expression mediated by DNA methyltransferases (DNMTs) and histone methyltransferases (HMTs). DNMTs methylate cytosine residues within gene promoters, w
Externí odkaz:
https://doaj.org/article/bb9e64c8709f4d0584469810af47114a
Autor:
Priyanka Chahar, Manjeri Kaushik, Sarvajeet Singh Gill, Surendra Kumar Gakhar, Natrajan Gopalan, Manish Datt, Amit Sharma, Ritu Gill
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128507 (2015)
Despite a significant drop in malaria deaths during the past decade, malaria continues to be one of the biggest health problems around the globe. WD40 repeats (WDRs) containing proteins comprise one of the largest and functionally diverse protein sup
Externí odkaz:
https://doaj.org/article/44a0f6b9ac3748608866f8bd22fa4814
Autor:
Uri R Mbonye, Giridharan Gokulrangan, Manish Datt, Curtis Dobrowolski, Maxwell Cooper, Mark R Chance, Jonathan Karn
Publikováno v:
PLoS Pathogens, Vol 9, Iss 5, p e1003338 (2013)
The HIV transactivator protein, Tat, enhances HIV transcription by recruiting P-TEFb from the inactive 7SK snRNP complex and directing it to proviral elongation complexes. To test the hypothesis that T-cell receptor (TCR) signaling induces critical p
Externí odkaz:
https://doaj.org/article/8dcba0705c894169b56811da81068450
Autor:
Manish Datt
Publikováno v:
Computational biology and chemistry. 95
Aminoacyl-tRNA synthetases are an indispensable component of ribosomal protein translational machinery and Plasmodium Tyrosyl-tRNA synthetase (PfTyrRS) is a validated drug target. This manuscript illustrates the dynamic conformational landscape of Pf
Publikováno v:
3 Biotech
Malaria remains the leading cause of deaths globally, despite significant advancement towards understanding its epidemiology and availability of multiple therapeutic interventions. Poor efficacy of the approved vaccine, and the rapid emergence of ant
Autor:
Sanjeev Kumar Digra, Abubakar Wani, Ajay Kumar, Pankaj Chibber, Surjeet Singh, Gurdarshan Singh, Mehak Gupta, Ram A. Vishwakarma, Aitizaz Ul Ahsan, Sandip B. Bharate, Mehboob Ali, Manish Datt
Publikováno v:
Toxicology and Applied Pharmacology. 423:115582
NLRP3 inflammasome is involved in several chronic inflammatory diseases. The inflammatory effect of the NLRP3 inflammasome is executed through IL-1β and IL-18. Therefore, IL-1β is one of the primary targets in chronic inflammatory conditions. Howev
Autor:
Abbey L. Perl, Yiannis A. Ioannou, Avi Ma'ayan, Shen Yao, Analisa DiFeo, Rosalie C. Sears, Qiaonan Duan, Giridharan Gokulrangan, Zhizhi Wang, Caitlin M. O’Connor, Matthew D. Galsky, Jaya Sangodkar, Danica Wiredja, Eric Yuan, David L. Brautigan, Mark R. Chance, Manish Datt, Heather M. Giannini, Kimberly McClinch, Daniel McQuaid, Sahar Mazhar, Neil S. Dhawan, Elena Svenson, Michael Ohlmeyer, Caroline C. Farrington, Alice C. Levine, Rita Tohme, Lifu Wang, Janna Kiselar, Goutham Narla, Rita A. Avelar, Shozeb Haider, Agnes Stachnik, David B. Kastrinsky, Daniela Schlatzer, Divya Hoon, Wenqing Xu, Alain C. Borczuk, Neelesh Sharma, Nilesh Zaware, Vickram Gidwani, Edward Y. Chen, Sudeh Izadmehr, Blake E. Smith, Daniel Leonard
Publikováno v:
Journal of Clinical Investigation. 127:2081-2090
Targeted cancer therapies, which act on specific cancer-associated molecular targets, are predominantly inhibitors of oncogenic kinases. While these drugs have achieved some clinical success, the inactivation of kinase signaling via stimulation of en
Autor:
Manish Datt
Publikováno v:
Biophysical Journal. 118:46a