Výsledky vyhledávání - "Manickavasagam Sundaram"

Functional and Molecular Characterization of Nucleobase Transport by Recombinant Human and Rat Equilibrative Nucleoside Transporters 1 and 2

Autor: Sylvia Y.M. Yao, Mark F. Vickers, Manickavasagam Sundaram, Amy M. L. Ng, James D. Young, Carol E. Cass, Stephen A. Baldwin

Publikováno v: Journal of Biological Chemistry. 277:24938-24948

The human (h) and rat (r) equilibrative (Na(+)-independent) nucleoside transporters (ENTs) hENT1, rENT1, hENT2, and rENT2 belong to a family of integral membrane proteins with 11 transmembrane domains (TMs) and are distinguished functionally by diffe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b6547ae8e0c3088d30cc06fec5efd372
https://doi.org/10.1074/jbc.m200966200

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Topology of a Human Equilibrative, Nitrobenzylthioinosine (NBMPR)-sensitive Nucleoside Transporter (hENT1) Implicated in the Cellular Uptake of Adenosine and Anti-cancer Drugs

Autor: Stephen A. Baldwin, Manickavasagam Sundaram, Jean C. Ingram, Carol E. Cass, Zoe A. Berry, Fatima Abidi, James D. Young, Sylvia Y.M. Yao

Publikováno v: Journal of Biological Chemistry. 276:45270-45275

The human equilibrative nucleoside transporter hENT1, the first identified member of the ENT family of integral membrane proteins, is the primary mechanism for the cellular uptake of physiologic nucleosides, including adenosine, and many anti-cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea921d64b1100c1b15a33f147eb44c79
https://doi.org/10.1074/jbc.m107169200

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Equilibrative Nucleoside Transporters: Mapping Regions of Interaction for the Substrate Analogue Nitrobenzylthioinosine (NBMPR) Using Rat Chimeric Proteins

Autor: Stephen A. Baldwin, Carol E. Cass, Sylvia Y.M. Yao, Manickavasagam Sundaram, Amy M. L. Ng, James D. Young

Publikováno v: Biochemistry. 40:8146-8151

The rat equilibrative nucleoside transporters rENT1 and rENT2 belong to a family of integral membrane proteins with 11 potential transmembrane segments (TMs) and are distinguished functionally by differences in sensitivity to inhibition by nitrobenzy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660fd574e43c4cd9ccfab11f1148946f
https://doi.org/10.1021/bi0101805

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Identification of Cys140 in helix 4 as an exofacial cysteine residue within the substrate-translocation channel of rat equilibrative nitrobenzylthioinosine (NBMPR)-insensitive nucleoside transporter rENT2

Autor: Sylvia Y. M. YAO, Manickavasagam SUNDARAM, Eugene G. CHOMEY, Carol E. CASS, Stephen A. BALDWIN, James D. YOUNG

Publikováno v: Biochemical Journal. 353:387-393

The human and rat equilibrative nucleoside transporter proteins hENT1, rENT1, hENT2 and rENT2 belong to a family of integral membrane proteins with 11 potential transmembrane segments (TMs), and are distinguished functionally by differences in transp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e59312324b65e78c5f36a49b67c34045
https://doi.org/10.1042/bj3530387

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Functional production and reconstitution of the human equilibrative nucleoside transporter (hENT1) in Saccharomyces cerevisiae

Autor: James D. Young, Rajam S. Mani, Manickavasagam Sundaram, Carol E. Cass, Stephen A. Baldwin, Mark F. Vickers, Douglas L. Hogue

Publikováno v: Biochemical Journal. 339:21-32

We have produced recombinant human equilibrative nucleoside transporter (hENT1) in the yeast Saccharomyces cerevisiae and have compared the binding of inhibitors of equilibrative nucleoside transport with the wild-type transporter and a N-glycosylati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fae01a0bd7f0e5d822bd59df294c49ae
https://doi.org/10.1042/bj3390021

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Cloning of a human nucleoside transporter implicated in the Cellular uptake of adenosine and chemotherapeutic drugs

Autor: Nick Beaumont, Christine E. Boumah, Manickavasagam Sundaram, Carol E. Cass, Sylvia Y.M. Yao, Imogen Coe, Francis Y. P. Kwong, Anthony Davies, Mark Griffiths, Stephen A. Baldwin, James D. Young

Publikováno v: Nature Medicine. 3:89-93

In most mammalian cells nucleoside uptake occurs primarily via broad-specificity, es (e, equilibrative; 5, sensitive to NBMPR inhibition) transporters that are potently inhibited by nitrobenzylthioinosine (NBMPR). These transporters are essential for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d7e2cbbc2f6fcd0755ffbfa1140e257
https://doi.org/10.1038/nm0197-89

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Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation

Autor: Sylvia Y M, Yao, Amy M L, Ng, Mark F, Vickers, Manickavasagam, Sundaram, Carol E, Cass, Stephen A, Baldwin, James D, Young

Publikováno v: The Journal of biological chemistry. 277(28)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1068cfdb9fdf9db21a9fe68975118b9e
https://pubmed.ncbi.nlm.nih.gov/12006583

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Transport of antiviral 3'-deoxy-nucleoside drugs by recombinant human and rat equilibrative, nitrobenzylthioinosine (NBMPR)-insensitive (ENT2) nucleoside transporter proteins produced in Xenopus oocytes

Autor: Manickavasagam Sundaram, Carol E. Cass, James D. Young, Sylvia Y.M. Yao, Amy M. L. Ng, Stephen A. Baldwin

Publikováno v: Molecular membrane biology. 18(2)

In the present study, one has determined the relative role of plasma membrane equilibrative (Na+-independent) ENT nucleoside transport proteins (particularly ENT2) in the uptake of antiviral nucleoside analogues for comparison with the previously rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b38cbc07f5bdb083c9acbd5dd700982
https://pubmed.ncbi.nlm.nih.gov/11463208

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Chimeric constructs between human and rat equilibrative nucleoside transporters (hENT1 and rENT1) reveal hENT1 structural domains interacting with coronary vasoactive drugs

Autor: James D. Young, Mark Griffiths, Amy M. L. Ng, Sylvia Y.M. Yao, Stephen A. Baldwin, Carol E. Cass, Manickavasagam Sundaram

Publikováno v: The Journal of biological chemistry. 273(34)

We have recently isolated cDNAs from human placenta and rat jejunum encoding the prototypic human and rat equilibrative nitrobenzylthioinosine (NBMPR)-sensitive nucleoside transporters hENT1 and rENT1. The two proteins (456 and 457 residues, Mr 50,00

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ff9d9f4cc0ba3102654e584c803b46
https://pubmed.ncbi.nlm.nih.gov/9705281

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The transfer of retinol from serum retinol-binding protein to cellular retinol-binding protein is mediated by a membrane receptor

Autor: Manickavasagam Sundaram, Monica M. DeSousa, John B. C. Findlay, Asipu Sivaprasadarao

Publikováno v: The Journal of biological chemistry. 273(6)

The hypothesis that the cellular uptake of retinol involves the specific interaction of a plasma membrane receptor with serum retinol-binding protein (RBP) at the extracellular surface followed by ligand transfer to cytoplasmic cellular retinol-bindi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2ac7a11e490fe4efd6d1bee30e78bb
https://pubmed.ncbi.nlm.nih.gov/9452451

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