Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection

Autor: Khan, K., Karim, F., Ganga, Y., Bernstein, M., Jule, Z., Reedoy, K., Cele, S., Lustig, G., Amoako, D., Wolter, N., Samsunder, N., Sivro, A., San, J., Giandhari, J., Tegally, H., Pillay, S., Naidoo, Y., Mazibuko, M., Miya, Y., Ngcobo, N., Manickchund, N., Magula, N., Karim, Q., von Gottberg, A., Karim, S., Hanekom, W., Gosnell, B., Team, C., Lessells, R., de Oliveira, T., Moosa, M., Sigal, A.

Publikováno v: Nature Communications

SARS-CoV-2 Omicron (B.1.1.529) BA.4 and BA.5 sub-lineages, first detected in South Africa, have changes relative to Omicron BA.1 including substitutions in the spike receptor binding domain. Here we isolated live BA.4 and BA.5 viruses and measured BA

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https://doi.org/10.1038/s41467-022-32396-9

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Omicron infection of vaccinated individuals enhances neutralizing immunity against the Delta variant.

Autor: Khan K; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Karim F; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Cele S; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., San JE; KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa., Lustig G; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa., Tegally H; KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa.; Centre for Epidemic Response and Innovation, School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa., Rosenberg Y; Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel., Bernstein M; Africa Health Research Institute, Durban, South Africa., Ganga Y; Africa Health Research Institute, Durban, South Africa., Jule Z; Africa Health Research Institute, Durban, South Africa., Reedoy K; Africa Health Research Institute, Durban, South Africa., Ngcobo N; Africa Health Research Institute, Durban, South Africa., Mazibuko M; Africa Health Research Institute, Durban, South Africa., Mthabela N; Africa Health Research Institute, Durban, South Africa., Mhlane Z; Africa Health Research Institute, Durban, South Africa., Mbatha N; Africa Health Research Institute, Durban, South Africa., Miya Y; Africa Health Research Institute, Durban, South Africa., Giandhari J; KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa., Ramphal Y; KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa., Naidoo T; Africa Health Research Institute, Durban, South Africa., Manickchund N; Department of Infectious Diseases, Nelson R. Mandela School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa., Magula N; Department of Internal Medicine, Nelson R. Mandela School of Medicine. University of Kwa-Zulu Natal., Abdool Karim SS; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, United States., Gray G; South African Medical Research Council, Cape Town, South Africa., Hanekom W; Africa Health Research Institute, Durban, South Africa.; Division of Infection and Immunity, University College London, London, UK., von Gottberg A; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; SAMRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Milo R; Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel., Gosnell BI; Department of Infectious Diseases, Nelson R. Mandela School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa., Lessells RJ; KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa.; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa., Moore PL; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; SAMRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa., de Oliveira T; KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa.; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.; Centre for Epidemic Response and Innovation, School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa.; Department of Global Health, University of Washington, Seattle, USA., Moosa MS; Department of Infectious Diseases, Nelson R. Mandela School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa., Sigal A; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.; Max Planck Institute for Infection Biology, Berlin, Germany.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2022 Jan 28. Date of Electronic Publication: 2022 Jan 28.