Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Manikandan Kadirvel"'
Autor:
Biljana Arsic, Jill Barber, Ana Cikos, Manikandan Kadirvel, Emilija Kostic, Andrew J. McBain, Jelena Milicevic, Angela Oates, Andrew Regan
Publikováno v:
Molecules, Vol 27, Iss 21, p 7280 (2022)
Although many antibiotics are active against Gram-positive bacteria, fewer also show activity against Gram-negative bacteria. Here, we present a combination of in silico (electron ion-interaction potential, molecular docking, ADMET), NMR, and microbi
Externí odkaz:
https://doaj.org/article/6e59cbb94b5942ef9cc0601635fdd2a8
Autor:
Rok Krašovec, Roman V. Belavkin, John A.D. Aston, Alastair Channon, Elizabeth Aston, Bharat M. Rash, Manikandan Kadirvel, Sarah Forbes, Christopher G. Knight
Publikováno v:
Microbial Cell, Vol 1, Iss 7, Pp 250-252 (2014)
We do not need to rehearse the grim story of the global rise of antibiotic resistant microbes. But what if it were possible to control the rate with which antibiotic resistance evolves by de novo mutation? It seems that some bacteria may already do e
Externí odkaz:
https://doaj.org/article/a2914fa396a4493e8794be5d25869947
Autor:
Mai A. Elhemely, Asma A. Belgath, Sherihan El-Sayed, Kepa K. Burusco, Manikandan Kadirvel, Annalisa Tirella, Katherine Finegan, Richard A. Bryce, Ian J. Stratford, Sally Freeman
Publikováno v:
Journal of Medicinal Chemistry. 65:4783-4797
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ff7960c4d8e54664eab5163e9be558
https://doi.org/10.1021/acs.jmedchem.1c01936
https://doi.org/10.1021/acs.jmedchem.1c01936
Autor:
Thomas J. Smith, Paula G. Chirila, L Jaques, Melissa M. Lacey, KL Parkin, Sarah Forbes, Manikandan Kadirvel, EL Henly, Karl Norris, K Rawson, Christopher J. Whiteoak, N Zoulias
Background Quorum sensing is an extracellular bacterial communication system used in the density-dependent regulation of gene expression and development of biofilms. Biofilm formation has been implicated in the establishment of catheter-associated ur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82529ba679d770e18013f92be345d892
https://shura.shu.ac.uk/28017/10/Forbes-ImpactLong-term(AM).pdf
https://shura.shu.ac.uk/28017/10/Forbes-ImpactLong-term(AM).pdf
Publikováno v:
Journal of Radioanalytical and Nuclear Chemistry
Kadirvel, M, Cardoso, D, Freeman, S & Brown, G 2018, ' Radiosynthesis and reactivity of N-[11C]methyl carbamoylimidazole ', Journal of Radioanalytical and Nuclear Chemistry, vol. 317, no. 2 . https://doi.org/10.1007/s10967-018-5948-4
Kadirvel, M, Cardoso, D, Freeman, S & Brown, G 2018, ' Radiosynthesis and reactivity of N-[11C]methyl carbamoylimidazole ', Journal of Radioanalytical and Nuclear Chemistry, vol. 317, no. 2 . https://doi.org/10.1007/s10967-018-5948-4
N-Methyl carbamoylimidazole is a safe and practical alternative to methyl isocyanate for carbamoylation reactions. We have developed a new chemical route for its synthesis from methyl iodide and applied this to the synthesis of N-[11C]methyl carbamoy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf58bff3c674767fe5e56cd74f88680
http://europepmc.org/articles/PMC6061098
http://europepmc.org/articles/PMC6061098
Autor:
Sally Freeman, Izzeddin Alsalahat, Manikandan Kadirvel, Ian J. Stratford, Soraya Alnabulsi, Buthaina Hussein, Richard A. Bryce, Elham Santina, Rachael N. Magwaza, Alex G. Baldwin, Ilaria Russo, Carl H. Schwalbe
Publikováno v:
Alnabulsi, S, Hussein, B, Santina, E, Alsalahat, I, Kadirvel, M, Magwaza, R N, Bryce, R A, Schwalbe, C H, Baldwin, A G, Russo, I, Stratford, I J & Freeman, S 2018, ' Evaluation of analogues of furan-amidines as inhibitors of NQO2 ', Bioorganic & medicinal chemistry letters . https://doi.org/10.1016/j.bmcl.2018.03.025
Inhibitors of the enzyme NQO2 (NRH: quinone oxidoreductase 2) are of potential use in cancer chemotherapy and malaria. We have previously reported that non-symmetrical furan amidines are potent inhibitors of NQO2 and here novel analogues are evaluate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1fefe3aeaedbb824fac418a62e2b723
https://doi.org/10.1016/j.bmcl.2018.03.025
https://doi.org/10.1016/j.bmcl.2018.03.025
Autor:
Sally Freeman, Richard A. Bryce, Rachael N. Magwaza, Ian J. Stratford, Balqees Ikhmais, Manikandan Kadirvel, Gavin Halbert, Buthaina Hussein
Publikováno v:
Freeman, S, Stratford, I, Kadirvel, M & Bryce, R 2019, ' Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2) ', European Journal of Medicinal Chemistry . https://doi.org/10.1016/j.ejmech.2019.111649
(NRH):quinone oxidoreductase 2 (NQO2) is associated with various processes involved in cancer initiation and progression probably via the production of ROS during quinone metabolism. Thus, there is a need to develop inhibitors of NQO2 that are active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd6ef829791385f3284d46add7c94a5
https://pubmed.ncbi.nlm.nih.gov/31514018
https://pubmed.ncbi.nlm.nih.gov/31514018
Autor:
Karen A. Nolan, Richard A. Bryce, Constantinos Demonacos, Ian J. Stratford, Sally Freeman, Buthaina Hussein, Amy L. Chadwick, Elena V. Bichenkova, Elham Santina, Ilaria Russo, Manikandan Kadirvel, Soraya Alnabulsi
Publikováno v:
Alnabulsi, S, Santina, E, Russo, I, Hussein, B, Kadirvel, M, Chadwick, A, Bichenkova, E, Bryce, R, Nolan, K, Demonacos, C, Stratford, I & Freeman, S 2016, ' Non-symmetrical furan-amidines as novel leads for the treatment of cancer and malaria ', European Journal of Medicinal Chemistry, vol. 111, pp. 33-45 . https://doi.org/10.1016/j.ejmech.2016.01.022
NRH:quinone oxidoreductase 2 enzyme (NQO2) is a potential therapeutic target in cancer and neurodegenerative diseases, with roles in either chemoprevention or chemotherapy. Here we report the design, synthesis and evaluation of non-symmetrical furan-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f400e810cef184cc2586a95fb363f62
https://doi.org/10.1016/j.ejmech.2016.01.022
https://doi.org/10.1016/j.ejmech.2016.01.022
Autor:
Gavin Brown, Nigel Westwood, Michael Green, Sue Siew Chen Chua, Jonathan Lowe, Adam McMahon, Manikandan Kadirvel
Publikováno v:
Green, M, Lowe, J, Kadirvel, M, Mcmahon, A, Westwood, N, Chua, S S C & Brown, G 2017, ' Radiosynthesis of no-carrier-added meta-[124I] iodobenzylguanidine for PET imaging of metastatic neuroblastoma ' Journal of Radioanalytical and Nuclear Chemistry, vol 311, no. 1 . DOI: 10.1007/s10967-016-5073-1
Green, M, Lowe, J, Kadirvel, M, Mcmahon, A, Westwood, N, Chua, S S C & Brown, G 2017, ' Radiosynthesis of no-carrier-added meta-[124I] iodobenzylguanidine for PET imaging of metastatic neuroblastoma ', Journal of Radioanalytical and Nuclear Chemistry, vol. 311, no. 1 . https://doi.org/10.1007/s10967-016-5073-1
Green, M, Lowe, J, Kadirvel, M, Mcmahon, A, Westwood, N, Chua, S S C & Brown, G 2017, ' Radiosynthesis of no-carrier-added meta-[124I] iodobenzylguanidine for PET imaging of metastatic neuroblastoma ', Journal of Radioanalytical and Nuclear Chemistry, vol. 311, no. 1 . https://doi.org/10.1007/s10967-016-5073-1
Meta-iodobenzylguanidine (mIBG) has been radiolabelled at the no-carrier-added level with [124I] for a proof of concept study to assess the diagnostic accuracy of [124I]mIBG PET/CT in detecting metastatic deposits in patients diagnosed with metastati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::898e77cf8ac80eff58c94a19259cf926
https://pure.manchester.ac.uk/ws/files/54096051/art_10.1007_s10967_016_5073_1.pdf
https://pure.manchester.ac.uk/ws/files/54096051/art_10.1007_s10967_016_5073_1.pdf
Autor:
Gavin Brown, Muhammad Babur, Alison Smigova, Christopher Cawthorne, Kaye J. Williams, Paul Birkket, Manikandan Kadirvel, Emily J. Rowling, Michael Fairclough, Adam McMahon, Sally Freeman
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:341-349
The diethyl ester of [(18)F]ML-10 is a small molecule apoptotic PET probe for cancer studies. Here we report a novel multi-step synthesis of the diethyl ester of ML-10 in excellent yields via fluorination using Xtal-Fluor-E. In addition, a one-pot ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb2d029480028deca027fa40e2445bd3
https://doi.org/10.1016/j.bmc.2013.11.019
https://doi.org/10.1016/j.bmc.2013.11.019