Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Manimozhi Manivannan"'
Autor:
Daniel H. Hovelson, Andrew S. McDaniel, Andi K. Cani, Bryan Johnson, Kate Rhodes, Paul D. Williams, Santhoshi Bandla, Geoffrey Bien, Paul Choppa, Fiona Hyland, Rajesh Gottimukkala, Guoying Liu, Manimozhi Manivannan, Jeoffrey Schageman, Efren Ballesteros-Villagrana, Catherine S. Grasso, Michael J. Quist, Venkata Yadati, Anmol Amin, Javed Siddiqui, Bryan L. Betz, Karen E. Knudsen, Kathleen A. Cooney, Felix Y. Feng, Michael H. Roh, Peter S. Nelson, Chia-Jen Liu, David G. Beer, Peter Wyngaard, Arul M. Chinnaiyan, Seth Sadis, Daniel R. Rhodes, Scott A. Tomlins
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 17, Iss 4, Pp 385-399 (2015)
Next-generation sequencing (NGS) has enabled genome-wide personalized oncology efforts at centers and companies with the specialty expertise and infrastructure required to identify and prioritize actionable variants. Such approaches are not scalable,
Externí odkaz:
https://doaj.org/article/e35c27ad1bb744a8a1d6afe2cf1f770b
Autor:
Martin Carroll, Ahmet Zehir, Sombeet Sahu, Isabelle S. Csete, Benjamin Demaree, Cyrille L. Delley, Aaron D. Viny, Minal Patel, Christopher Famulare, Chrysanthi Ainali, Manimozhi Manivannan, Raajit K. Rampal, Tiffany R. Merlinsky, Michael Bowman, Aaron D Goldberg, Adam R. Abate, Kelly L. Bolton, Sara E. Meyer, Robert L. Bowman, Pedro Mendez, Linde A. Miles, Aik Ooi, Robert Durruthy-Durruthy, Ross L. Levine
Publikováno v:
Nature
Nature, vol 587, iss 7834
Nature, vol 587, iss 7834
Myeloid malignancies, including acute myeloid leukaemia (AML), arise from the expansion of haematopoietic stem and progenitor cells that acquire somatic mutations. Bulk molecular profiling has suggested that mutations are acquired in a stepwise fashi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c6e005ddc1ab74b136a96ebfc72330
http://europepmc.org/articles/PMC7677169
http://europepmc.org/articles/PMC7677169
Autor:
Aik Ooi, Jacqueline Marin, Saurabh Gulati, Daniel Mendoza, Manimozhi Manivannan, Saurabh Parikh, Katherine Thompson, Benjamin Schroeder, Shu Wang
Publikováno v:
Cancer Research. 81:246-246
Single cell multiomics assays targeting RNA and Protein from the same cell provide a high-resolution view of the heterogeneity of the sample. However both analytes target the phenotype of the cells and unambiguous inference that a cellular phenotype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0dff7c510098df5175858eeba5ac1d2
https://doi.org/10.1158/1538-7445.am2021-246
https://doi.org/10.1158/1538-7445.am2021-246
Autor:
Shu Wang, Pedro Mendez, Nigel Beard, Anders Ståhlberg, David Ruff, Göran Landberg, Saurabh Gulati, Manimozhi Manivannan, Mikael Kubista, Aik Ooi, Dalia Dhingra, Jens Björkman
Publikováno v:
Cancer Research. 80:2506-2506
The TCGA, ICGC and other research consortiums has shown that an integral, multi-omic analysis of tumors is necessary in order to understand a more complete picture of the signaling pathways involved in development, evolution, prognosis and treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dff835c3c8d8983c1e737cc691875ca
https://doi.org/10.1158/1538-7445.am2020-2506
https://doi.org/10.1158/1538-7445.am2020-2506
Autor:
Ben Liu, Anup Parikh, Dong Kim, Saurabh Parikh, Manimozhi Manivannan, Saurabh Gulati, Shu Wang, Sombeet Sahu, Kaustubh Gokhale
Publikováno v:
Cancer Research. 80:865-865
Background: While scRNA-seq helps in obtaining high-resolution views of single-cell heterogeneity through characterization of the functional state of cells, our understanding of the cellular properties and population architectures of heterogeneous ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29196d5413b7c3d803bdef85aeb50606
https://doi.org/10.1158/1538-7445.am2020-865
https://doi.org/10.1158/1538-7445.am2020-865
Autor:
Dong Kim, Nigel Beard, Sombeet Sahu, Saurabh Gulati, Saurabh Parikh, Nianzhen Li, Manimozhi Manivannan, Shu Wang
Publikováno v:
Cancer Research. 80:2109-2109
Background: To realize the promise of precision medicine for cancer, assessing genetic variation present in rare cells and understanding the role that these cells play in the evolution of tumor progression is essential. High throughput single cell DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9569b0d1a417996d5f4406238ef12778
https://doi.org/10.1158/1538-7445.am2020-2109
https://doi.org/10.1158/1538-7445.am2020-2109
Autor:
Saurabh Parikh, Saurabh Gulati, Nigel Beard, Kim Dong, Shu Wang, Sombeet Sahu, Anup Parikh, Manimozhi Manivannan
Publikováno v:
Cancer Research. 80:861-861
Background: It is now possible to interrogate thousands of cells in a single experiment for studying genetic variability with the advancements in single-cell sequencing technologies. Single-cell DNA platforms like Tapestri is still susceptible to err
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77abc031389699afd13b3685f3eaad69
https://doi.org/10.1158/1538-7445.am2020-861
https://doi.org/10.1158/1538-7445.am2020-861
Autor:
Shu Wang, Kaustubh Gokhale, Keith Jones, David Ruff, Manimozhi Manivannan, Dennis J. Eastburn, Dalia Dhingra, Charlie Silver, Nianzhen Li, Pedro Mendez, Adam Sciambi
Publikováno v:
Cancer Research. 79:3540-3540
Recent advancements in single cell analysis technologies are now able to provide insights into genomic DNA content, RNA expression and protein surface markers. In bulk assays, the effect of genetic variation on gene expression would be masked by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44ae841fc71131c656567cc4ce954429
https://doi.org/10.1158/1538-7445.am2019-3540
https://doi.org/10.1158/1538-7445.am2019-3540
Autor:
Robert Durruthy-Durruthy, Adam Sciambi, Dong Kim, Shu Wang, Jordan Wilheim, Keith Jones, Manimozhi Manivannan, Niranjan Vissa, Sombeet Sahu, Anup Parikh, Nianzhen Li
Publikováno v:
Cancer Research. 79:1663-1663
Current bulk sequencing paradigms are inadequate to characterize complicated biological systems where somatic variation is buried in the landscape of populations. Single-cell DNA sequencing can simultaneously identify zygosity, rare alleles and deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7b59efb3c0a1c23f1224c4f1ca35077
https://doi.org/10.1158/1538-7445.am2019-1663
https://doi.org/10.1158/1538-7445.am2019-1663
Autor:
Habib Hamidi, Matthew C. Hiemenz, Susan Ewald, Karen L. Clyde, Timothy J. Triche, Paul D. Williams, Dejerianne Ostrow, Alan S. Wayne, Alexander R. Judkins, Raca Gordana, Tracy M. Busse, Efren Ballesteros-Villagrana, Jingwei Ni, David M. Parham, Chaitali Parikh, Jaclyn A. Biegel, Scott P. Myrand, Dinesh Cyanam, Jonathan D. Buckley, Nickolay A. Khazanov, Xiaowu Gai, Mark Tomilo, Deepa Bhojwani, Jon Sherlock, Armand Bankhead, Seth Sadis, Manimozhi Manivannan, Matthew J. Oberley, Janice K. Au-Young
Publikováno v:
Cancer Research. 78:B45-B45
Introduction: Recurrent somatic alterations associated with pediatric, childhood, and young adult cancers have not been as intensively studied as those associated with adult cancers. Consequently, whole-exome and transcriptome approaches are still be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::173d2da5a0d5168d8cc4c13d0d3171d0
https://doi.org/10.1158/1538-7445.pedca17-b45
https://doi.org/10.1158/1538-7445.pedca17-b45