Agr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103+ dendritic cell IL-23-dependent ileocolitis

Autor: Monica Viladomiu, Manirath Khounlotham, Belgin Dogan, Svetlana F. Lima, Ahmed Elsaadi, Emre Cardakli, Jim G. Castellanos, Charles Ng, Jeremy Herzog, Alexi A. Schoenborn, Melissa Ellermann, Bo Liu, Shiying Zhang, Ajay S. Gulati, R. Balfour Sartor, Kenneth W. Simpson, Steven M. Lipkin, Randy S. Longman

Publikováno v: Cell Reports. 41:111637

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2197ec950b7940e76332bbedff16c2db
https://doi.org/10.1016/j.celrep.2022.111637

ADHERENT-INVASIVEE. COLI PROMOTE ER STRESS TO SUPPORT IL23R-DRIVEN AGR2-DEPENDENT ILEOCOLITIS

Autor: Monica Viladomiu, Manirath Khounlotham, Belgin Dogan, Svetlana Lima, Ahmed Elsaadi, Jeremy Herzog, Alexi Schoenborn, Melissa Ellermann, Bo Liu, Shiying Zhang, Ajay Gulati, R Balfour Sartor, Kenneth Simpson, Steve Lipkin, Randy Longman

Publikováno v: Inflammatory Bowel Diseases. 28:S56-S56

Anterior gradient 2 (AGR2) is an epithelial protein disulfide isomerase critical for mucus production and endoplasmic reticulum (ER) homeostasis. Loss-of-function genetic variants in AGR2 are associated with Crohn’s disease (CD), and AGR2-deficient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dfda53846cc9d336f71fe648fe79f856
https://doi.org/10.1093/ibd/izac015.087

Compromised intestinal barrier induces adaptive immune responses that protect from colitis

Autor: Timothy L. Denning, Manirath Khounlotham, Eric Peatman, Stefan Koch, Oscar Medina-Contreras, Charles A. Parkos, Asma Nusrat, Wooki Kim, Porfirio Nava

Publikováno v: The FASEB Journal. 26

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c55fcda457613d601ae00ae7ec1be86
https://doi.org/10.1096/fasebj.26.1_supplement.136.6

Physical interaction between RRS1-R, a protein conferring resistance to bacterial wilt, and PopP2, a type III effector targeted to the plant nucleus

Autor: Dong Xin Feng, Imre E. Somssich, Laurent Deslandes, Manirath Khounlotham, Yves Marco, Stéphane Genin, Jocelyne Olivier, Nemo Peeters, Christian Boucher

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2003, 100 (13), pp.8024-8029

RRS1-R confers broad-spectrum resistance to several strains of the causal agent of bacterial wilt, Ralstonia solanacearum . Although genetically defined as recessive, this R gene encodes a protein whose structure combines the TIR-NBS-LRR domains foun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c3af5cc248e6ad27f465b8c7e06bf81
https://hal.inrae.fr/hal-02671497