Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Manish, Rauthan"'
Autor:
Manish Rauthan, Jianke Gong, Jinzhi Liu, Zhaoyu Li, Seth A. Wescott, Jianfeng Liu, X.Z. Shawn Xu
Publikováno v:
Cell Reports, Vol 21, Iss 6, Pp 1434-1441 (2017)
Summary: Chronic exposure to nicotine upregulates nicotinic acetylcholine receptors (nAChRs), and such upregulation is critical for the development of nicotine dependence in humans and animal models. However, how nicotine upregulates nAChRs is not we
Externí odkaz:
https://doaj.org/article/b34060c438d94eddb69cbe83590e0dc7
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170613 (2017)
Myosin storage myopathy is a protein aggregate myopathy associated with the characteristic subsarcolemmal accumulation of myosin heavy chain in muscle fibers. Despite similar histological findings, the clinical severity and age of onset are highly va
Externí odkaz:
https://doaj.org/article/cc03e4bb425f4e528cf747276ca689e5
Autor:
Emma Svensk, Ranjan Devkota, Marcus Ståhlman, Parmida Ranji, Manish Rauthan, Fredrik Magnusson, Sofia Hammarsten, Maja Johansson, Jan Borén, Marc Pilon
Publikováno v:
PLoS Genetics, Vol 12, Iss 6, p e1006112 (2016)
[This corrects the article DOI: 10.1371/journal.pgen.1005982.].
Externí odkaz:
https://doaj.org/article/8aae184e117c4338aa3b04907f77ca33
Autor:
Emma Svensk, Ranjan Devkota, Marcus Ståhlman, Parmida Ranji, Manish Rauthan, Fredrik Magnusson, Sofia Hammarsten, Maja Johansson, Jan Borén, Marc Pilon
Publikováno v:
PLoS Genetics, Vol 12, Iss 4, p e1005982 (2016)
In spite of the worldwide impact of diabetes on human health, the mechanisms behind glucose toxicity remain elusive. Here we show that C. elegans mutants lacking paqr-2, the worm homolog of the adiponectin receptors AdipoR1/2, or its newly identified
Externí odkaz:
https://doaj.org/article/fc6b3cb3eb264188b96bcdea9988f39f
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e100033 (2014)
HMG-CoA reductase is the rate-limiting enzyme in the mevalonate pathway and the target of cholesterol-lowering statins. We characterized the C. elegans hmgr-1(tm4368) mutant, which lacks HMG-CoA reductase, and show that its phenotypes recapitulate th
Externí odkaz:
https://doaj.org/article/7d59a3acdccf4e4fb36f763e3745c8bd
Publikováno v:
G3: Genes|Genomes|Genetics
The mevalonate pathway is responsible for the synthesis of cholesterol, coenzyme Q, and prenyl groups essential for small GTPase modification and function, and for the production of dolichols important for protein glycosylation. Statins, i.e., choles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb135511dd78e0af7ac08774f84aaea
https://doi.org/10.1534/g3.115.018598
https://doi.org/10.1534/g3.115.018598
Publikováno v:
Life Sciences. 92:410-414
Drug addiction is a psychiatric disease state, wherein a drug is impulsively and compulsively self-administered despite negative consequences. This repeated administration results in permanent changes to nervous system physiology and architecture. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683787d2fc50589e26f7fb85e93a42f0
https://doi.org/10.1016/j.lfs.2012.07.008
https://doi.org/10.1016/j.lfs.2012.07.008
Publikováno v:
Developmental Biology. 311(1):185-199
The invariant cell-cell interactions occurring during C. elegans development offer unique opportunities to discover how growing axons may receive guidance cues from neighboring cells. The mnm-2 mutant was isolated because of its defects in the axon t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e70bb16883981e95627a7b21b606332
Autor:
Manish, Rauthan, Marc, Pilon
Publikováno v:
Worm
We previously showed that inhibition of the mevalonate pathway in C. elegans causes inhibition of protein prenylation, developmental arrest and lethality. We also showed that constitutive activation of the mitochondrial unfolded protein response, UPR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::76fde22064feba94a928f3f33d1f23e1
https://pubmed.ncbi.nlm.nih.gov/27123370
https://pubmed.ncbi.nlm.nih.gov/27123370
Publikováno v:
Microbes and Infection. 8:92-104
Replication-defective recombinant adenoviruses (RAds) were constructed that synthesized the pre-membrane and envelope (E) proteins of Japanese encephalitis virus (JEV). Recombinant virus RAdEa synthesized Ea, the membrane-anchored E protein, and RAdE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c737be8ea66bee046c606b33610ee6b
https://doi.org/10.1016/j.micinf.2005.05.023
https://doi.org/10.1016/j.micinf.2005.05.023