Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Manikandan Periyasamy"'
Autor:
Manikandan Periyasamy, Hetal Patel, Chun-Fui Lai, Van T.M. Nguyen, Ekaterina Nevedomskaya, Alison Harrod, Roslin Russell, Judit Remenyi, Anna Maria Ochocka, Ross S. Thomas, Frances Fuller-Pace, Balázs Győrffy, Carlos Caldas, Naveenan Navaratnam, Jason S. Carroll, Wilbert Zwart, R. Charles Coombes, Luca Magnani, Laki Buluwela, Simak Ali
Publikováno v:
Cell Reports, Vol 13, Iss 1, Pp 108-121 (2015)
Estrogen receptor α (ERα) is the key transcriptional driver in a large proportion of breast cancers. We report that APOBEC3B (A3B) is required for regulation of gene expression by ER and acts by causing C-to-U deamination at ER binding regions. We
Externí odkaz:
https://doaj.org/article/0888c564b94245ac837fe1a7d55a9dc2
Autor:
Van T. M. Nguyen, Iros Barozzi, Monica Faronato, Ylenia Lombardo, Jennifer H. Steel, Naina Patel, Philippa Darbre, Leandro Castellano, Balázs Győrffy, Laura Woodley, Alba Rodriguez-Meira, Darren K. Patten, Valentina Vircillo, Manikandan Periyasamy, Simak Ali, Gianmaria Frige, Saverio Minucci, R. Charles Coombes, Luca Magnani
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/69915c68314f4c4da72a9fec0920fcd9
Autor:
Inês G Mollet, Dilipkumar Patel, Fatima S Govani, Adam Giess, Koralia Paschalaki, Manikandan Periyasamy, Elaine C Lidington, Justin C Mason, Michael D Jones, Laurence Game, Simak Ali, Claire L Shovlin
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0147990 (2016)
BACKGROUND:Spontaneous reports from patients able to report vascular sequelae in real time, and recognition that serum non transferrin bound iron may reach or exceed 10μmol/L in the blood stream after iron tablets or infusions, led us to hypothesize
Externí odkaz:
https://doaj.org/article/2124d7e947f44e82b62022015bd7087c
Autor:
Simak Ali, R. Charles Coombes, Anthony G. M. Barrett, Matthew J. Fuchter, Laki Buluwela, Eric O. Aboagye, Alison Harrod, Silvia Ottaviani, Richard Starkey, Marion Barbazanges, Sebastian H. B. Kroll, Brian W. Slafer, Alexander Bondke, Georgina P. Sava, Manikandan Periyasamy, Hetal Patel
In vitro kinase assays demonstrate selectivity of ICEC0942 for CDK7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3115379f20023b58b11b5bd3f114b3e9
https://doi.org/10.1158/1535-7163.22505256.v1
https://doi.org/10.1158/1535-7163.22505256.v1
Autor:
Simak Ali, R. Charles Coombes, Anthony G. M. Barrett, Matthew J. Fuchter, Laki Buluwela, Eric O. Aboagye, Alison Harrod, Silvia Ottaviani, Richard Starkey, Marion Barbazanges, Sebastian H. B. Kroll, Brian W. Slafer, Alexander Bondke, Georgina P. Sava, Manikandan Periyasamy, Hetal Patel
Recent reports indicate that some cancer types are especially sensitive to transcription inhibition, suggesting that targeting the transcriptional machinery provides new approaches to cancer treatment. Cyclin-dependent kinase (CDK)7 is necessary for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7954b2e0f9b8731f18d462f3b2edad27
https://doi.org/10.1158/1535-7163.c.6537999.v1
https://doi.org/10.1158/1535-7163.c.6537999.v1
Autor:
Simak Ali, R. Charles Coombes, Anthony G. M. Barrett, Matthew J. Fuchter, Laki Buluwela, Eric O. Aboagye, Alison Harrod, Silvia Ottaviani, Richard Starkey, Marion Barbazanges, Sebastian H. B. Kroll, Brian W. Slafer, Alexander Bondke, Georgina P. Sava, Manikandan Periyasamy, Hetal Patel
Figure legends for supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e68a2e65994bf8e6171e2a36349138
https://doi.org/10.1158/1535-7163.22505235
https://doi.org/10.1158/1535-7163.22505235
Autor:
Simak Ali, R. Charles Coombes, Ian O. Ellis, Emad A. Rakha, Laki Buluwela, Sami Shousha, Frances Fuller-Pace, Louise J. Jones, Balázs Győrffy, Luca Magnani, Jennifer J. Gomm, Sally Smith, Judit Remenyi, Dena Jerjees, Claudia Busonero, Naina Patel, Jennifer H. Steel, Carolina Gemma, Alison Harrod, Manikandan Periyasamy, Chun-Fui Lai, Rezvan Abduljabbar, Hetal Patel
Supplementary Table 1. Multivariate Cox Regression Analysis for Time to Distant Metastasis (TTDM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de403ba18d48c3e7e197a85a45eed3a
https://doi.org/10.1158/1078-0432.22458171.v1
https://doi.org/10.1158/1078-0432.22458171.v1
Autor:
Simak Ali, R. Charles Coombes, Ian O. Ellis, Emad A. Rakha, Laki Buluwela, Sami Shousha, Frances Fuller-Pace, Louise J. Jones, Balázs Győrffy, Luca Magnani, Jennifer J. Gomm, Sally Smith, Judit Remenyi, Dena Jerjees, Claudia Busonero, Naina Patel, Jennifer H. Steel, Carolina Gemma, Alison Harrod, Manikandan Periyasamy, Chun-Fui Lai, Rezvan Abduljabbar, Hetal Patel
Supplementary Figure 1. Expression of CDK7, cyclin H and MAT1 is elevated in breast cancer. Supplementary Figure 2. Relationship between mRNA levels of CDK7, cyclin H and MAT1 in breast cancer. Supplementary Figure 3. Profiling of CDK7, Cyclin H and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022b0dc1d4bc3716a7cb72ef996390db
https://doi.org/10.1158/1078-0432.22458174.v1
https://doi.org/10.1158/1078-0432.22458174.v1
Autor:
Simak Ali, R. Charles Coombes, Ian O. Ellis, Emad A. Rakha, Laki Buluwela, Sami Shousha, Frances Fuller-Pace, Louise J. Jones, Balázs Győrffy, Luca Magnani, Jennifer J. Gomm, Sally Smith, Judit Remenyi, Dena Jerjees, Claudia Busonero, Naina Patel, Jennifer H. Steel, Carolina Gemma, Alison Harrod, Manikandan Periyasamy, Chun-Fui Lai, Rezvan Abduljabbar, Hetal Patel
Purpose: CDK-activating kinase (CAK) is required for the regulation of the cell cycle and is a trimeric complex consisting of cyclin-dependent kinase 7 (CDK7), Cyclin H, and the accessory protein, MAT1. CDK7 also plays a critical role in regulating t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa678e7db7bda605727ecce058e9bd1
https://doi.org/10.1158/1078-0432.c.6523854.v1
https://doi.org/10.1158/1078-0432.c.6523854.v1
Autor:
R. Charles Coombes, Anthony G.M. Barrett, Eric O. Aboagye, Dennis C. Liotta, James P. Snyder, Seshu K. Kanneganti, Robert S. Tolhurst, Manikandan Periyasamy, Matthew J. Fuchter, Alekasandra Siwicka, Jan Brackow, Hetal Patel, Bodo Scheiper, Ashutosh S. Jogalekar, Sebastian H.B. Kroll, Dean A. Heathcote, Simak Ali
Supplementary Tables 1-5 from The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82e06802fba012d1ace4e528f121b2b0
https://doi.org/10.1158/0008-5472.22378400.v1
https://doi.org/10.1158/0008-5472.22378400.v1