Výsledky vyhledávání - "Manika Awasthi"

CoMFA and CoMSIA-based designing of resveratrol derivatives as amyloid-beta aggregation inhibitors against Alzheimer's disease

Autor: Upendra N. Dwivedi, Veda P. Pandey, Swati Singh, Manika Awasthi

Publikováno v: Medicinal Chemistry Research. 27:1167-1185

Resveratrol (3,4′,5-trihydroxystilbene) has been reported to promote degradation of intracellular amyloid-beta (Aβ) aggregates in Alzheimer’s disease (AD). In the present paper, we report comparative molecular field analysis (CoMFA)-based and co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3e4f48e4e6857f0be1cdf10f6dd3cc3
https://doi.org/10.1007/s00044-018-2138-4

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Modulation of interaction of mutant TP53 and wild type BRCA1 by alkaloids: a computational approach towards targeting protein-protein interaction as a futuristic therapeutic intervention strategy for breast cancer impediment

Autor: Sameeksha Tiwari, Veda P. Pandey, Swati Singh, Manika Awasthi, Upendra N. Dwivedi

Publikováno v: Journal of Biomolecular Structure and Dynamics. 36:3376-3387

Protein-protein interactions (PPI) are a new emerging class of novel therapeutic targets. In order to probe these interactions, computational tools provide a convenient and quick method towards the development of therapeutics. Keeping this in view th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d80a9ff017c8125d9f930c83dc5f0e2
https://doi.org/10.1080/07391102.2017.1388286

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Terpenoids as promising therapeutic molecules against Alzheimer’s disease: amyloid beta- and acetylcholinesterase-directed pharmacokinetic and molecular docking analyses

Autor: Veda P. Pandey, Arun K. Upadhyay, Upendra N. Dwivedi, Swati Singh, Manika Awasthi

Publikováno v: Molecular Simulation. 44:1-11

Alzheimer’s disease (AD) is a progressive neurological disorder of brain encompassing deterioration of cognitive functions and behavioural changes eventually leading to cell death and dementia. Sev...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b54e4b2daed2d6188a1e71d2e4f45e5
https://doi.org/10.1080/08927022.2017.1334880

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Plant derived anti-cancerous secondary metabolites as multipronged inhibitor of COX, Topo, and aromatase: molecular modeling and dynamics simulation analyses

Autor: Veda P. Pandey, Upendra N. Dwivedi, Manika Awasthi, Swati Singh

Publikováno v: Journal of Biomolecular Structure and Dynamics. 35:3082-3097

In the present study, 300 plant derived secondary metabolites (100 each of alkaloid, flavonoid, and terpenoid), have been screened for their anti-cancerous activity through inhibition of selected key enzymatic targets, namely cyclooxygenases (COXs),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0aa6d0aceeec84860e722a7e9642ebb
https://doi.org/10.1080/07391102.2016.1241720

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Citrus Functional Genomics and Molecular Modeling in Relation to Citrus sinensis (Sweet Orange) Infection with Xylella fastidiosa (Citrus Variegated Chlorosis)

Autor: Swati Singh, Manika Awasthi, Veda P. Pandey, Sameeksha Tiwari, Pragya Prasanna, Upendra N. Dwivedi

Publikováno v: OMICS: A Journal of Integrative Biology. 20:485-490

Citrus are among the economically most important fruit tree crops in the world. Citrus variegated chlorosis (CVC), caused by Xylella fastidiosa infection, is a serious disease limiting citrus production at a global scale. With availability of citrus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c035f44c9ba0394bea17d7377d66c4
https://doi.org/10.1089/omi.2016.0062

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Natural Products as Anticancerous Therapeutic Molecules with Special Reference to Enzymatic Targets Topoisomerase, COX, LOX and Aromatase

Autor: Manika Awasthi, Veda P. Pandey, Upendra N. Dwivedi, Swati Singh

Publikováno v: Current Protein & Peptide Science. 19

Cancer, characterized by uncontrolled growth and proliferation of cells, is affecting millions of people every year and estimated as the second leading cause of death. Its successful treatment yet remains a challenge due to the lack of selectivity, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c34709e073fe668f55cb67b00057db
https://doi.org/10.2174/1389203718666170106102223

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DNA topoisomerase-directed anticancerous alkaloids: ADMET-based screening, molecular docking, and dynamics simulation

Autor: Veda P. Pandey, Manika Awasthi, Tamal Das, Upendra N. Dwivedi, Swati Singh, Brijesh Pandey

Publikováno v: Biotechnology and Applied Biochemistry. 63:125-137

Topoisomerases (Topo I and II) have been looked as crucial targets against various types of cancers. In the present paper, 100 anticancerous alkaloids were subjected to in silico absorption, distribution, metabolism, excretion, and toxicity (ADMET) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e52110db54ca4218ce581a5dacb6b0ca
https://doi.org/10.1002/bab.1346

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