Výsledky vyhledávání - "Manik L. Debnath"

Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue

Autor: Stephen N. Gomperts, William E. Klunk, Milos D. Ikonomovic, Marta Marquié, Bradford C. Dickerson, Isabel Costantino, Lisa G. Rycyna, Bradley T. Hyman, Keith A. Johnson, Teresa Gomez-Isla, John H. Growdon, Chester A. Mathis, Charles R. Vanderburg, Elizabeth Bien, Manik L. Debnath, Marc D. Normandin, Neil Vasdev, Matthew P. Frosch

Publikováno v: Annals of Neurology. 78:787-800

Objective To examine region- and substrate-specific autoradiographic and in vitro binding patterns of positron emission tomography tracer [F-18]-AV-1451 (previously known as T807), tailored to allow in vivo detection of paired helical filament-tau–

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b1acdbb81a7e876322b1d728381b57c
https://doi.org/10.1002/ana.24517

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Design, synthesis and structure–activity relationship of rhenium 2-arylbenzothiazoles as β-amyloid plaque binding agents

Autor: N.S. Mason, Jinhe Pan, Kuo-Shyan Lin, William E. Klunk, Chester A. Mathis, Manik L. Debnath

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 23:1720-1726

To continue our efforts toward the development of 99mTc PiB analogs, we have synthesized twenty-four neutral and lipophilic Re (as a surrogate of 99mTc) 2-arylbenzothiazoles, and explored their structure-activity relationship for binding to Aβ1–40

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56636c65b2a0ad92785d2cd41293284c
https://doi.org/10.1016/j.bmcl.2013.01.068

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Early AD pathology in a [C-11]PiB-negative case: a PiB-amyloid imaging, biochemical, and immunohistochemical study

Autor: Ronald L. Hamilton, Chester A. Mathis, Julie C. Price, William R. Paljug, William E. Klunk, Steven T. DeKosky, Oscar L. Lopez, Milos D. Ikonomovic, Katsuyoshi Mizukami, Anne D. Cohen, Manik L. Debnath, Eric E. Abrahamson

Publikováno v: Acta Neuropathologica. 123:433-447

Amyloid-β (Aβ) deposits are detectable in the brain in vivo using positron emission tomography (PET) and [C-11]-labeled Pittsburgh Compound B ([C-11]PiB); however, the sensitivity of this technique is not well understood. In this study, we examined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52eb96d4e87d4fe0148713b5cd25c970
https://doi.org/10.1007/s00401-012-0943-2

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Anti-Amyloid Effects of Small Molecule Aβ-Binding Agents in PS1/APP Mice

Autor: Annie Cohen, Milos D. Ikonomovic, L Shao, William E. Klunk, N.S. Mason, Radosveta Koldamova, W. R. Paljug, Iliya Lefterov, Steven T. DeKosky, Chester A. Mathis, Manik L. Debnath, Eric E. Abrahamson

Publikováno v: Letters in Drug Design & Discovery. 6:437-444

AIMS: One promising approach for treatment of Alzheimer's disease (AD) is use of anti-amyloid therapies, based on the hypothesis that increases in amyloid-beta (Aβ) deposits in brain are a major cause of AD. Several groups have focused on Aβ immuno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e44978d9083954b58ea7c351d90c4f5a
https://doi.org/10.2174/157018009789057526

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Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue

Autor: Marta, Marquié, Marc D, Normandin, Charles R, Vanderburg, Isabel M, Costantino, Elizabeth A, Bien, Lisa G, Rycyna, William E, Klunk, Chester A, Mathis, Milos D, Ikonomovic, Manik L, Debnath, Neil, Vasdev, Bradford C, Dickerson, Stephen N, Gomperts, John H, Growdon, Keith A, Johnson, Matthew P, Frosch, Bradley T, Hyman, Teresa, Gómez-Isla

Publikováno v: Annals of neurology. 78(5)

To examine region- and substrate-specific autoradiographic and in vitro binding patterns of positron emission tomography tracer [F-18]-AV-1451 (previously known as T807), tailored to allow in vivo detection of paired helical filament-tau-containing l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a74763065fdbf814c9269a47e033eab1
https://pubmed.ncbi.nlm.nih.gov/26344059

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Binding of the Positron Emission Tomography Tracer Pittsburgh Compound-B Reflects the Amount of Amyloid-β in Alzheimer's Disease Brain But Not in Transgenic Mouse Brain

Autor: Radosveta Koldamova, Daniel P. Holt, Chester A. Mathis, William E. Klunk, Iliya Lefterov, Brian J. Lopresti, Steven T. DeKosky, Li Shao, Eric E. Abrahamson, Guo Feng Huang, Milos D. Ikonomovic, Julie C. Price, Manik L. Debnath

Publikováno v: The Journal of Neuroscience. 25:10598-10606

During the development ofin vivoamyloid imaging agents, an effort was made to use micro-positron emission tomography (PET) imaging in the presenilin-1 (PS1)/amyloid precursor protein (APP) transgenic mouse model of CNS amyloid deposition to screen ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596a986318af6ae8308cd79a3fe53457
https://doi.org/10.1523/jneurosci.2990-05.2005

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An Aβ Sequestration Approach Using Non-Antibody Aβ Binding Agents

Autor: Manik L. Debnath, Chester A. Mathis, Audrey J. Gray, John LaFrancois, Paul S. Aisen, Karen Duff, Yasuji Matsuoka, William E. Klunk, Amanda G. Becker, Li Shao

Publikováno v: Current Alzheimer Research. 2:265-268

Amyloid beta (Abeta) has been considered as a primary cause of Alzheimers disease (AD), and Abeta lowering approaches have been tested. Active immunization against Abeta is one of several promising Abeta-lowering approaches. Two mechanisms have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c160d8ff25c8f3fdb67890a1ff9b1c60
https://doi.org/10.2174/1567205053585774

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